Severe Sepsis in Children - IMPRESS-C

Inclusion Criteria: For all patients:

• Ability to assent (age 7-17 at time of participation in the study)
• If taking antihypertensive medication, prescribing practitioner's written approval toparticipate For sAKI patients:
• Hospitalization with a diagnosis of sepsis from 1998-2014
• Severe AKI as defined by the pEDRIFLE criteria during incident sepsis admission
• Participation in cognitive survey study with completion of the PedsQL survey For healthy control patients:

• Patients from the neurology service undergoing MRI with gadolinium as a part of theirclinical care

Exclusion Criteria: For all patients:

• Known pre-existing CKD as defined by history of kidney transplant or long-termdialysis
• Age greater than 17 years at the time of incident sepsis admission
• AKI from primary kidney disease including acute glomerulonephritis and obstructiveuropathy
• Pregnancy at the time of enrollment
• Known or suspected allergy to gadolinium based contrast
• Known or suspected allergy to iodohippurate will be excluded from RPF measurement withiodohippurate
• Heart failure or condition whereby the administration of 0.9% normal saline would becontraindicated
• If taking antihypertensive medication, lack of prescribing practitioner's writtenapproval to participate For healthy control patients:
• Chronic kidney disease
• History of acute kidney injury or GFR <100 History of chronic illnesses deemed topredispose to renal or cardiovascular dysfunction or abnormalities Suspicion ofinfection
• Neuro-vascular history such as encephalitis, meningitis, vascular anomalies of thebrain or spinal cord or cerebrovascular infarct or ischemia will be excluded .
• No indication for gadolinium administration for MRI