The Effect of Remote Ischemic Preconditioning on Major Organ Function in Patients With Coronary Artery Disease Undergoing Orthopedic Surgery

Last updated: September 3, 2017
Sponsor: Seoul National University Hospital
Overall Status: Completed

Phase

N/A

Condition

Heart Disease

Thrombosis

Congestive Heart Failure

Treatment

N/A

Clinical Study ID

NCT02808936
1604-079-754
  • Ages > 20
  • All Genders

Study Summary

The investigators attempt to investigate the organ protective effect of remote ischemic conditioning in patients undergoing non-cardiac surgery with history of ischemic heart disease.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults patients who undergo orthopedic surgery with duration of longer than one hour

  • Patients with a history of ischemic heart disease (stable or unstable angina,myocardial infarction)

  • American Society of Anesthesiology (ASA) Physical Status Classification of 1, 2, or 3

Exclusion

Exclusion Criteria:

  • Peripheral vascular disease involving upper or lower extremity

  • Orthopedic surgery which uses the tourniquet

Study Design

Total Participants: 60
Study Start date:
June 01, 2016
Estimated Completion Date:
June 30, 2017

Study Description

When adult patients with ischemic heart disease undergo non-cardiac surgery, perioperative ischemic complication may occur. These morbidity results in poor clinical outcomes. The incidence of perioperative myocardial ischemic event has been reported to be up to 19.7%. Remote ischemic preconditioning (RIPC) is a concept that a brief ischemic reperfusion of upper or lower extremity can transfer protection to the other vital organs from sustained ischemic reperfusion injury. Although RIPC is extensively studied in high risk cardiovascular surgery, it has not been tested in a non-cardiac surgery patients with a history of ischemic heart disease. Major organ injury including heart, lung and kidney will be evaluated in this randomized controlled trial.

Connect with a study center

  • Seoul National University Hospital

    Seoul, 03080
    Korea, Republic of

    Site Not Available

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