Right Ventricular Metabolism in Pulmonary Arterial Hypertension

Last updated: May 18, 2020
Sponsor: Vanderbilt University Medical Center
Overall Status: Completed

Phase

N/A

Condition

Pulmonary Arterial Hypertension

Williams Syndrome

Stress

Treatment

N/A

Clinical Study ID

NCT02763735
131271
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to use non-invasive imaging to determine the metabolic phenotype of the right ventricle in patients with pulmonary arterial hypertension across a spectrum of disease severity.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Heritable or idiopathic PAH

  • 18 years or older

  • Able to give informed consent

Exclusion

Exclusion Criteria:

  • Pregnancy

  • Type 1 diabetes mellitus

  • Prednisone use

  • PAH associated with any condition other than idiopathic or heritable

  • Implanted ferromagnetic material incompatible with MRI

Study Design

Total Participants: 34
Study Start date:
June 01, 2014
Estimated Completion Date:
June 30, 2019

Study Description

Current medical therapy for pulmonary arterial hypertension (PAH) is aimed at reducing pulmonary vascular resistance (PVR) but not ameliorating right ventricular (RV) failure, the major cause of death. There are no RV-specific therapies currently available for PAH, in part because the pathophysiology of RV failure is poorly understood.

The investigators hypothesize that the RV in PAH develops a distinct metabolic pattern characterized by increased glycolysis, impaired oxidative metabolism and lipid deposition, which are associated with RV failure.

Specific Aim 1. To test the hypothesis that the RV in human PAH exhibits lipid deposition, increased glycolysis and impaired fatty acid oxidation. The investigators will measure RV oxidative metabolism and glycolysis in PAH patients and controls using positron emission tomography 11C acetate and [18F]fluoro-deoxy-D-glucose imaging and measure myocardial lipid accumulation using magnetic resonance spectroscopy imaging.

Specific Aim 2. To test the hypothesis that an abnormal RV metabolic profile is associated with RV dysfunction and reduced exercise capacity in PAH. PET and MRS findings will be correlated with RV function, patient exercise capacity and a blood metabolic profile.

Connect with a study center

  • Vanderbilt University Medical Center

    Nashville, Tennessee 37232
    United States

    Site Not Available

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