A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression

Last updated: April 25, 2025
Sponsor: Janssen Research & Development, LLC
Overall Status: Completed

Phase

3

Condition

Depression

Treatment

Esketamine Nasal Spray

Clinical Study ID

NCT02782104
CR108149
54135419TRD3008
2015-003578-34
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to assess the safety and tolerability of esketamine nasal spray in participants with treatment-resistant depression (TRD).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Based on the prior study the participant is entering 54135419TRD3008 from: a) FromESKETINTRD3001 (NCT02417064) or ESKETINTRD3002 (NCT02418585) study: Participant hascompleted the induction phase and the 2-weeks follow up phase visit; or Participantscompleted the induction phase and was a responder and study ESKETINTRD3003 isterminated.; b) From ESKETINTRD3003 (NCT02493868) study: (1) Participant relapsedduring the maintenance phase; or (2) Participant was in the induction phase of theESKETINTRD3003 study when the study was terminated and, after completion of theinduction phase, was determined to be a responder; or (3) Participant was in theoptimization or maintenance phases at the time the study was terminated; or (4) or (5) Participants was in the induction phase and after completion of induction phasewas determined to not meet response criteria (1) Participant completedESKETINTRD3004 study (optimization/maintenance phase); or (2) Participant was in theinduction phase of the ESKETINTRD3004 study when the study was terminated and, aftercompletion of the induction phase, was determined to be a responder; or (3)Participant was in the optimization/maintenance phase at the time the study wasterminated; (4) Participant was in the induction phase and did not meet criteria forresponse may be eligible for to be rolled over into 54135419TRD3008. d) FromESKETINTRD3005 (NCT02422186) study: Participant was in the induction phase of theESKETINTRD3005 study at the time enrollment into the ESKETINTRD3004 study was closedand, after completion of the induction phase, was determined to be a responder ordid not meet the criteria for response. e) From ESKETINTRD3006 study (US Study sitesonly) (1) Participant completed the induction phase and was a responder.

  • Participant must be medically stable on the basis of physical examination, vitalsigns, pulse oximetry, and 12-lead Electrocardiogram (ECG) performed predose on theday of the first intranasal treatment session. If there are any abnormalities thatare not specified in the inclusion and exclusion criteria, their clinicalsignificance must be determined by the investigator and recorded in theparticipant's source documents and initialed by the investigator

  • Participant must be medically stable according to the investigator's judgment andknowledge of the subject's medical stability in the parent study. This determinationmust be documented.

  • A woman of childbearing potential must have a negative serum (beta-human chorionicgonadotropin [b-hCG]) predose on the day of the first intranasal treatment session

  • During the study (that is, from the first intranasal treatment session) and for aminimum of 1 spermatogenesis cycle (defined as approximately 90 days) afterreceiving the last dose of intranasal study medication, a man who is sexually activewith a woman of childbearing potential must be practicing a highly effective methodof contraception with his female partner c) must agree not to donate sperm.

Exclusion

Exclusion Criteria:

  • The evaluation of the benefit versus risk of continued esketamine nasal spraytreatment is not favorable for the participant in the opinion of the investigator

  • Since the last study visit in the participant's prior study, participant hassuicidal ideation with intent to act per the investigator's clinical judgment orbased on the Columbia Suicide Severity Rating Scale (C-SSRS) [corresponding to aresponse of "Yes" on Item 4 (active suicidal ideation with some intent to act,without specific plan) or Item 5 (active suicidal ideation with specific plan andintent) in the suicidal ideation module of the C-SSRS] or suicidal behavior per theinvestigator's clinical judgment or based on the C-SSRS (corresponding to any scorehigher than 0 in the suicidal behavior module of the C-SSRS)

  • Participant has positive test result(s) for drugs of abuse (including barbiturates,methadone, opiates, cocaine, phencyclidine, and amphetamine/methamphetamine) predoseon the day of the first intranasal treatment session

