Effects of rTMS Based on Neural Activation in Language Performance in Stroke Patients With Non-fluent Aphasia

Last updated: June 30, 2025
Sponsor: Seoul National University Bundang Hospital
Overall Status: Completed

Phase

N/A

Condition

Stroke

Speech Disorders

Cerebral Ischemia

Treatment

MagPro magnetic stimulator (sham)

MagPro magnetic stimulator (HF rTMS)

MagPro magnetic stimulator (LF rTMS)

Clinical Study ID

NCT02591719
B-1507-308-006/P2
  • Ages 18-80
  • All Genders

Study Summary

The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18-80 yrs old

  • Right-handed

  • Radiologically confirmed left hemisphere stroke within 6 months

  • Fluent in Korean

  • First ever stroke

  • Non-fluent (motor-dominant) aphasia

  • Written informed consent

Exclusion

Exclusion Criteria:

  • Previous medical histories of stroke, cerebral vascular operation,

  • Seizure

  • Patients with traumatic brain injury

  • Unable to perform the language task

  • Severe cognitive impairment (MMSE less than 16)

  • Skin lesion in the stimulation site of scalp

  • Metal implants in the body (cardiac pacemaker or aneurysm clip)

  • Pregnancy, breastfeeding

Study Design

Total Participants: 36
Treatment Group(s): 3
Primary Treatment: MagPro magnetic stimulator (sham)
Phase:
Study Start date:
November 01, 2015
Estimated Completion Date:
October 20, 2023

Study Description

Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area.

In the present randomized controlled trial, investigators will perform fNIRS prior to rTMS treatment to select the stimulation method. Stimulation site (perilesional or contralesional) and frequency (excitatory high or inhibitory low) will be determined by activation pattern from the fNIRS with language task in individual patients.

The patient who shows a dominant neural activity at perilesional Broca's area on fNIRS scanning will be randomly allocated into two groups: high frequency stimulation group and sham stimulation group. If a patient shows a dominant neural activity at contralesional homologs of Broca's area on fNIRS scanning, the patient will be allocated to a low frequency stimulation group.

Connect with a study center

  • Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital

    Seongnam-si, Korea, Gyeonggi-do 463-707
    Korea, Republic of

    Site Not Available

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