Phase Ib Study of Anetumab Ravtansine in Combination With Pemetrexed and Cisplatin in Mesothelin-expressing Solid Tumors

Inclusion Criteria:

• Subjects may be male or female, and must be aged =/>18 years on the date of signingthe informed consent form.

• Subjects must have histologically confirmed, unresectable, locally advanced ormetastatic pleural or peritoneal predominantly (>50% of tumor component) epithelialmesothelioma or nonsquamous non-small-cell lung cancer (NSCLC). Bothchemotherapy-naive and previously treated subjects will be eligible; however, newlydiagnosed NSCLC subjects eligible for FDA-approved therapies should have received thesame before enrollment (e.g. subjects with epidermal growth factor receptor [EGFR]-mutated and anaplastic lymphoma kinase [ALK]-translocated NSCLC should havereceived FDA-approved targeted therapies).

• Subjects must have at least 1 measurable or evaluable tumor lesion according to RECIST 1.1 (for nonsquamous NSCLC) or mRECIST (for epithelial pleural mesothelioma). Subjectswith resected primary tumors who have documented metastases are eligible.

• Subjects must have a life expectancy of at least 12 weeks.

• Subjects must have ECOG (Eastern Cooperative Oncology Group performance Status of 0 or 1

• Subjects must have adequate bone marrow, liver, kidney, and coagulation functions.

Exclusion Criteria:

• Subjects who have a previous or concurrent cancer that is distinct in primary site orhistology from the cancer being evaluated in this study, or any previous cancercuratively treated >3 years before the start of study Treatment.

• Subjects who have a history or current evidence of bleeding disorder, i.e. anyhemorrhage / bleeding event of CTCAE (Common Terminology Criteria for Adverse Events)Grade ≥2 within 4 weeks before the start of study Treatment.

• Subjects who have new or progressive brain or meningeal or spinal metastases.

• Subjects who have a history or current evidence of uncontrolled cardiovascular diseasei.e. NYHA (New York Heart Association) Class III or IV.

• Subjects who have a history or current evidence of uncontrolled hypertension definedas systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg atscreening despite optimal medical management.

• Subjects who have a history or current evidence of malignant biliary obstructionrequiring biliary stent.

• Subjects who have had solid organ or bone marrow Transplantation.

• Subjects who have a history of hypersensitivity to any of the study drugs or theirexcipients, or a history of severe hypersensitivity to any other Antigen.

• Subjects who have a history of human immunodeficiency virus (HIV) infection orsubjects who have an active hepatitis B virus (HBV) or hepatitis C virus (HCV)infection requiring treatment.

• Subjects who have an active clinically serious infection of CTCAE Grade ≥2 ornon-healing wound unrelated to the primary Tumor.

• Subjects who have received systemic cancer therapy, radiotherapy, investigational drugtreatment outside of this study within 4 weeks before the start of study treatment,granulocyte colony stimulating factors, (G-CSF) or granulocyte macrophage-stimulatingfactors (GM-CSF), erythropoietin-stimulating agents within 3 weeks before the start ofgeneral screening, drugs with known renal toxicity and strong cytochrome P450 3A4 (CYP3A4) inhibitors or strong CYP3A4 inducers within 2 weeks before the treatment.

• Subjects who have started oral or parenteral anticoagulation therapy within 2 weeksbefore the start of anetumab ravtansine until end of treatment visit.