This randomized Clinical trial was approved by the ethics committee of South Egypt Cancer
Institute, Assuit University, Assuit, Egypt. Sixty patients aged 18 - 60 years, American
Society of Anesthesiologists (ASA) class I-II, with body weight of 50 - 90 kg and arranged
for modified radical mastectomy) were enrolled in this study. Patients with a history of
bleeding diathesis, relevant drug allergy, opioid dependence, morbid obesity, sepsis, prior
surgery in the supraclavicular, infraclavicular or axillary regions, alcohol or drug abuse
and those with psychiatric illnesses that would interfere with perception and assessment of
pain were excluded from the study.
Preoperatively, patients were taught how to evaluate their own pain intensity using the
Visual Analog Scale (VAS), scored from 0-10 (where 0= no pain and 10=worst pain imaginable),
and whenever (during the follow up period) VAS points to a value ≥ 3. Analgesia comprised PCA
with an initial morphine bolus of 0.1mg/kg once pain expressed by the patient or if VAS ≥ 3
followed by 1mg boluses with a lockout period a 5 minute. The time to first request for
analgesia and the total analgesic consumption in the first 24 hours were recorded.
On arrival to the operating room, an intravenous line was inserted. Monitoring included
electrocardiography (ECG), non-invasive blood pressure (NIBP), arterial oxygen saturation
(Sao2) and end-tidal carbon- dioxide were applied.
Anesthesia was induced for all participating patients with 2 μg/kg fentanyl, 2-3 mg/kg
propofol and 1.5 mg/kg lidocaine. Endotracheal intubation was facilitated by 0.15 mg/kg
cis-atracurium. Anesthesia was maintained by 1-1.5 MAC isoflurane in 50% oxygen / air mixture
and 0.03 mg/kg cisatrcurium respectively in ventilation parameters to maintain on ETco2 of
approximately 35- 40 mmHg. Ultrasound guided pecs block then performed
Patients were randomly assigned into 2 groups (using a randomization-computer program), 30
patients in each:
Group I (Bupivacaine group): patients were given ultrasound guided, modified Pecs block with
30 mL of 0.25% bupivacaine divided into 10 ml injected between the two pectoralis muscles on
the interfascial plane, and 20 ml injected between the Pectoralis minor muscle and the
serratus muscle.
Group II (Bupivacaine + ketamine group) : patients were given ultrasound guided, modified
Pecs block with 30 ml of 0.25% bupivacaine plus ketamine (1 mg/kg) divided into 10 ml
injected between the two pectoralis muscles on the interfascial plane , and 20 ml injected
between the Pectoralis minor muscle and the serratus muscle.
Modified Pecs block was performed under general anesthesia, and 15 min. before skin incision.
We performed the modified Pecs block or the " Pecs II block" by using a two needle approach
instead of one. The first puncture is a Pecs I block with 10 ml of local anesthetic injected
between the two pectoralis muscles, and the second puncture injects 20 ml of local anesthetic
between the Pectoralis minor muscle and the serratus muscle. This breaks through the
'axillary door' and will reach the long thoracic nerve and reliably at least two intercostal
nerves.
We used a broadband linear array probe, with an imaging depth of 3-4cm. starting from the
lateral third of the clavicle and moving distally and laterally to the mid axillary line.
At the end of surgery, reversal of muscle relaxant was done using neostigmine (0.04 mg/kg)
and atropine (0.01 mg/kg). After extubation; all patients were transmitted to post anesthesia
care unit (PACU).
Each patient in both groups was followed up and assessed at baseline, 1h, 2h, 4h, 6h , 12h ,
24h, 48h postoperatively for: Vital signs (The patients' heart rate, non invasive arterial
blood pressure, respiratory rate and oxygen saturation), Post operative pain where the
severity of pain was assessed using VAS score, the time to first request of rescue analgesia
and total morphine consumption in the 48 hours.
Potential side effects, including, sedation by sedation score of 0-4 (0 = patient fully
awake; 1 = patient somnolent and responsive to verbal commands; 2 = patient somnolent and
responsive to tactile stimulation; and 3 = patient asleep and responsive to painful
stimulation; 4 = not arousable), chest pain, nausea, vomiting (treated by IV boluses of
metochlopromide 10 mg), and psychological complications (hallucination, delirium, dreams,
nystagmus, dissociative effects) were also recorded.