Double-masked Study of PG324 Ophthalmic Solution in Patients With Open-angle Glaucoma or Ocular Hypertension

Inclusion Criteria:

1. 18 years of age or older (19 years of age or older in Canada)

2. Diagnosis of open angle glaucoma (OAG) or ocular hypertension(OHT) in both eyes

3. Unmedicated intraocular pressure >20mmHg and <36mmHg in both eyes at 2 qualificationvisits

4. Best corrected visual acuity (BCVA) equivalent to 20/200 Snellen or better

5. Able to give informed consent and follow study instructions

Exclusion Criteria: Ophthalmic:

1. Clinically significant ocular disease

2. Pseudoexfoliation or pigment dispersion component glaucoma, history of angle closureor narrow angles

3. Unmedicated intraocular pressure ≥36mmHg in either eye or use of more than 2 ocularhypotensive medications within 30 days of screening

4. Known hypersensitivity to any component of the formulation or latanoprost

5. Previous glaucoma surgery or refractive surgery

6. Ocular trauma within 6 months prior to screening

7. Any ocular surgery or non-refractive laser treatment within 3 months prior toscreening

8. Recent or current ocular infection or inflammation in either eye

9. Use of ocular medication in either eye of any kind within 30 days of screening andthroughout of the study

10. Mean central corneal thickness >620µm at screening in either eye

11. Any abnormality preventing reliable applanation tonometry of either eye Systemic:

12. Clinically significant abnormalities in lab tests at screening

13. Clinically significant systemic disease

14. Participation in any investigational study within 60 days prior to screening

15. Systemic medication that could have had a substantial effect on IOP within 30 daysprior to screening, or anticipated to be used during the study

16. Women of childbearing potential who were pregnant, nursing, planning a pregnancy, ornot using a medically acceptable form of birth control