Early Postoperative Cognitive Dysfunction After Closed Loop Anesthesia vs Inhalational Anesthesia or TIVA

Last updated: July 3, 2016
Sponsor: University of Foggia
Overall Status: Completed

Phase

N/A

Condition

Mild Cognitive Impairment

Mental Disability

Memory Loss

Treatment

N/A

Clinical Study ID

NCT02656901
43/CE/2014
  • Ages > 18
  • All Genders

Study Summary

This study is designed to test the hypothesis that closed loop system reduces post operative cognitive dysfunction incidence 15 min after anesthesia more than desflurane, sevorane, total intravenous anesthesia manually guided by bispectral index in urologic surgical patients.

The secondary aim is to evaluate the postoperative cognitive impairment in in elderly vs younger surgical patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients aged above 18 years

  • Patients undergoing elective urologic surgery under general anesthesia expected 2hours

  • American Society of Anesthesiology physical status II- III

Exclusion

Exclusion Criteria:

  • Patients with body mass index greater than 30,

  • Patients with clinically significant cardiopulmonary, hepatic, renal disorders,neurological, psychiatric or metabolic disease

  • Patients unable to read and write and with impaired hearing

Study Design

Total Participants: 132
Study Start date:
January 01, 2016
Estimated Completion Date:
June 30, 2016

Study Description

Postoperative cognitive dysfunction (POCD) is a transient cognitive impairment manifested by compromised memory and concentration with altered performance on intellectual tasks that can affect patients of any age but it is more frequent in advanced age people after anesthesia.

Recently clinical research has demonstrated the efficacy of computer- controlled endovenous drug delivery system guided by bispectral index score (BIS) of the electroencephalogram as the control variable. The BIS closed loop (CL) titration of propofol and remifentanyl target control infusion provides clinically adequate anesthesia with stability of cardiovascular parameters and favorable patients outcomes, including decreasing drug consumption and shortened postoperative recovery times when compared with manual control infusion.

Connect with a study center

  • University of Foggia

    Foggia, 71122
    Italy

    Site Not Available

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