Topical Garlic Concentrate for Alopecia Areata in Children

Phase

Condition

Hair Loss

Alopecia

Treatment

N/A

Clinical Study ID

NCT02691117

1000050555

Ages 4-18
All Genders

Study Summary

Management of pediatric alopecia is particularly challenging given the chronicity of the condition, limited therapeutic response and devastating psychological effects. There is a paucity of safe and effective therapies in this population.

The investigators propose to conduct and open label, prospective cohort pilot study using topical garlic concentrate ( GarlicRich) for treatment of children with alopecia areata. Study medication will be applied topically on affected area of the skin daily for 6 months. Follow up visits will occur monthly to access the efficacy and safety of the proposed treatment .

Eligibility Criteria

Inclusion

Inclusion Criteria:

Children aged 4 years and older up to 18 years of age
Patches of alopecia areata that affect less than 50% of the scalp.
Alopecia of at least 1 year duration without evidence of regrowth
Informed written consent

Exclusion

Exclusion Criteria:

Any children experiencing significant spontaneous regrowth of terminal hair at thebaseline visit.
Any children treated with a topical, (including shampoos with active ingredients likeminoxidil or clobetasol), intralesional or systemic agent likely to cause regrowth inalopecia areata within the past month from the baseline visit and during study period.
Children with history of hypersensitivity to garlic.
Children with widespread alopecia areata as alopecia totalis, universalis, ophiasis ordiffuse Alopecia Areata.

Study Design

January 10, 2016

December 01, 2017

Study Description

The investigators are planning to enroll in the study 20 participants at Sickkids.

It is an open label, prospective cohort pilot study. Patients enrolled in the study will be followed at the Hospital for Sick Children for 6 months. Participants will come for the study visits every month (7 study visits). During each study visit two investigators will independently access patient's hair density and calculate the SALT score (Severity of Alopecia Tool Score), using the participant's digital photographs.

Patients will be provided with the study medication for all duration of the study.

The results of the treatment will be compared with the baseline data ( pictures/ scores/ hair density) to evaluate the efficacy and safety of garlic concentrate in children with patchy alopecia areata.

Connect with a study center

Th Hospital for Sick Children
Toronto, Ontario M5G1X8
Canada
Site Not Available

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