A Study of Atezolizumab Compared With Docetaxel in Non-Small Cell Lung Cancer (NSCLC) After Failure With Platinum-Containing Chemotherapy

Inclusion Criteria:

• Histologically documented, locally advanced or metastatic NSCLC
• Representative formalin-fixed paraffin-embedded (FFPE) tumor specimens available or atleast 12 unstained, freshly cut serial sections with associated pathology report thatare evaluable for PD-L1 expression and epidermal growth factor receptor (EGFR)mutation status prior to enrollment, except for known sensitizing EGFR mutations inwhich case 10 unstained slides are required and there is no need for central testingof EGFR mutation status
• Disease progression during or following treatment with a prior platinum-containingregimen for locally advanced, unresectable, inoperable, or metastatic NSCLC, ordisease recurrence within 6 months of treatment with a platinum-based adjuvant and/orneoadjuvant regimen or combined modality with curative intent
• Measurable disease per RECIST v1.1
• Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• Life expectancy greater than or equal to (>/=) 12 weeks
• Adequate hematologic and end organ function
• Agreement to remain abstinent or use contraceptive methods among women of childbearingpotential or male partners of women of childbearing potential
• Recovery from all acute toxicities from previous therapy

Exclusion Criteria:

• Active or untreated central nervous system (CNS) metastases
• Spinal cord compression not definitively treated or not clinically stable
• Leptomeningeal disease
• Uncontrolled pleural or pericardial effusions or ascites requiring recurrent drainage
• Uncontrolled tumor-related pain
• Uncontrolled hypercalcemia
• Malignancies other than NSCLC within 5 years prior to randomization, except for thosecuratively treated with negligible risk of metastasis or death
• Pregnant or lactating women
• Significant cardiovascular, pulmonary, or autoimmune disease
• Severe infection or major surgery within 4 weeks, or antibiotic treatment within 2weeks prior to randomization
• Prior treatment with or hypersensitivity to study drug(s) or related compounds
• Inability to discontinue strong cytochrome P450 (CYP) 3A4 inhibitors
• Prior allogeneic bone marrow or solid organ transplant
• Known PD-L1-negative expression status
• Positive human immunodeficiency virus (HIV) or active hepatitis B or C
• Receipt of a live attenuated vaccine within 4 weeks prior to randomization
• Treatment with systemic immunomodulators within 4 weeks or five half-lives (whicheveris shorter) prior to randomization
• Treatment with systemic corticosteroids within 2 weeks prior to randomization