  • Participant has any anatomical or medical condition that, per the investigator'sclinical judgment based on assessment, may impede delivery or absorption ofintranasal study drug

  • Participant has taken any prohibited therapies that would not permit administrationof the first intranasal treatment session

Study Design

Total Participants: 1148
Treatment Group(s): 1
Primary Treatment: Esketamine Nasal Spray
Phase: 3
Study Start date:
June 09, 2016
Estimated Completion Date:
December 30, 2022

Study Description

This is an open-label (the researchers and participants know the treatment the participant is receiving) long-term extension study. The study will consist of 2 open-label Phases: 4-week Induction phase (if applicable) and Open-Label Optimization/Maintenance phase (variable). Participants will enter the study Induction Phase from ESKETINTRD3001 (NCT02417064), ESKETINTRD3002 (NCT02418585), ESKETINTRD3003 (NCT02493868), ESKETINTRD3005 (NCT02422186) and ESKETINTRD3006 (US sites only). Participants will enter the study Open-Label Optimization/Maintenance phase from ESKETINTRD3001 (NCT02417064), ESKETINTRD3002 (NCT02418585), ESKETINTRD3003 (NCT02493868) (if appropriate at week 16) or ESKETINTRD3006 (US sites only). In the Open-Label Induction Phase, participants will self-administer flexibly-dosed esketamine nasal spray. During first 4 weeks in Optimization/Maintenance Phase responder participants from the induction phase of study 54135419TRD3008, will continue on the same dose of esketamine nasal spray from the induction phase and have a weekly intranasal treatment session frequency. Participants entering the optimization/maintenance phase from study ESKETINTRD3005 will also have a weekly intranasal treatment session frequency. However, as the ESKETINTRD3005 intranasal study medication is blinded at the time of entry into the current study, the dose of esketamine nasal spray will be administered as outlined in protocol. Participants entering the optimization/maintenance phase from study ESKETINTRD3003 (Direct Entry) or ESKETINTRD3004 who were ongoing in the Optimization, Maintenance, or Optimization/Maintenance phase, respectively, will have the option to have their current intranasal dosing frequency adjusted at the time of entry into 54135419TRD3008 study and should remain on the selected frequency from week 1 to week 4. A one-time dose change will be permitted at study entry. After 4 weeks, esketamine nasal spray treatment sessions will be individualized to either once weekly or once every other week at the fixed 2-week interval (based on clinical global impression - severity [CGI-S] performed at that visit), and every 4 weeks for participants dosed at the 4 week interval. Participants safety will be monitored throughout the study.

