Genetic Study of Immunodeficiency: Search for New Genetic Causes for Primary Immunodeficiencies

Last updated: January 15, 2024
Sponsor: University Children's Hospital, Zurich
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hiv Infections

Primary Immunodeficiency Disorders

Treatment

blood sampling

blood sampling and skin biopsy

blood sampling or mouth swap

Clinical Study ID

NCT02735824
GSI KEK_2015-0555
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Individuals with suspected primary immunodeficiency will be studied and the results compared with healthy controls. Primary immunodeficiency may manifest as recurrent, severe or unusual infections as well as signs and symptoms of immune dysregulation such as autoimmunity or lymphoproliferation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient with suspected PID, healthy relative or healthy volunteer
  • consent

Exclusion

Exclusion Criteria:

  • none

Study Design

Total Participants: 500
Treatment Group(s): 3
Primary Treatment: blood sampling
Phase:
Study Start date:
February 01, 2016
Estimated Completion Date:
December 31, 2027

Study Description

Patients with a suspected immunodeficiency will be identified and invited to participate. Upon agreement, an additional blood sample will be collected when they have their routine bloods taken. If the study participants undergoes anaesthesia for any other reason, a small skin biopsy will be taken as well. Additional samples including blood samples or mouth swabs will be taken from healthy family members. Blood from healthy controls will only be taken when there is a clinical need for blood sampling (or when the study participant is already anaesthetised for any other reason) and not for research purposes only.

Connect with a study center

  • Division of Immunology

    Zurich, ZH 8032
    Switzerland

    Active - Recruiting

  • University of Basel Children's Hospital

    Basel, 4031
    Switzerland

    Active - Recruiting

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