Double-masked Study of Netarsudil (AR-13324) Ophthalmic Solution in Subjects With Glaucoma or Ocular Hypertension

Inclusion Criteria:

1. 18 years of age or older

2. Diagnosis of open angle glaucoma or ocular hypertension in both eyes

3. Post-washout intraocular pressure >20mmHg and <30mmHg in 1 or both eyes at 2qualification visits

4. Corrected visual acuity equivalent to 20/200

5. Able to give informed consent and follow study instructions

Exclusion Criteria:

1. Clinically significant ocular disease

2. Pseudoexfoliation or pigment dispersion component glaucoma, history of angle closureor narrow angles

3. Unmedicated intraocular pressure ≥30mmHg

4. Use of more than 2 ocular hypotensive medications within 30 days of screening

5. Known hypersensitivity to any component of the formulation

6. Previous glaucoma surgery or refractive surgery

7. Ocular trauma within 6 months prior to screening

8. Any ocular surgery or non-refractive laser treatment within 3 months prior toscreening

9. Recent or current ocular infection or inflammation in either eye

10. Used ocular medication in either eye of any kind within 30 days of screening

11. Mean central corneal thickness >620µm at screening

12. Any abnormality preventing reliable applanation tonometry of either eye

13. Clinically significant abnormalities in lab tests at screening

14. Known hypersensitivity or contraindication to beta-adrenoceptor antagonists

15. Clinically significant systemic disease

16. Participation in any investigational study within 60 days prior to screening

17. Used any systemic medication that could have a substantial effect in intraocularpressure within 30 days prior to screening

18. Women who are pregnant, nursing, planning a pregnancy or not using a medicallyacceptable form of birth control