Targeting Anhedonia in Cocaine Use Disorder

Inclusion Criteria:

• be between 18 and 60 years of age

• meet Diagnostic and Statistical Manual V (DSM-5) criteria for current cocaine usedisorder of at least moderate severity (≥ 4 symptoms)

• have at least 1 cocaine positive urine sample during the baseline screening period

• be in acceptable health on the basis of interview, medical history and physicalexam, per the judgment of our study physician

• be able to understand the consent form and provide written informed consent

• be able to provide the names of at least 2 persons who can generally locate theirwhereabouts.

• if female, agree to use an acceptable method of birth control during study (surgicalsterilization, approved hormonal contraceptives, barrier methods with spermicide, orintrauterine device).

Exclusion Criteria:

• current DSM-5 diagnosis for substance use disorder of least moderate severity (≥ 4symptoms), other than cocaine, nicotine, marijuana, or alcohol

• Physical dependence on alcohol requiring medically supervised detoxification, in thejudgment of the study physician

• current amphetamine use (by self-report in past 30 days or positive urine drugscreen), more than 50 lifetime uses of amphetamine, or history of DSM-5 AmphetamineUse Disorder

• a current DSM-5 axis I psychiatric disorder or neurological disease or disorderrequiring ongoing treatment and/or making study participation unsafe

• significant current suicidal or homicidal ideation

• medical conditions contraindicating d-amphetamine (e.g., significant cardiovasculardisease, liver or kidney disease, seizure disorder, hypotension or hypertension)

• taking medications known to have effects on the central nervous system or that couldcause significant drug interactions with d-amphetamine (e.g., clonidine, prazosin)

• having conditions of probation or parole requiring reports of drug use to officersof the court

• impending incarceration

• pregnant or nursing for female patients

• inability to read, write, or speak English

Additional Exclusion Criteria for the functional magnetic resonance (fMRI) Sub-Study (in addition to all listed criteria above for the Main Treatment Study):

• body mass index (BMI) >30, as this may be incompatible with the magnetic resonancescanner gantry

• any retained metals in the body, including implants and metallic substances (e.g.aneurysm clips, retained metal particles in metal workers, magnetic dental implants,ferromagnetic ocular implants, iron-based facial tattoos), as this may cause adverseeffects to participants and interfere with data collection in the MR magnetic field

• inability to tolerate small, enclosed spaces (such as the magnetic resonance scannerbore)