Effect of Ramosetron on Bowel Motility After Gynecological Surgery

Last updated: January 11, 2017
Sponsor: Kyunghee University Medical Center
Overall Status: Trial Status Unknown

Phase

4

Condition

Colic

Vomiting

Lactose Intolerance

Treatment

N/A

Clinical Study ID

NCT02849483
KHUH 2016-05-201
  • Ages 20-70
  • Female

Study Summary

Ramosetron is effective in preventing postoperative nausea and vomiting. Several studies reported that ramosetron is also effective treatment of irritable bowel syndrome. The investigators examine the effect of ramosetron on postoperative bowel motility.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 20-70 yrs of age

  • ASA(American Society of Anesthesiologists) physical status class I or II

  • Scheduled for gynecological laparoscopic surgery

Exclusion

Exclusion Criteria:

  • Allergic to study drugs

  • Antiemetics or steroids use within 24 hrs prior to surgery

  • Dependence upon opioids

  • Insulin dependent Diabetes Mellitus

  • Cardiovascular or pulmonary disease

  • Renal or hepatic insufficiency

  • BMI>=35kg/m2

  • History of motion sickness or PONV

  • Cigarette smoker

  • Conversion to open laparotomy from laparoscopic surgery

  • Pregnants

Study Design

Total Participants: 88
Study Start date:
July 01, 2016
Estimated Completion Date:
July 31, 2017

Study Description

Ramosetron, a new potent and long-acting selective 5-HT3(5-hydroxytryptamine3) receptor anatagonist, is effective for preventing postoperative nausea and vomiting. Also several studies reported that ramosetron is effective treatment of diarrhea-predominant irritable bowel syndrome because it inhibits the accelerated colonic transit, abnormal colonic water transport, defecation abnormality, and the lowered colonic perceptual threshold by corticotrophin-releasing hormone, There is no study about the effect of ramosetron used for preventing postoperative nausea and vomiting on postoperative bowel motility. In this study, the investigators examine the effect of ramosetron on postoperative bowel motility.

Connect with a study center

  • Kyung Hee University Hospital

    Seoul, 02447
    Korea, Republic of

    Active - Recruiting

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