A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation

Inclusion Criteria:

• Korean male aged between 19 and 65

• Both patient and his partner given their informed and written consents

• Patient who has persisted for at least 6 months and is willing to retain therelationship during this study

• Patient diagnosed with premature ejaculation according to DSM-V

• Patient whose score in PEDT (Korean version) is 11 and more

• Patient who are willing to try 4 and more intercourse attempts for Run-in period andhe has experienced 75%-100% of the IELT within one minute or less of vaginalpenetration

• Patient whose personal distress in PEP is 'moderate' and over.

• Patient who is willing to participate in the study by the end and are cooperative (trying 4 and more intercourse attempts between each visit and able to postponescheduled elective surgery)

• Patient who is willing to complete a patient diary and questionnaires

Exclusion Criteria:

• Patient who has a medical history including neurological disorders, infectiousdiseases, damage, surgery or medication history and that is judged to be related topremature ejaculation

• Patient who has participated into other trials within 90 days before this study

• Patient who is in a unstable medical condition or has alcohol/drug abuse in recent 6months

• Patient whose female partner is less interested in sexual intercourse or has a sexualdisorder

• Patient whose female partner is pregnant

• Patient whose female partner of childbearing age is not willing to use proper birthcontrol

• Patient whose IIEF-EF score is 25 and less

• Medical history of convulsive diseases, mental diseases, E.C.T (Electroconvulsiveshock Treatment), glaucoma

• Patient who has taken concomitantly prohibited medicines before the study and who isnot willing to stop the medications for appropriate wash-out period