Phase
Condition
Congestive Heart Failure
Hyponatremia
Heart Failure
Treatment
N/AClinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age 18 years or older
Current hospitalization for chronic congestive heart failure with admission up to 48hours prior to inclusion.
Chronic heart failure will be defined as requiring treatment for a minimum of 30 daysprior to current admission, NYHA Class III or IV at the time of hospitalization, andleft ventricular ejection fraction less than 40% within one year or evidence of heartfailure with preserved ejection fraction and evidence of diastolic dysfunction onechocardiogram.
Admitted with clinical decompensated heart failure based on history, physical exam,and parameters indicating extracellular volume expansion such as including JVP ≥ 8 cmof water and 1+ or greater peripheral edema
Is able to be dosed with study medication within six (6) hours of first dose of IVdiuretics
Exclusion
Exclusion Criteria:
Baseline severe hypotension (Mean arterial pressure < 55 mm Hg)
Creatinine clearance less than 20 ml/min or creatinine greater than 2.5 mg/dl.
Serum sodium less than 128 meq/L.
Serum Potassium < 3.0 meq/L.
Known adverse reaction to metolazone
Inability to take oral medications
Severe Aortic Stenosis (AVA < 0.8cm2)
History of Hypertrophic obstructive cardiomyopathy
Metastatic Carcinoma per history
Severe COPD, FEV < 1L
Severe dyspnea requiring prolonged CPAP,BIPAP or intubation
Study Design
Study Description
Connect with a study center
Aultman Health Foundation
Canton, Ohio 44710
United StatesSite Not Available
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