Randomized Global Phase 3 Study to Evaluate the Impact on NASH With Fibrosis of Obeticholic Acid Treatment

Last updated: September 5, 2024
Sponsor: Intercept Pharmaceuticals
Overall Status: Terminated

Phase

3

Condition

Liver Disease

Treatment

Placebo

Obeticholic Acid

Clinical Study ID

NCT02548351
747-303
  • Ages 18-85
  • All Genders

Study Summary

The primary objectives of this study are to evaluate the effect of Obeticholic Acid treatment compared to placebo on 1) histological improvement and 2) liver-related clinical outcomes in patients with non-cirrhotic nonalcoholic steatohepatitis (NASH) with liver fibrosis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Histologic evidence of NASH upon central read of a liver biopsy obtained no morethan 6 months before Day 1 defined by presence of all 3 key histological features ofNASH according to NASH CRN criteria.

  2. Histologic evidence of fibrosis stage 2 or stage 3 as defined by the NASH CRNscoring of fibrosis, or Histologic evidence of fibrosis stage 1a or stage 1b if accompanied by ≥1 of thefollowing risk factors:

  • Obesity (BMI ≥30 kg/m2)

  • Type 2 diabetes diagnosed per 2013 American Diabetes Association criteria

  • ALT >1.5× upper limit of normal (ULN).

  1. For subjects with a historical biopsy, is either not taking or is on stable doses ofTZDs/glitazones or vitamin E for 6 months before Day 1.

  2. Stable body weight.

Exclusion

Exclusion Criteria:

  1. Model for End-stage Liver Disease (MELD) score >12

  2. ALT ≥10× ULN

  3. HbA1c >9.5%

  4. Total bilirubin >1.5 mg/dL

  5. Evidence of other known forms of known chronic liver disease such as alcoholic liverdisease, hepatitis B, hepatitis C, PBC, PSC, autoimmune hepatitis, Wilson disease,iron overload, alpha-1-antitrypsin deficiency, drug-induced liver injury, known orsuspected hepatocellular carcinoma (HCC)

  6. History of liver transplant, or current placement on a liver transplant list

  7. Current or history of significant alcohol consumption

  8. Prior or planned ileal resection, or prior or planned bariatric surgery

  9. Histological presence of cirrhosis

  10. History of biliary diversion

  11. Known positivity for human immunodeficiency virus infection.

  12. Acute cholecystitis or acute biliary obstruction.

  13. BMI >45 kg/m2

Study Design

Total Participants: 2477
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 3
Study Start date:
September 22, 2015
Estimated Completion Date:
September 15, 2023

Connect with a study center

  • Concord Repatriation General Hospital

    Concord, New South Wales 2139
    Australia

    Site Not Available

  • Royal Adelaide Hospital Gastroenterology and Hepatology Dept.

