Robotic Lobectomy vs. Thoracoscopic Lobectomy for Early Stage Lung Cancer: RCT

Last updated: December 5, 2024
Sponsor: St. Joseph's Healthcare Hamilton
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cardiac Surgery

Open Heart Surgery

Non-small Cell Lung Cancer

Treatment

Video-assisted thoracoscopic surgery

Robotic thoracic surgery

Clinical Study ID

NCT02617186
BFCRS-RP-003-1508-31
  • Ages > 18
  • All Genders

Study Summary

During video-assisted thoracoscopic lobectomy (VATS), the surgeon inserts a small camera attached to a thoracoscope that puts the image onto a video screen. Instruments are inserted via small incisions, and the lung resection is completed. Robotic thoracic surgery (RTS) uses a similar minimally invasive approach, but the very precise instruments involved with RTS allow the surgeon to view the lung using 3-dimensional imaging. The instruments give the surgeons increased range of motion during the surgery, and research demonstrates that RTS has a less steep learning curve as compared to VATS. Both VATS and RTS demonstrated better results as compared to traditional thoracotomy (open surgery). However, Robotic lobectomy has not yet been compared directly to video-assisted thoracoscopic lobectomy (VATS) in a prospective manner.

There are two major barriers against the widespread adoption of robotic thoracic surgery. The first barrier is the lack of high-quality prospective data. To our knowledge, there are no prospective trials comparing VATS to RTS for early stage lung cancer. The second major barrier to the widespread adoption of robotic technology in thoracic surgery is the perceived higher cost of Robotic lobectomy. To address these barriers, the investigators will undertake the first randomized controlled trial comparing Thoracoscopic Lobectomy to Robotic Lobectomy for early stage lung cancer.

Prospective randomization will eliminate the biases of retrospective data and will serve to determine whether there exist any advantages to Health Related Quality of life (HRQOL) or patient outcomes in favour of Robotic Lobectomy over VATS Lobectomy. Furthermore, through a prospective cost-utility analysis, this trial will provide the highest quality data to evaluate the true economic impact of robotic technology in thoracic surgery in a Canadian health system.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age >/= 18 years

  2. Clinical stage I, II or IIIa non-small cell lung cancer (NSCLC)

  3. Candidates for minimally invasive pulmonary lobectomy, as determined by theoperating surgeon.

Exclusion

Exclusion Criteria:

  1. Clinical stage IIIb or IV NSCLC

  2. Not a candidate for minimally invasive surgery.

Study Design

Total Participants: 592
Treatment Group(s): 2
Primary Treatment: Video-assisted thoracoscopic surgery
Phase:
Study Start date:
January 01, 2016
Estimated Completion Date:
September 30, 2031

Connect with a study center

  • McMaster University / St. Joseph's Healthcare Hamilton

    Hamilton, Ontario L8N 4A6
    Canada

    Active - Recruiting

  • Toronto General - University Health Network

    Toronto, Ontario
    Canada

    Site Not Available

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