Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis

Last updated: June 17, 2017
Sponsor: Tanta University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Intra-abdominal Infections

Soft Tissue Infections

Treatment

N/A

Clinical Study ID

NCT02759497
sbp diagnosis
  • All Genders

Study Summary

One of the most common and serious complications in decompensated cirrhotic patients (DCPs) is bacterial infection.The most common infections in DCPs are cases of spontaneous bacterial peritonitis (SBP), which account for 40% 70% of cases, followed by urinary tract infections, pneumonia and cellulitis.

Serum amyloid A (SAA) and C-reactive protein (CRP) are acute-phase proteins predominantly produced and secreted by hepatocytes. Other cells including lymphocytes, monocytes, and macrophages can also produce these proteins. The induction of SAA and CRP synthesis is triggered by a number of cytokines, chiefly IL-6, which is released from a variety of cell types, but mainly from macrophages and monocytes at inflammatory sites

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • • Decompansated cirrhosis with ascites, defined by a combination of any of thefollowing:

  • Laboratory findings

  • Endoscopic results

  • Ultrasound

  • Histology

Exclusion

Exclusion Criteria:

  • Creatinine>1.5 mg/dl

  • Other infection e.grespiratory,UTI ,gastrointestinal and skin infection.

  • Hepatocellular carcinoma

  • Other extrahepatic malignancy e.g ; chest

  • Any significant psychiatric illness or other medical comorbidity.

  • Any degenerative diseases.

Study Design

Total Participants: 100
Study Start date:
March 01, 2016
Estimated Completion Date:
November 30, 2020

Study Description

Increased serum CRP and SAA levels have been found in a number of disorders, including bacterial infections, malignancies tissue injuries and tissue rejection. Therefore, new studies of early diagnosis, prevention and treatment are needed to improve clinical outcomes.

Connect with a study center

  • Sherief Abd-Elsalam

    Cairo,
    Egypt

    Active - Recruiting

  • Sherief Abd-Elsalam

    Tanta,
    Egypt

    Site Not Available

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