Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock

Last updated: July 28, 2019
Sponsor: China Medical University Hospital
Overall Status: Completed

Phase

N/A

Condition

Circulation Disorders

Heart Failure

Heart Attack (Myocardial Infarction)

Treatment

N/A

Clinical Study ID

NCT02633358
CMUH104-REC3-058
  • Ages 18-100
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Acute myocardial infarction complicated with cardiogenic shock trigger IL-6, the strong inflammatory response, result in multiple organ failure, even death.

While therapeutic hypothermia,to expect the possibility of anti-inflammatory effect via IL-6 bi-phasic effect and IL-10 , to improve the multiple organ failure, to increase survival rate and well cerebral performance.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age between 18-100 years

  • Cardiogenic sock including initial lactate level >18 mg/dL, necessary of vasopressorto keep mean artery pressure >65mmHg after adequate fluid supply, and signs of reducedcardiac output including disturbance consciousness, cold limbs, decreased urineoutput, acute pulmonary congestion and so on.

Exclusion

Exclusion Criteria:

  • Patient or family refuse

  • Metastatic cancer

  • Pregnancy

Study Design

Total Participants: 141
Study Start date:
November 01, 2015
Estimated Completion Date:
August 18, 2018

Study Description

Despite emergency coronary revascularization coupled with medical stabilization, intra-aortic balloon pump have significantly improved survival in patients with cardiogenic shock complicating acute myocardial infarction, mortality still remains excessively high, being actually about 30-50%. Future research should focus on new therapeutic strategies, aimed to further decrease mortality rate of these patients or improve possible hospitalization and prognosis.

Heart pumping failure result in cardiogenic shock. Increased LA filling pressure result in acute pulmonary edema, hypoxemic respiratory failure, even congestive kidney and congestive liver. Decreased stroke volume result in hypoperfusion obviously direct induce acute renal failure, disturbance consciousness and lactate accumulation, even, shock liver. Multiple organ failure is the major mortality in the patients suffered from cardiogenic shock after acute myocardial infarction.

Cardiogenic shock remains the leading cause of death in patients hospitalized for myocardial infarction . Systemic inflammation , especially endovascular Interleukin-6, triggered by Tumor necrosis factor-alfa and Interleukin-1 beta result in inappropriate vasodilatation is observed in many patients with cardiogenic shock and may contribute to an excess mortality rate. In recent study, interleukin-6 represented a reliable independent early prognostic marker of 30-day mortality.

Therapeutic hypothermia (34℃) increase stroke volume, reduce muscle oxygen consumption and enhance anti-inflammatory action . The mechanism of anti-inflammatory effect for therapeutic hypothermia in cardiogenic shock is still unclear, need to further study in clinical trial. Furthermore, this study will provide new strategy to increase survival rate in cardiogenic shock.

Connect with a study center

  • China Medical University Hospital

    Taichung,
    Taiwan

    Site Not Available

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