Connect with a study center

  • Banfield,
    Argentina

    Site Not Available

  • Instituto Seres

    Buenos Aires, 1111
    Argentina

    Site Not Available

  • Ciudad Autonoma de Buenos Aires,
    Argentina

    Site Not Available

  • Ciudad Autónoma De Buenos Aires,
    Argentina

    Site Not Available

  • Cordoba,
    Argentina

    Site Not Available

  • La Plata,
    Argentina

    Site Not Available

  • Mendoza,
    Argentina

    Site Not Available

  • Rosario,
    Argentina

    Site Not Available

  • Caulfield,
    Australia

    Site Not Available

  • Elizabeth Vale,
    Australia

    Site Not Available

  • Frankston,
    Australia

    Site Not Available

  • Monash Alfred Psychiatry Research Centre

    Melbourne, 3004
    Australia

    Site Not Available

  • Medical University Innsbruck

    Innsbruck, 6020
    Austria

    Site Not Available

  • Vienna,
    Austria

    Site Not Available

  • Aalst,
    Belgium

    Site Not Available

  • Brugge,
    Belgium

    Site Not Available

  • Brussel,
    Belgium

    Site Not Available

  • Psy Pluriel-Pastur

    Bruxelles, 1180
    Belgium

    Site Not Available

  • AZ Maria Middelares

    Gent, 9000
    Belgium

    Site Not Available

  • Jessa Ziekenhuis

    Hasselt, 3500
    Belgium

    Site Not Available

  • Heusden-Zolder,
    Belgium

    Site Not Available

  • Liège,
    Belgium

    Site Not Available

  • Pôle Santé Spa

    Spa, 4900
    Belgium

    Site Not Available

  • Yvoir,
    Belgium

    Site Not Available

  • Hospital Universitario Professor Edgar Santos

    Bahia, 40110-060
    Brazil

    Site Not Available

  • Belo Horizonte,
    Brazil

    Site Not Available

  • Curitiba,
    Brazil

    Site Not Available

  • Fortaleza,
    Brazil

    Site Not Available

  • Instituto Goiano de Neuropsiquiatria

    Goiania, 74093-040
    Brazil

    Site Not Available

  • Instituto Bairral de Psiquiatria

    Itapira, 13970-905
    Brazil

    Site Not Available

  • Passo Fundo,
    Brazil

    Site Not Available

  • Porto Alegre,
    Brazil

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  • Recife,
    Brazil

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  • Rio de Janeiro,
    Brazil

    Site Not Available

  • CEMEC - Centro Multidisciplinar de Estudos Clínicos

    Santo Andre, 09190-510
    Brazil

    Site Not Available

  • Hospital Estadual Mario covas

    Santo André, 09190-615
    Brazil

    Site Not Available

  • Sao Bernardo do Campo,
    Brazil

    Site Not Available

  • Sao Paulo,
    Brazil

    Site Not Available

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    São Bernardo do Campo,
    Brazil

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  • Fundacao Faculdade Regional De Medicina De Sao Jose Do Rio Preto

    São José Do Rio Preto, 15015-500
    Brazil

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  • Hospital Das Clinicas Da Faculdade De Medicina Da USP

    São Paulo, 05409-001
    Brazil

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  • São Paulo,
    Brazil

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  • Instituto De Neurociencias Dr. Quevedo Hospital Sao Sebastiao

    Turvo, 88930-000
    Brazil

    Site Not Available

  • Bourgas,
    Bulgaria

    Site Not Available

  • Kardzhali,
    Bulgaria

    Site Not Available

  • Multiprofile Hospital for Active Treatment dr. Hristo Stambolski EOOD

    Kazanlak, 6100
    Bulgaria

    Site Not Available

  • Pazardzhik,
    Bulgaria

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  • Pleven,
    Bulgaria

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  • Plovdiv,
    Bulgaria

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  • Rousse,
    Bulgaria

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    Bulgaria

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  • Varna,
    Bulgaria

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  • Vancouver, British Columbia
    Canada

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  • Kingston, Ontario
    Canada

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  • Ottawa, Ontario
    Canada

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  • Toronto, Ontario
    Canada

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  • Douglas Mental Health Institute

    Montreal, Quebec H4H 1R3
    Canada

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  • University of Calgary

    Calgary, T2N4Z6
    Canada

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  • Brno,
    Czechia

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  • Clinline s.r.o.

    Hostivice, 25301
    Czechia

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  • Narodni ustav dusevniho zdravi

    Klecany, 25067
    Czechia

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  • Supervize s.r.o.

    Kutna Hora, 28401
    Czechia

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  • Bialbi, spol. s r.o.

    Litomerice, 41201
    Czechia

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  • Plzen,
    Czechia

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  • Prague,
    Czechia

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  • Psychiatricka ordinace

    Praha 1, 11000
    Czechia

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  • Praha 10,
    Czechia

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  • Praha 2,
    Czechia

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  • Praha 6,
    Czechia

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  • Psychiatricka ambulance Strakonice Ambulantni zarizeni PL Lnare

    Strakonice 1, 38629
    Czechia

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  • Parnu Hospital

    Parnu, 800100
    Estonia

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    Estonia

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    Estonia

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  • Kuopio,
    Finland

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  • Clermont-Ferrand Cedex 1,
    France

