A Study to Evaluate the Efficacy and Safety of Experimental Drugs ABT- 493/ABT-530 in Adults With Chronic Hepatitis C Virus Genotype 1-6 Infection and Human Immunodeficiency Virus -1 Coinfection (EXPEDITION-2)

Inclusion Criteria:

1. Male or female, at least 18 years of age at time of Screening.
2. Screening laboratory result indicating Hepatitis C virus (HCV) genotype (GT)1-, 2-, 3-, 4-, 5-, or 6-infection.
3. Subject has positive anti-HCV antibody (Ab) and plasma HCV ribonucleic acid (RNA)viral load greater than or equal to 1000 IU/mL at Screening visit.
4. Subjects must be HCV treatment-naïve (i.e., subject has never received a single doseof any approved or investigational anti-HCV medication) or HCV treatment-experienced (subject who has failed prior IFN or pegylated-interferon [pegIFN] with or withoutribavirin [RBV], or sofosbuvir [SOF] plus RBV with or without pegIFN). GT3 subjectsmust be HCV treatment-naïve. Previous HCV treatment must have been completed greaterthan or equal to 2 months prior to Screening.
5. Subjects naïve to antiretroviral treatment (ART) must have CD4+ count greater than orequal to 500 cells/mm^3 (or CD4+ % greater than or equal to 29%) at Screening; orSubjects on a stable ART regimen must have

• CD4+ count greater than or equal to 200 cells/mm^3 (or CD4+ % greater than orequal to 14%) at Screening; and
• Plasma HIV-1 RNA below lower limit of quantification (LLOQ) at Screening and atleast once during the 12 months prior to Screening.

Exclusion Criteria:

1. Recent (within 6 months prior to study drug administration) history of drug or alcoholabuse that could preclude adherence to the protocol in the opinion of theinvestigator.
2. Positive test result at Screening for hepatitis B surface antigen (HBsAg).
3. Positive Human Immunodeficiency virus, type 2 (HIV-2) Ab at Screening.
4. Receipt of any other investigational or commercially available direct acting anti-HCVagents other than sofosbuvir (e.g., telaprevir, boceprevir, simeprevir, paritaprevir,grazoprevir, daclatasvir, ledipasvir, ombitasvir, elbasvir or dasabuvir).
5. Consideration by the investigator, for any reason, that the subject is an unsuitablecandidate to receive ABT-493/ABT-530.