Effectiveness of Bifidobacteria in Children Affected by Seasonal Allergic Rhinitis

Last updated: June 25, 2018
Sponsor: University of Campania "Luigi Vanvitelli"
Overall Status: Active - Recruiting

Phase

3

Condition

Allergy

Nasal Obstruction

Common Cold

Treatment

N/A

Clinical Study ID

NCT02807064
TRB01
  • Ages 4-17
  • All Genders

Study Summary

This study is aimed at assessing the efficacy of supplementation with a mixture of three bifidobacteria , on the allergic rhinitis..The rhinitis symptoms were assessed by validated score ( TSS ) , for children aged between 4 and 17 years with allergic rhinitis parietaria , mild , moderate or severe , than children not supplemented .

Secondary Objectives

  • The effectiveness of treatment by VAS :

  • Evaluation of the rescue medication consumption

  • Evaluation of quality of life ( using structured questionnaire )

  • Evaluation of the frequency and school performance ( using structured questionnaire )

  • Assessment of sleep quality and attention (through structured questionnaire )

  • Satisfaction rating and satisfaction of parents

  • Evaluation of asthma exacerbations in children susceptible

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Children of both sexes , aged from 4 to 17 years

  • History seasonal allergic rhinitis mild , moderate or severe , according to theguidelines defined AIR 2013 , documented by recurrent episodes in the previous yearand confirmed by skin prick test positive

  • Written informed consent of one parent or a legal representative

Exclusion

Exclusion Criteria:

  • Lack of written informed consent by at least one parent or a legal representative

  • Concurrent disorders such as infection of the upper or lower respiratory tract , nasalsurgery in the past year , respiratory tract abnormalities , immune diseases

  • Use of antihistamines , nasal or systemic corticosteroids , leukotriene modifiers , orcromolyn sodium , on an ongoing basis used in the last six weeks.

Study Design

Total Participants: 40
Study Start date:
December 01, 2016
Estimated Completion Date:
July 31, 2019

Study Description

This is a randomized , double-blind , placebo - controlled , phase 3 , 2 arms , in which patients were selected to receive placebo or a mixture powder composed of three bifidobacteria : Bifidobacterium Longum BB536 ( 3 billion units ) + Bifidobacterium infantis M - 63 ( 1 billion units ) Bifidobacterium breve M + -16 V ( 1 billion units ) . The subjects included in our study are represented by children aged between 4 and 17 years , with seasonal allergic rhinitis moderate and presenting positive skin prick test against parietaria.The participation of each subject in the study was based on evaluation of its clinical history. The recruited patients were divided into two groups according to the drug used.The group A received placebo , while the group B mixture bifidobacteria. The treatment was performed for a period of two months. At the beginning and at the end of therapy several surveys have been carried out , so as to be able to compare results and to draw some preliminary conclusions about the effectiveness of treatment.

Connect with a study center

  • Second University

    Naples, 80138
    Italy

    Active - Recruiting

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