Metastatic Tumor Research and Outcomes Network

Last updated: February 24, 2026
Sponsor: AO Innovation Translation Center
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Neoplasm Metastasis

Neoplasms

Treatment

N/A

Clinical Study ID

NCT02830451
MTRON
  • Ages > 18
  • All Genders

Study Summary

The registry aims to collect patient information such as patient demographics, co-morbidities, clinical, diagnostic, and therapeutic data, as well as information on adverse events and HRQOL outcomes specific for patients with metastatic spine tumor(s).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient 18 or older.

  • Patient diagnosed with a metastatic tumor of the spine

  • Informed consent obtained, i.e.:

  • Ability to understand the content of the patient information/ICF

  • Willingness and ability to participate in the registry according to theRegistry Plan

  • Signed and dated EC/IRB approved written informed consent (if consent isrequired by the EC/ IRB at the registry site)

Exclusion

Exclusion Criteria:

• Patient diagnosed with a primary tumor of the spine.

Study Design

Total Participants: 960
Study Start date:
November 15, 2017
Estimated Completion Date:
August 15, 2026

Study Description

To prospectively determine the prognostic variables (clinical, diagnostic, and therapeutic) within patients diagnosed with metastatic spine tumor(s) that are associated with:

  • patient reported outcomes (HRQOL)

  • morbidity data

  • local tumor control

  • survival

Outcome measures:

Variables which will be collected in the registry that are applicable to patients with metastatic spine tumor include:

  • • Patient details

  • Details of previous treatment

  • Diagnosis

  • Symptoms

  • Treatment details for the index target

  • Imaging information

The following outcome measures will be collected:

  • Patient reported outcomes:

    • Euroqol EQ-5D-3L

    • Euroqol EQ-5D VAS - Quality of Life

    • Neck Pain Numeric Rating Scale (NRS)

    • Arm Pain NRS

    • Back Pain NRS

    • Leg Pain NRS

    • SOSGOQ

    • Patient assessment

  • Ambulation

  • Pain medication

  • Nutritional Status Tool (PG-SGA©)

  • Morbidity data

  • Local disease recurrence data

  • Overall survival data

Connect with a study center

  • Monash University Melbourne

    Clayton, Victoria 3168
    Australia

    Site Not Available

  • Monash University Melbourne

    Clayton 2171400, Victoria 2145234 3168
    Australia

    Site Not Available

  • Vancouver General Hospital and the University of British Columbia

    Vancouver, British Columbia V5Z 1M9
    Canada

    Site Not Available

  • Vancouver General Hospital and the University of British Columbia

    Vancouver 6173331, British Columbia 5909050 V5Z 1M9
    Canada

    Site Not Available

  • Winnipeg Spine Program University of Manitoba Department of Surgery

    Winnipeg, Manitoba R3A 1R9
    Canada

    Site Not Available

  • Winnipeg Spine Program University of Manitoba Department of Surgery

    Winnipeg 6183235, Manitoba 6065171 R3A 1R9
    Canada

    Site Not Available

  • Toronto Western Hospital Department of Neurosurgery Division of Surgery

    Toronto, Ontario 4W449
    Canada

    Active - Recruiting

  • University of Toronto Odette Cancer Centre - T2 158 Sunnybrook Health Sciences Ccenter

    Toronto, Ontario M4N 3M5
    Canada

    Site Not Available

  • Toronto Western Hospital Department of Neurosurgery Division of Surgery

    Toronto 6167865, Ontario 6093943 4W449
    Canada

    Site Not Available

  • University of Toronto Odette Cancer Centre - T2 158 Sunnybrook Health Sciences Ccenter

    Toronto 6167865, Ontario 6093943 M4N 3M5
    Canada

    Site Not Available

  • McGill University Health Centre

    Montréal, Quebec H3G 1A4
    Canada

    Site Not Available

  • McGill University Health Centre

    Montreal 6077243, Quebec 6115047 H3G 1A4
    Canada

    Site Not Available

  • Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden

    Dresden, Sachsen 01307
    Germany

    Site Not Available

  • Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden

    Dresden 2935022, Saxony 2842566 01307
    Germany

    Site Not Available

  • National Center for Spinal Disorders and Buda Health Center

    Budapest, 1126
    Hungary

    Site Not Available

  • National Center for Spinal Disorders and Buda Health Center

    Budapest 3054643, 1126
    Hungary

    Site Not Available

  • Instituto Ortopedico Rizzoli Department of Oncologic and Degenerative Spine Surgery

    Bologna, Emilia-Romagna 40136
    Italy

    Site Not Available

  • Instituto Ortopedico Rizzoli Department of Oncologic and Degenerative Spine Surgery

