Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion

Last updated: October 16, 2024
Sponsor: Imperial College London
Overall Status: Active - Recruiting

Phase

N/A

Condition

Colorectal Cancer

Digestive System Neoplasms

Rectal Cancer

Treatment

Blood sample (mrEMVI positive patient)

Blood sample (mrEMVI negative patient)

Clinical Study ID

NCT02579278
DOCUMAS: 23HH8182
  • Ages > 16
  • All Genders

Study Summary

This study does not involve randomization or treatment. Eligible patients have colorectal adenocarcinoma with no metastases eligible for curative surgery. A pre operative staging scan must have been completed within 6 weeks prior to surgery. Two x 20ml blood samples will be taken from each patient, one prior to and one during or within 24hrs after surgery. Patients are annually followed up to 3 years.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Have a biopsy-confirmed colorectal adenocarcinoma

  2. Is eligible for curative surgery

  3. Has no metastatic disease on CT scan

  4. Has completed pre-operative staging scan within six weeks prior to surgery

  5. Have provided written informed consent to participate in the study

  6. Be aged 16 years or over

Exclusion

Exclusion Criteria:

  1. Have metastatic disease (including resectable liver metastases)

  2. Have a synchronous second malignancy

  3. Are contraindicated for any imaging able to determine EMVI status

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Blood sample (mrEMVI positive patient)
Phase:
Study Start date:
November 01, 2015
Estimated Completion Date:
December 31, 2029

Study Description

A multicentre observational study, ctDNA aims to provide the evidence base for metatstatic disease being caused by vascular methods of spread by determining if there is a link between EMVI status and ctDNA

Connect with a study center

  • Queen Elizabeth the Queen Mother Hospital

    Margate, Kent CT9 4AN
    United Kingdom

    Active - Recruiting

  • St Mary's Hospital (Imperial)

    Hammersmith, London W2 1NY
    United Kingdom

    Active - Recruiting

  • Royal Marsden Hospital NHS Foundation Trust

    London/Surrey, Surrey SM2 5PT
    United Kingdom

    Site Not Available

  • Royal Marsden Hospital NHS Foundation Trust

    Sutton, Surrey SM2 5PT
    United Kingdom

    Active - Recruiting

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