Idiopathic Pre-capillary Pulmonary Hypertension in ESKD Patients

Last updated: April 14, 2016
Sponsor: Toujinkai Hospital
Overall Status: Completed

Phase

N/A

Condition

Scleroderma

Stress

Chest Pain

Treatment

N/A

Clinical Study ID

NCT02743091
PHdialysis
  • Ages 50-85
  • All Genders

Study Summary

This study investigates the prevalence and prognosis of idiopathic pre-capillary pulmonary hypertension (PH) in patients with end-stage kidney disease (ESKD).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Symptoms of dyspnea, hypotension (systolic blood pressure <90mmHg, or syncope.

  • Systolic pressure gradients in tricuspid valve of 40 mmHg or more.

  • In right heart catheterization, precapillary PH was defined as mean pulmonary arterialpressure (PAP) ≥25 mmHg, pulmonary vascular resistance (PVR) ≥3 wood unit, andpulmonary artery wedge pressure (PAWP) ≤15 mmHg.

Exclusion

Exclusion Criteria:

  • Patients with systolic left ventricular dysfunction (left ventricular ejectionfraction [LVEF] <50%), mitral or aortic regurgitation of grade 2 or more, aortic ormitral surface <1.5 cm2, severe anemia (blood hemoglobin <9 g/dl), severe chronicobstructive pulmonary disease defined by percent predicted forced expiratory volume inone second <60%, or lung fibrosis were not enrolled in this study.

  • In right hear catheterization, PAP ≥25 mmHg and PAWP >15 mmHg were diagnosed as postcapillary PH.

Study Design

Total Participants: 1988
Study Start date:
January 01, 2001
Estimated Completion Date:
December 31, 2015

Study Description

Pulmonary hypertension (PH) is a rare cardiovascular disease with progressive and fatal features. PH is classified into the 5 groups, and the prevalence of group 1 pulmonary arterial hypertension, including idiopathic and heritable, is 5 to 15 cases per one million adults and a median survival was reportedly three years. PH found in patients with end-stage kidney disease (ESKD) is classified into group 5, because the pathogenesis and clinical characteristics have not been clarified. The prevalence of PH in patients with ESKD was reportedly around 17~56% based on echocardiographic studies. In this study, we evaluated the incidence of idiopathic pre-capillary PH of ESKD patients by right heart catheterization, and examined the prognosis by following the occurrence of heart failure death.