Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Colon Cancer

Last updated: April 17, 2021
Sponsor: Konkuk University Medical Center
Overall Status: Completed

Phase

N/A

Condition

Colon Cancer

Colorectal Cancer

Treatment

N/A

Clinical Study ID

NCT02567942
KUH1160089
  • Ages > 20
  • All Genders

Study Summary

Anesthetics agents has variety inflammation during the cancer surgery. This perioperative inflammation can influence to cancer metastasis or recurrence.

The purpose of this study is to prove the variation of immune cell activity between preoperative and postoperative period.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patient who was planned to undergo colon cancer surgery.

Exclusion

Exclusion Criteria:

  • age < 20 years old
  • history of hypersensitivity reaction in propofol or sevoflurane
  • history of previous cancer
  • patient with ongoing inflammation

Study Design

Total Participants: 153
Study Start date:
February 01, 2016
Estimated Completion Date:
April 30, 2018

Study Description

The patients were allocated randomly to receive propofol or sevoflurane. Also, a total of 18ml of blood sample was obtained for total 3 times in consecutive order.

  1. immediate before anesthesia induction

  2. postoperative 1 hours

  3. postoperative 24 hours

Serum in blood will be obtained and activity of helper T cell, natural killer cell and level of serum cytokine will be evaluated by flow cytometry or enzyme-linked immunosorbent assay

Connect with a study center

  • Konkuk University Medical Center

    Seoul, 143-729
    Korea, Republic of

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.