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  • Douai,
    France

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  • Hôpital Corentin-Celton

    Issy-Les-Moulineaux, 92130
    France

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  • CHU Grenoble

    La Tronche, 38700
    France

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  • CHRU Lille - Hôpital Fontan 1

    Lille, 59000
    France

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  • CHRU Montpellier - Hôpital Lapeyronie

    Montpellier Cedex 5, 34295
    France

    Site Not Available

  • Nantes,
    France

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  • CHU Pasteur - Clinique de Psychiatrie et de Psychologie Médicale

    Nice Cedex 1, 06001
    France

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  • Nîmes,
    France

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  • Paris,
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    Saint-Cyr-Sur-Loire, 37540
    France

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    France

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  • CHU Toulouse - Hôpital de Casselardit

    Toulouse, 31059
    France

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  • Berlin,
    Germany

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    Germany

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  • Gemeinschaftspraxis für Neurologie, Psychiatrie, Psychotherapie

    Cham, 93413
    Germany

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  • Universitatsklinikum Carl Gustav Carcus Dresden

    Dresden, 01307
    Germany

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  • Gemeinschaftspraxis Sallach/Leonhardt

    Gelsenkirchen, 45879
    Germany

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    Halle, 06112
    Germany

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    Mannheim,
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  • Pfaffenhofen,
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  • Neurozentrum Prien

    Prien, 83209
    Germany

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  • Dr. Kenessey Albert Korhaz-Rendelointezet

    Balassagyarmat, 2660
    Hungary

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  • Budapest,
    Hungary

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  • Debrecen,
    Hungary

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    Hungary

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  • Petz Aladar Megyei Oktato Korhaz

    Győr, H-9024
    Hungary

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    Hungary

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  • Pecsi Tudomanyegyetem Klinikai Kozpont

    Pécs, 7623
    Hungary

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    Hungary

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  • Szegedi Tudományegyetem, ÁOK, Szent-Györgyi Albert Klinikai Központ

    Szeged, 6725
    Hungary

    Site Not Available

  • Szekszárd,
    Hungary

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  • Vác,
    Hungary

    Site Not Available

  • U.O.P.I. di Psichiatria

    Catania, 95100
    Italy

    Site Not Available

  • Azienda Ospedaliero Universitaria Careggi

    Firenze, 50134
    Italy

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  • IRCCS Aor San Martino IST

    Genova, 16132
    Italy

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  • Ospedale San Raffaele

    Milano, 20127
    Italy

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  • U.O.C. Di Psichiatria

    Napoli, 80131
    Italy

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  • S.C.D.U. Psichiatria

    Orbassano, 10043
    Italy

    Site Not Available

  • Azienda Ospedaliera di Padova

    Padova, 35128
    Italy

    Site Not Available

  • U.O.C. Di Psichiatria

    Roma, 00193
    Italy

    Site Not Available

  • UOSM Sant'Arsenio

    Sant'Arsenio, 84037
    Italy

    Site Not Available

  • A.O. Universitaria Senese- Ospedale Santa Maria alle Scotte

    Siena, 53100
    Italy

    Site Not Available

  • Korea University Ansan Hospital

    Ansan-Si, 425-707
    Korea, Republic of

    Site Not Available

  • Gwangju,
    Korea, Republic of

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  • Seoul,
    Korea, Republic of

    Site Not Available

  • Kaunas,
    Lithuania

    Site Not Available

  • Hospital Bahagia Ulu Kinta

    Ipoh, 31250
    Malaysia

    Site Not Available

  • Hospital Permai

    Johor Bahru, 81200
    Malaysia

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  • Kuala Lumpur,
    Malaysia

    Site Not Available

  • Centro de Investigación Clínica del Pacífico

    Acapulco, 39670
    Mexico

    Site Not Available

  • Instituto de Investigación en Pro de la Salud Mental

    Durango, 34000
    Mexico

    Site Not Available

  • Guadalajara,
    Mexico

    Site Not Available

  • Leon,
    Mexico

    Site Not Available

  • B&B Investigaciones Médicas

    Mazatlan, 82126
    Mexico

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  • Mexico,
    Mexico

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  • Mexico City,
    Mexico

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  • Monterrey,
    Mexico

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  • San Luis Potosi,
    Mexico

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  • Centro de Atención e Investigación Cardiovascular del Potosí, S.C.