    Bologna 3181928, Emilia-Romagna 3177401 40136
    Italy

    Site Not Available

  • IRCCS Istituto Ortopedico Galeazzi Centro die Chirurgia Ortopedica Oncologica e Ricostr

    Milano, Lombardei 20161
    Italy

    Site Not Available

  • IRCCS Istituto Ortopedico Galeazzi Centro die Chirurgia Ortopedica Oncologica e Ricostr

    Milan 3173435, Lombardy 3174618 20161
    Italy

    Site Not Available

  • Kanazawa Medical University Hospital Department of Orthopaedic Surgery

    Uchinada, Ishikawa 920-0293
    Japan

    Site Not Available

  • Kanazawa Medical University Hospital Department of Orthopaedic Surgery

    Uchinoda, Ishikawa-ken 1861387 920-0293
    Japan

    Site Not Available

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3508
    Netherlands

    Site Not Available

  • Universitair Medisch Centrum Utrecht

    Utrecht 2745912, 3508
    Netherlands

    Site Not Available

  • National University of Singapore Department of Orthopaedic Surgery

    Singapore, 119288
    Singapore

    Site Not Available

  • National University of Singapore Department of Orthopaedic Surgery

    Singapore 1880252, 119288
    Singapore

    Site Not Available

  • Universitätsspital Basel Wirbelsäulenzentrum

    Basel 2661604, Basel 4031
    Switzerland

    Site Not Available

  • Universitätsspital Basel Wirbelsäulenzentrum

    Basel, 4031
    Switzerland

    Site Not Available

  • Oxford University Hospital NHS Trust Spinal Services

    Oxford, Oxfordshire OX3 7HE
    United Kingdom

    Site Not Available

  • University of California The UCSF Spine Center Department of Neurological Surgery

    San Francisco, California 94143
    United States

    Site Not Available

  • University of California The UCSF Spine Center Department of Neurological Surgery

    San Francisco 5391959, California 5332921 94143
    United States

    Site Not Available

  • Rush University Medical Center University Neurosurgery

    Chicago, Illinois 60612
    United States

    Site Not Available

  • Rush University Medical Center University Neurosurgery

    Chicago 4887398, Illinois 4896861 60612
    United States

    Site Not Available

  • Johns Hopkins University Department of Neurosurgery / Spine Division

    Baltimore, Maryland 21205
    United States

    Site Not Available

  • Johns Hopkins University Department of Neurosurgery / Spine Division

    Baltimore 4347778, Maryland 4361885 21205
    United States

    Site Not Available

  • Harvard Medical School Department of Neurosurgery

    Boston, Massachusetts 02114
    United States

    Site Not Available

  • Harvard Medical School Department of Neurosurgery

    Boston 4930956, Massachusetts 6254926 02114
    United States

    Site Not Available

  • Mayo Clinic Department of Neurosurgery

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Mayo Clinic Department of Neurosurgery

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Site Not Available

  • Memorial Sloan-Kettering Cancer Center

    New York, New York 10065
    United States

    Site Not Available

  • University of Rochester School of Medicine and Dentistry Department of Orthopaedic Surgery and Neurosurgery

    Rochester, New York 14642
    United States

    Active - Recruiting

  • Westchester Medical Center Department of Neurosurgery

    Valhalla, New York 10595
    United States

    Site Not Available

  • Memorial Sloan-Kettering Cancer Center

    New York 5128581, New York 5128638 10065
    United States

    Site Not Available

  • University of Rochester School of Medicine and Dentistry Department of Orthopaedic Surgery and Neurosurgery

    Rochester 5134086, New York 5128638 14642
    United States

    Site Not Available

  • Westchester Medical Center Department of Neurosurgery

    Valhalla 5142090, New York 5128638 10595
    United States

    Site Not Available

  • Penn Presbyterian Medical Center Department of Neurosurgery

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Penn Presbyterian Medical Center Department of Neurosurgery

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Site Not Available

  • The Warren Alpert Medical School of Brown university Department of Neurosurgery

    Providence, Rhode Island 02903
    United States

    Site Not Available

  • The Warren Alpert Medical School of Brown university Department of Neurosurgery

    Providence 5224151, Rhode Island 5224323 02903
    United States

    Site Not Available

  • The University of Texas MD Anderson Cancer Center Department of Neurosurgery

    Houston, Texas 77030
    United States

    Site Not Available

  • The University of Texas MD Anderson Cancer Center Department of Neurosurgery

    Houston 4699066, Texas 4736286 77030
    United States

    Site Not Available

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