    Adelaide, 5000
    Australia

    Site Not Available

  • Flinders Medical Centre

    Bedford Park, 5042
    Australia

    Site Not Available

  • Royal Brisbane and Women's Hospital

    Brisbane, 4029
    Australia

    Site Not Available

  • AW Morrow Gastroenterology and Liver Centre Royal Prince Alfred Hospital

    Camperdown, 2050
    Australia

    Site Not Available

  • Monash Health - Monash Medical Centre

    Clayton, 3168
    Australia

    Site Not Available

  • Gallipoli Medical Research Foundation

    Greenslopes, 4120
    Australia

    Site Not Available

  • Austin Hospital

    Heidelberg, 3084
    Australia

    Site Not Available

  • Royal Brisbane and Women's Hospital

    Herston, 4029
    Australia

    Site Not Available

  • Nepean Hospital

    Kingswood, 2747
    Australia

    Site Not Available

  • The Alfred Hospital, Department of Gastroenterology

    Melbourne, 3004
    Australia

    Site Not Available

  • Fiona Stanley Hospital

    Murdoch, 6150
    Australia

    Site Not Available

  • The Royal Melbourne Hospital

    Parkville, 3053
    Australia

    Site Not Available

  • The Alfred Hospital

    Prahan, 3181
    Australia

    Site Not Available

  • The Alfred Hospital

    Prahran, 3181
    Australia

    Site Not Available

  • Westmead Hospital

    Westmead, 2145
    Australia

    Site Not Available

  • Universitätsklinik für Innere Medizin I Innsbruck

    Innsbruck, 6020
    Austria

    Site Not Available

  • Klinikum Klagenfurt am Wörthersee

    Klagenfurt, 9020
    Austria

    Site Not Available

  • Ordensklinikum Linz GmbH

    Linz, 4010
    Austria

    Site Not Available

  • Uniklinikum Salzburg

    Salzburg, 5020
    Austria

    Site Not Available

  • Medizinische Universität Wien

    Wien, 1090
    Austria

    Site Not Available

  • UZ Antwerpen

    Edegem, Antwerpen 2650
    Belgium

    Site Not Available

  • ULB Hȏpital Erasme - Gastroenterology

    Brussels, Brabant 1070
    Belgium

    Site Not Available

  • UZ Leuven Campus Gathuisberg Hepatology Department

    Leuven, Vlaams-Brabant 3000
    Belgium

    Site Not Available

  • AZ Sint-Jan Brugge Oostende

    Brugge, B-8000
    Belgium

    Site Not Available

  • UCL Saint-Luc - Hepatology Department

    Brussels, 1200
    Belgium

    Site Not Available

  • Ziekenhuis Oost-Limburg (ZOL)

    Genk, 3600
    Belgium

    Site Not Available

  • UZ Gent Gastroenterology Department

    Ghent, 9000
    Belgium

    Site Not Available

  • AZ Nikolaas

    Sint-Niklaas, 9100
    Belgium

    Site Not Available

  • London Health Sciences Centre University Hospital

    London, Ontario N6A 5A5
    Canada

    Site Not Available

  • University of Alberta

    Alberta, T6G 2X8
    Canada

    Site Not Available

  • University of Calgary Liver Unit

    Calgary, T2N 4Z6
    Canada

    Site Not Available

  • GI Research

    Edmonton, T5H 4B9
    Canada

    Site Not Available

  • University of Alberta

    Edmonton, T6G 2X8
    Canada

    Site Not Available

  • Centre de Recherche du Centre Hospitalier de l'Universite de Montreal

    Montreal, H2X 0A9
    Canada

    Site Not Available

  • The Research Institute of the McGill University Health Centre

    Montreal, H4A 3J1
    Canada

    Site Not Available

  • Toronto Center for Liver Disease

    Toronto, M5G 2C4
    Canada

    Site Not Available

  • Toronto Liver Centre

    Toronto, M6H 3M1
    Canada

    Site Not Available

  • GIRI - GI Research Institute

    Vancouver, V6Z 2K5
    Canada

    Site Not Available

  • Gordon and Leslie Diamond Health Care Centre

    Vancouver, V5Z 1M9
    Canada

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  • LAIR Centre

    Vancouver, V5Z 1H3
    Canada

    Site Not Available

  • PerCuro Clinical Research Ltd.