    San Luis Potosí, 78200
    Mexico

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  • Belchatow,
    Poland

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  • Bialystok,
    Poland

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  • Bydgoszcz,
    Poland

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  • Gdansk,
    Poland

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  • Szpital Specjalistyczny im. dr J. Babinskiego SP ZOZ

    Krakow, 30-393
    Poland

    Site Not Available

  • Leszno,
    Poland

    Site Not Available

  • SPZOZ CSK UM w Lodzi Klinika Zaburzen Afektywnych i Psychotycznych

    Lodz, 92-216
    Poland

    Site Not Available

  • Lublin,
    Poland

    Site Not Available

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    Myslowice,
    Poland

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  • Klinika Psychiatryczna WUM Mazowieckie Specjalistyczne Centrum Zdrowia im prof Jana Mazurkiewicza

    Pruszkow, 05-802
    Poland

    Site Not Available

  • NZOZ Podkarpackie Centrum Zdrowia Psychicznego

    Przemysl, 37-700
    Poland

    Site Not Available

  • Specjalistyczny Gabinet Psychiatryczny Kowalkowski Gerard

    Torun, 87-100
    Poland

    Site Not Available

  • NZOZ Prywatna Klinika Psychiatryczna INVENTIVA

    Tuszyn, 95-080
    Poland

    Site Not Available

  • Warszawa,
    Poland

    Site Not Available

  • Spitalul de Psihiatrie Titan Dr. Constantin Gorgos

    Bucuresti, 30442
    Romania

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  • Bratislava,
    Slovakia

    Site Not Available

  • Liptovsky Mikulas,
    Slovakia

    Site Not Available

  • Rimavska Sobota,
    Slovakia

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  • Roznava,
    Slovakia

    Site Not Available

  • Svidnik,
    Slovakia

    Site Not Available

  • Cape Town,
    South Africa

    Site Not Available

  • Pretoria,
    South Africa

    Site Not Available

  • Welgemoed,
    South Africa

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  • Alcorcón,
    Spain

    Site Not Available

  • Hosp. Univ. Infanta Cristina

    Badajoz, 06080
    Spain

    Site Not Available

  • Barcelona,
    Spain

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  • Bilbao,
    Spain

    Site Not Available

  • Hosp. Reina Sofia

    Córdoba, 14004
    Spain

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  • Madrid,
    Spain

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  • Hosp. Puerta Del Sur

    Mostoles, 28938
    Spain

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  • Hosp. Univ. Virgen de La Arrixaca

    Murcia, 30120
    Spain

    Site Not Available

  • Hosp. Regional Univ. de Malaga

    Málaga, 29010
    Spain

    Site Not Available

  • Complexo Hosp. Univ. de Ourense

    Ourense, 32005
    Spain

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  • Oviedo,
    Spain

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  • Palma,
    Spain

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    Spain

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    Ponferrada, 24404
    Spain

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    Spain

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    Spain

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  • Sant Boi de Llobregat,
    Spain

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  • Centro Asist. Dr. Emili Mira I Lopez

    Santa Coloma De Gramanet, 8921
    Spain

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  • Torrevieja,
    Spain

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  • Hosp. Clinico Univ. de Valencia

