TREg Activation in the Treatment of the PELADE (Alopecia Areata)

Inclusion Criteria:

• Of more than 18 years old,

• Affiliated to the social security system,

• Clinical diagnosis of alopecia areata,

• 50 % of the surface of the scalp affected

• Last flaire started less than one year

• Alopecia areata resisting to at least 1 systematic treatment including phototherapy (UVB or PUVA), general corticosteroid therapy or methotrexate

• Signature of the informed consent

Exclusion Criteria:

• Pregnancy or refusal of contraception at the women old enough to procreate,

• Refusal of contraception at the men

• Local treatment (dermocorticoïdes, minoxidil) or systematism (oral corticosteroidtherapy, méthotrexate or the other immunosuppresseur) since less than 2 less,

• Evolutionary autoimmune cancer or disease or in forgiveness

• Excessive grip(taking) of alcohol (upper to 3 glasses of wine a day or one pre-lunchdrink a day)

• Seropositivity VHC, VHB, or HIV

• Patient presenting a severe renal and/or hepatic insufficiency,

• Presenting patient one zoned, the chicken pox, the herpes, the tuberculosis, anevolutionary infectious disease, a respiratory failure …

• Vulnerable person (nobody under guardianship minor(miner), adults, deprived offreedom)

• IC in the treatment(processing) by IL-2R

• Presenting a contraindication to ProleukinR