PRediction of Opioid-induced Respiratory Depression In Patients Monitored by capnoGraphY

Inclusion Criteria:

1. Patients receiving parenteral opioid therapy (for post-surgical or non-surgical) painon the hospital ward.

2. Adult age (≥18 year old in US and Europe; ≥20 years old in Japan; ≥21 years old inSingapore).

3. Patient is able and willing to give informed consent.

Exclusion Criteria:

1. Expected length of stay ≤ 24 hours.

2. Patient is receiving intrathecal opioids.

3. Post-surgical patients with American Society of Anesthesiologists physical status (ASAPS) V or higher.

4. Patients with the status of Do Not Resuscitate (DNR), hospice, or receiving end oflife therapy.

5. Ventilated or intubated patients.

6. Patient is unwilling or unable to comply fully with study procedures (includingnon-toleration of the capnography cannula) due to any disease condition which canraise doubt about compliance and influencing the study outcome.

7. Patient is a member of a vulnerable population, including legal incapacity or evidencethat a subject cannot understand the purpose and risks of the study, regardless ofauthorized representative support.

8. Patient is participating in another potentially confounding drug or device clinicalstudy.