Brain Plasticity of Autism in Response to Early Behavioral Intervention: A Multimodal MRI Study

Last updated: January 11, 2024
Sponsor: University of Electronic Science and Technology of China
Overall Status: Active - Recruiting

Phase

N/A

Condition

Autism

Autism Spectrum Disorder (Asd)

Treatment

Behavior modification and TEACCH

Behavior modification and sensory integration training

Behavior modification

Clinical Study ID

NCT02807766
UESTC-chenhuafulab-001
  • Ages 2-8
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Autism is a well-recognized neurodevelopmental disorder severely affecting the health of children. While the unclear neurobiological basis of autism and the lack of effective medication, the most commonly used approach for treatment is behavioral intervention. However, the pathophysiological mechanisms underlying the intervention therapy remains incompletely understood. The current project aims to explore the impacts of different early behavioral intervention methods on brain plasticity of autism using multimodal MRI technique and provide guidelines for the intervention and treatment of autism by evaluating the efficiency of these methods.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age range from 2 to 8 years old.
  • Clinical DSM-IV diagnosis of autism.

Exclusion

Exclusion Criteria:

  • Subjects with other neurodevelopmental diseases.
  • Subjects with contraindications to MRI.

Study Design

Total Participants: 150
Treatment Group(s): 4
Primary Treatment: Behavior modification and TEACCH
Phase:
Study Start date:
May 01, 2016
Estimated Completion Date:
December 31, 2024

Study Description

Autism is a well-recognized neurodevelopmental disorder severely affecting the health of children. While the unclear neurobiological basis of autism and the lack of effective medication, the most commonly used approach for treatment is behavioral intervention. However, the pathophysiological mechanisms underlying the intervention therapy remains incompletely understood. The current project aims to explore the impacts of different early behavioral intervention methods on brain plasticity of autism using multimodal MRI technique and provide guidelines for the intervention and treatment of autism by evaluating the efficiency of these methods. Investigators collect participants' brain imaging data, eye movement data, stool samples and clinical scale score before and after intervention. Investigators first investigate longitudinal effect of behavioral intervention on brain structure and function in children with autism. In addition, investigators provide new biological indexes upon multimodal large-scale brain connectomes to evaluate the curative effect of intervention. Finally, investigators propose a prediction model of intervention effect based on multimodal multivariate pattern analysis methods. Furthermore, investigators expect to map the state-of-the-art biomarkers on multi-modal networks to provide a new interpretation of pathophysiological mechanisms of autism.

Connect with a study center

  • Department of Children's and Adolescent Health, Public Health College of Harbin Medical University

    Harbin, Heilongjiang 150086
    China

    Active - Recruiting

  • Center for Information in BioMedicine, Key laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China

    Chengdu, Sichuan 610054
    China

    Active - Recruiting

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