Oxytocin Administration in BDD and OCD

Inclusion Criteria:

• Treatment-seeking adult males and females ≥ 18 years of age

• Meets DSM-IV criteria for principal BDD (for BDD group) or principal OCD (for OCDgroup), as determined by Structured Clinical Interview for DSM-IV (SCID) diagnosticinterview

• For females only: must be taking low-dose oral contraceptive pills, as defined bymonophasic pills containing <50 mcg ethinyl estradiol

• For healthy volunteers only: does not meet current DSM-IV diagnosis of any Axis Idisorder

Exclusion Criteria:

• Participants in the BDD group will be excluded if they have a comorbid diagnosis ofOCD and participants in the OCD group will be excluded if they have a comorbiddiagnosis of BDD.

• Current diagnosis of schizophrenia, psychotic disorder, bipolar disorder, substanceabuse or substance dependence. All other Axis I comorbidities will be permitted tofoster the accrual of a clinically relevant sample.

• Significant nasal pathology (e.g., atrophic rhinitis, history of hypophysectomy,recurrent nosebleeds)

• Smokers who smoke ≥ 15 cigarettes daily

• Serious medical illnesses

• Active homicidal or suicidal ideation

• Concurrent use of psychotropic medications

• Steroid or hormone use (except low-dose oral contraceptive pills for females, which isallowed)

• For females only: positive urine pregnancy test and use of high doseestrogen/progestin pills (low dose estrogen/progestin oral contraceptives will beallowed due to stability of hormone levels during active phase)

• For healthy volunteers only: any current DSM-IV Axis I disorder