Study Of PF-06817024 In Healthy Subjects, In Patients With Chronic Rhinosinusitis With Nasal Polyps And in Patients With Atopic Dermatitis

Inclusion Criteria

• Healthy male subjects, healthy female subjects of non-childbearing potential, 18-55years of age (Part 1)
• Male subjects, female subjects of non-childbearing potential, female subjects ofchildbearing potential with documented bilateral tubal ligation (tubes tied) orbilateral salpingectomy (tubes removed), 18-65 years of age, and 2 of the followingsymptoms: nasal congestion/obstruction, nasal discharge, face pain/pressure,orreduction/loss of smell (Part 2)
• Male or female subjects between the ages of 18 and 75 years, inclusive withmoderate-to-severe Atopic Dermatitis, agree to avoid prolonged exposure to the sun andnot to use tanning booths, sun lamps, or other ultraviolet light sources during thestudy (Part 3)

Exclusion Criteria:

• Clinically significant diseases (cardiac, psychiatric, autoimmune, renal, etc.),positive urine drug test, fever within 7 days of dosing, active infections within 28days of dosing (Part 1 and 2 and 3)
• History of allergic reaction to topical lidocaine, nasal surgery within 6 months (Part

• Exposure to live or attenuated vaccines, have skin conditions other than AtopicDermatitis, use of JAK inhibitors and biologics (Part 3)