    Valencia, 46010
    Spain

    Site Not Available

  • Vitoria-Gasteiz,
    Spain

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  • Zamora,
    Spain

    Site Not Available

  • Su Psykiatri Affektiva

    Goteborg, SE-42490
    Sweden

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  • Halmstad,
    Sweden

    Site Not Available

  • Lund,
    Sweden

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  • Skövde,
    Sweden

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  • ProbarE i Stockholm AB

    Solna, SE-17145
    Sweden

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  • Stockholm,
    Sweden

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  • Kaohsiung,
    Taiwan

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    Taiwan

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    Taiwan

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  • National Cheng Kung University Hospital

    Tainan, 704
    Taiwan

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  • Adana,
    Turkey

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    Turkey

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  • Bursa,
    Turkey

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  • Pamukkale University Medical Faculty

    Denizli, 20070
    Turkey

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  • Gaziantep University Sahinbey Research and Training Hospital

    Gaziantep, 27310
    Turkey

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  • Istanbul,
    Turkey

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  • Kocaeli University Medical Faculty

    Kocaeli, 41380
    Turkey

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  • Kucukcekmece/Istanbul,
    Turkey

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  • Manisa Mental Health Hospital

    Manisa, 42250
    Turkey

    Site Not Available

  • Oanakkale,
    Turkey

    Site Not Available

  • Sakarya University Medical Faculty Psychiatry Department

    Sakarya, 54187
    Turkey

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  • Samsun,
    Turkey

    Site Not Available

  • Onsekiz Mart University Medical Faculty Psychiatry Department

    Çanakkale, 17020
    Turkey

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  • Ege Universitesi Tip Fakultesi

    İzmir, 34371
    Turkey

    Site Not Available

  • Callington Road Hospital

    Bristol, BS4 5BJ
    United Kingdom

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  • Abraham Cowley Unit

    Chertsey, KT16 0AE
    United Kingdom

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  • Chesterfield,
    United Kingdom

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  • Derby,
    United Kingdom

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  • NHS Greater Glasgow and Clyde

    Glasgow, G53 7TU
    United Kingdom

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  • London,
    United Kingdom

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    Middlesbrough, TS4 3AF
    United Kingdom

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    United Kingdom

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  • Oxford,
    United Kingdom

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  • Royal Preston Hospital

    Preston, PR2 9HT
    United Kingdom

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  • Birmingham, Alabama
    United States

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  • Little Rock, Arkansas
    United States

    Site Not Available

  • Advanced Research Center Inc

    Anaheim, California 92805
    United States

    Site Not Available

  • Clinicas de Salud del Pueblo, Inc

    Brawley, California
    United States

    Site Not Available

  • Clinical Training and Research Institute

    Burlingame, California 94010
    United States

    Site Not Available

  • CMB Clinical Trials

    Colton, California
    United States

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  • Garden Grove, California
    United States

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  • Glendale, California
    United States

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  • Oakland, California
    United States

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  • Orange, California
    United States

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  • San Diego, California
    United States

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  • Artemis Institute for Clinical Research

    San Marcos, California 92078
    United States

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    United States

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  • University of Connecticut Health Center

    Farmington, Connecticut 06030-6415
    United States

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    United States

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    United States

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  • Meridien Research

    Bradenton, Florida 34201
    United States

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    United States

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  • Florida Clinical Research Center, LLC

    Maitland, Florida 32751
    United States

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  • Miami, Florida
    United States

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    United States

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  • USF, Department of Psychiatry and Behavioral Neurosciences

    Tampa, Florida 33613
    United States

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  • Atlanta, Georgia
    United States

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  • Northwest Behavioral Research Center

    Marietta, Georgia 30060
    United States

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    Roswell, Georgia 30076
    United States

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  • Chicago, Illinois
    United States

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    United States

    Site Not Available

  • Joliet, Illinois
    United States

    Site Not Available

  • Maywood, Illinois
    United States

    Site Not Available

  • Mental Health Chicago

    Schaumburg, Illinois 60194
    United States

    Site Not Available

  • Skokie, Illinois
    United States

    Site Not Available

  • Iowa City, Iowa
    United States

    Site Not Available

  • Phoenix Medical Research, Inc.

