Role of Fcgamma Receptors in Immune Thrombocytopenia (ITP)

Last updated: February 19, 2024
Sponsor: Centre Hospitalier Universitaire Dijon
Overall Status: Active - Recruiting

Phase

N/A

Condition

White Cell Disorders

Immune (Idiopathic) Thrombocytopenic Purpura (Itp)

Thrombosis

Treatment

spleen sample

blood sample

Clinical Study ID

NCT02821572
BONNOTTE PARI 2013
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a peripheral destruction of platelets responsible for bleedings.

Monocytes/macrophages play a double role by phagocyting platelets recognized by autoantibodies and by maintaining the autoimmune response via their antigen-presenting cell functions.

Fcgamma receptors (FcγR), that are represented by activating receptors (FcγRI, FcγRIIa, FcγRIII) and an inhibiting one (FcγRIIb), are involved in the regulation of macrophages and have been reported to be dysregulated in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematous.

The aim of this study is to compare the expression of FcγR in patients with ITP on circulating monocytes and on splenic macrophages.

Eligibility Criteria

Inclusion

Inclusion Criteria: ITP group

  • Patients who have provided written consent
  • Patients over 18 years
  • Patients with national health insurance
  • Patients with ITP, defined as thrombocytopenia < 100 G/L, after exclusion ofinfection- or drug-related thrombocytopenia and malignant hemopathy. Control Group
  • Persons who have provided a written consent
  • Persons over 18 years
  • Persons with national health insurance
  • Persons without autoimmune disease

Exclusion

Exclusion Criteria:

  • Patients under guardianship
  • Pregnancy

Study Design

Total Participants: 70
Treatment Group(s): 2
Primary Treatment: spleen sample
Phase:
Study Start date:
October 02, 2014
Estimated Completion Date:
September 30, 2024

Connect with a study center

  • CHU Dijon Bourgogne

    Dijon, 21079
    France

    Active - Recruiting

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