Memory Improvement Through Nicotine Dosing (MIND) Study

Inclusion Criteria:

1. Participant must have a subjective memory concern as reported by participant, studypartner, or clinician

2. Abnormal memory function documented by scoring within the education adjusted rangeson the Logical Memory II subscale (Delayed Paragraph Recall) from the WechslerMemory Scale - Revised:

• less than or equal to 11 for 16 or more years of education

• less than or equal to 9 for 8 - 15 years of education

• less than or equal to 6 for 0 - 7 years of education

3. Mini-Mental State Exam score between 24 and 30, inclusive

4. Clinical Dementia Rating (CDR) Global = 0.5. Memory Box score must be at least 0.5

5. General cognition and functional performance sufficiently preserved such that adiagnosis of Alzheimer's disease dementia cannot be made by the site physician atthe time of the screening visit

6. Age 55-90 (inclusive)

7. Stable permitted medications for 4 weeks or longer as specified in Section 6,including:

• Memantine and cholinesterase inhibitors are allowable if stable for 12 weeks priorto screen

8. Geriatric Depression Scale score of less than or equal to 14

9. Study Partner is available who has frequent contact with the participant (e.g. anaverage of 10 hours per week or more), and can accompany the participant to mostvisits to answer questions about the participant

10. Adequate visual and auditory acuity to allow neuropsychological testing

11. Good general health with no additional diseases/disorders expected to interfere withthe study

12. Participant is not pregnant, lactating, or of childbearing potential (i.e. womenmust be two years post-menopausal or surgically sterile)

13. Completed six grades of education or has a good work history

14. Fluent in English or Spanish

Exclusion Criteria:

1. Regular use of tobacco products within the past year, such as smoking (cigarettes,pipes, cigars, etc.) or use of other nicotine products (chewing tobacco,e-cigarettes, nicotine patches, gum, sprays, etc.).

2. Any significant neurologic disease such as Alzheimer's disease dementia, Parkinson'sdisease, multi-infarct dementia, Huntington's disease, normal pressurehydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder,subdural hematoma, multiple sclerosis, or history of significant head traumafollowed by persistent neurologic deficits or known structural brain abnormalities.

3. Major depression, bipolar disorder as described in DSM-V within the past 1 year orpsychotic features, agitation or behavioral problems within 3 months, which couldlead to difficulty complying with the protocol

4. History of schizophrenia (DSM V criteria)

5. History of alcohol or substance abuse or dependence within the past 2 years (DSM Vcriteria)

6. Clinically significant or unstable medical condition, including uncontrolledhypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal,hepatic, endocrine, or other systemic disease in the opinion of the Investigator,may either put the participant at risk because of participation in the study, orinfluence the results, or the participant's ability to participate in the study.

7. Has had a history within the last 5 years of a primary or recurrent malignantdisease with the exception of non-melanoma skin cancers, resected cutaneous squamouscell carcinoma in situ, basal cell carcinoma, cervical carcinoma in situ, or in situprostate cancer with normal prostate-specific antigen post-treatment

8. Clinically significant abnormalities in B12 or TFTs (Thyroid Function Tests) thatmight interfere with the study. A low B12 is exclusionary, unless the requiredfollow-up labs (homocysteine (HC) and methylmalonic acid (MMA)) indicate that it isnot physiologically significant.

9. Clinically significant abnormalities in screening laboratories or ECG.

10. Residence in skilled nursing facility.

11. Use of any excluded medication as described in the protocol, including:

• Use of centrally acting anti-cholinergic drugs

• Use of any investigational drugs within 30 days or 5 half-lives, whichever islonger, prior to screening.

12. For CSF sub-study participants, a current blood clotting or bleeding disorder, orsignificantly abnormal PT or PTT (partial thromboplastin time) at screening

13. For MRI sub-study participants, contraindications for MRI studies, includingclaustrophobia, the presence of metal (ferromagnetic) implants, or cardiacpacemaker.

14. Patients whom the Site PI deems to be otherwise ineligible.