    Prairie Village, Kansas 66206
    United States

    Site Not Available

  • Wichita, Kansas
    United States

    Site Not Available

  • Lake Charles, Louisiana
    United States

    Site Not Available

  • Shreveport, Louisiana
    United States

    Site Not Available

  • Baltimore, Maryland
    United States

    Site Not Available

  • Gaithersburg, Maryland
    United States

    Site Not Available

  • CBH Health

    Rockville, Maryland 20850
    United States

    Site Not Available

  • Boston, Massachusetts
    United States

    Site Not Available

  • New Bedford, Massachusetts
    United States

    Site Not Available

  • Beacon Clinical Research

    Quincy, Massachusetts 02169
    United States

    Site Not Available

  • Watertown, Massachusetts
    United States

    Site Not Available

  • Worcester, Massachusetts
    United States

    Site Not Available

  • Rochester Hills, Michigan
    United States

    Site Not Available

  • Washington University School of Medicine

    Saint Louis, Michigan 63110
    United States

    Site Not Available

  • University Of Minnesota

    Minneapolis, Minnesota 55454
    United States

    Site Not Available

  • Psychiatric Care and Research Center (PCRC)

    O Fallon, Missouri 63368
    United States

    Site Not Available

  • O'Fallon, Missouri
    United States

    Site Not Available

  • Saint Charles, Missouri
    United States

    Site Not Available

  • Omaha, Nebraska
    United States

    Site Not Available

  • Cedarhurst, New York
    United States

    Site Not Available

  • New York, New York
    United States

    Site Not Available

  • Staten Island, New York
    United States

    Site Not Available

  • Stony Brook University Medical Center

    Stony Brook, New York 11794
    United States

    Site Not Available

  • University of North Carolina

    Chapel Hill, North Carolina 27514
    United States

    Site Not Available

  • Carolinas Medical Center

    Charlotte, North Carolina 28211
    United States

    Site Not Available

  • Duke University Medical Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Hickory, North Carolina
    United States

    Site Not Available

  • Cincinnati, Ohio
    United States

    Site Not Available

  • Oklahoma City, Oklahoma
    United States

    Site Not Available

  • Allentown, Pennsylvania
    United States

    Site Not Available

  • Media, Pennsylvania
    United States

    Site Not Available

  • Philadelphia, Pennsylvania
    United States

    Site Not Available

  • Scranton Counseling Center

    Scranton, Pennsylvania 18503
    United States

    Site Not Available

  • Lincoln, Rhode Island
    United States

    Site Not Available

  • Providence, Rhode Island
    United States

    Site Not Available

  • Charleston, South Carolina
    United States

    Site Not Available

  • Vanderbilt University Medical Center

    Nashville, Tennessee 37212
    United States

    Site Not Available

  • KRK Medical Research

    Arlington, Texas 76012
    United States

    Site Not Available

  • Austin, Texas
    United States

    Site Not Available

  • Dallas, Texas
    United States

    Site Not Available

  • Houston, Texas
    United States

    Site Not Available

  • Wichita Falls, Texas
    United States

    Site Not Available

  • Neuropsychiatric Associates, LLC - The Woodstock Research Center

    Woodstock, Vermont 5091
    United States

    Site Not Available

  • Charlottesville, Virginia
    United States

    Site Not Available

  • Carilion Clinic-Virginia Tech Carilion School of Medicine

    Roanoke, Virginia 24014
    United States

    Site Not Available

  • Pacific Institute of Medical Sciences

    Bethel, Washington 98011
    United States

    Site Not Available

  • Pacific Institute of Medical Sciences

    Bothel, Washington 98011
    United States

    Site Not Available

  • Pacific Institute of Medical Sciences

    Bothell, Washington 98011
    United States

    Site Not Available

  • Dean Foundation for Health, Research and Education, Inc.

    Middleton, Wisconsin 53562
    United States

    Site Not Available

  • Waukesha, Wisconsin
    United States

    Site Not Available

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