    Victoria, V8V 3M9
    Canada

    Site Not Available

  • John Buhler Research Centre

    Winnipeg, R3E 3P4
    Canada

    Site Not Available

  • Aalborg University Hospital

    Aalborg, 9001
    Denmark

    Site Not Available

  • Aarhus University Hospital Medicinsk Hepatogastroenterologisk Afdeling

    Aarhus, 8200
    Denmark

    Site Not Available

  • Aarhus Universitetshospital

    Aarhus C, 8000
    Denmark

    Site Not Available

  • Copenhagen University Hospital Hvidovre

    Hvidovre, 2650
    Denmark

    Site Not Available

  • Odense University Hospital

    Odense, 5000
    Denmark

    Site Not Available

  • Helsinki University Hospital

    Helsinki, 00290
    Finland

    Site Not Available

  • Turku University Hospital

    Turku, 20520
    Finland

    Site Not Available

  • CHU Amiens Picardie

    Amiens, 80054
    France

    Site Not Available

  • CHU Angers-Service d'Hepato-Gastroenterologie

    Angers, 49933
    France

    Site Not Available

  • Centre hospitalier Pierre Oudot

    Bourgoin-Jallieu, 38300
    France

    Site Not Available

  • CHU Caen, Hôpital Côte de Nacre

    Caen, 14033
    France

    Site Not Available

  • CHU Beaujon-Service d'Hépatologie

    Clichy, 92110
    France

    Site Not Available

  • Hôpital Henri Mondor - Service d'hépatologie

    Creteil, 94000
    France

    Site Not Available

  • CHU Grenoble

    Grenoble, 38700
    France

    Site Not Available

  • CHRU Hôpital Claude Huriez

    Lille, 59037
    France

    Site Not Available

  • Hôpital de la Croix Rousse

    Lyon, 69004
    France

    Site Not Available

  • Hôpital Saint Joseph

    Marseille, 13008
    France

    Site Not Available

  • Hôpital de l'Archet II-CHU Nice

    Nice, 6202
    France

    Site Not Available

  • Service d'Hepato-Gastroenterologie CHR Orleans - La Source

    Orléans, 45100
    France

    Site Not Available

  • Hospital Saint Antoine Department of Hepatology

    Paris, 75012
    France

    Site Not Available

  • Hôpital Cochin

    Paris, 75014
    France

    Site Not Available

  • Hôpital de la Pitié Salpétrère

    Paris, 75013
    France

    Site Not Available

  • Hopital Haut-Lévêque-Hépatogastroentérologie-Bât USN

    Pessac, 33604
    France

    Site Not Available

  • CHU de Rouen

    Rouen, 76031
    France

    Site Not Available

  • CHU Toulouse - Hopital de Purpan

    Toulouse, 31059
    France

    Site Not Available

  • CHU de Nancy - Hôpital de Brabois adultes

    Vandoeuvre-Lès-Nancy, 54500
    France

    Site Not Available

  • Hopital Paul Brousse

    Villejuif, 94804
    France

    Site Not Available

  • Universitätsklinikum Heidelberg Medizinischen Klinik IV Gastroenterologie und Hepatologie

    Heidelberg, Baden-Wurttemberg 69120
    Germany

    Site Not Available

  • Universitatsklinikum Mannheim

    Mannheim, Baden-Wurttemberg 68167
    Germany

    Site Not Available

  • Friedrich-Alexander-Universität Erlangen Medizinische Klinik 1

    Erlangen, Bavaria 91054
    Germany

    Site Not Available

  • Klinikum der Johann-Wolfgang Goethe Universitat

    Frankfurt, Hesse 60590
    Germany

    Site Not Available

  • Klinikum der Johann-Wolfgang Goethe Universitat

    Frankfurt/Main, Hesse 60596
    Germany

    Site Not Available

  • Universitätsmedizin Mainz, I. Med. Klinik und Poliklinik

    Mainz, Rhineland-Palatinate 55131
    Germany

    Site Not Available

  • Universitätsklinikum Leipzig Klinik für Gastroenterologie und Rheumatologie-Sektion Hepatologie

    Leipzig, Saxony 04103
    Germany

    Site Not Available

  • Universitatsklinikum Aachen, RWTH Aachen, Medizinische Klinik III

    Aachen, 52074
    Germany

    Site Not Available

  • Charite Universitätsmedizin Campus Virchow

    Berlin, 13353
    Germany

    Site Not Available

  • St. Josef-Hospital, Ruhr University Bochum

    Bochum, 44791
    Germany

    Site Not Available

  • Universitätskliniken Bonn AöR

    Bonn, 53127
    Germany

    Site Not Available

  • University Hosptial Cologne Clinics for Gastroenterology and Hepatology

    Cologne, 50937
    Germany

    Site Not Available

  • University of Düsseldorf

    Düsseldorf, 40225
    Germany

    Site Not Available

  • Katholische Kliniken Ruhrhalbinsel GmbH

    Essen, 45257
    Germany

    Site Not Available

  • University Hospital Essen

    Essen, 45147
    Germany

    Site Not Available

  • Ifi- Studien und Projekte GmbH

    Hamburg, 20099
    Germany

    Site Not Available

  • Universitätsklinikum Hamburg- Eppendorf

    Hamburg, 20246
    Germany

    Site Not Available

  • Medizinische Hochschule Hannover

    Hannover, 30625
    Germany

    Site Not Available

  • Gastroenterologische Gemeinschaftspraxis

    Herne, 44623
    Germany

    Site Not Available

  • Universitätsklinikum des Saarlandes

    Homburg, 66421
    Germany

    Site Not Available

  • Hepato-Gastroenterology Center Kiel

    Kiel, 24146
    Germany

    Site Not Available

  • Universitätsklinik Köln

    Köln, 50931
    Germany

    Site Not Available

  • EUGASTRO GmbH

    Leipzig, 04103
    Germany

    Site Not Available

  • Krankenhaus Barmherzige Bruder Innere Medizin I - Gastroenterologie

    Munich, 80639
    Germany

    Site Not Available

  • Universitätsklinikum Würzburg

    Würzburg, 97080
    Germany

    Site Not Available

  • Egyesitett Szent Istvan és Szent Laszlo

    Budapest, 1097
    Hungary

    Site Not Available

  • Pecsi Tudomanyegyetem Klinikai Kozpont, I. sz

    Budapest, 7624
    Hungary

    Site Not Available

  • Kenezy Gyula Korhaz es Rendelointezet

    Debrecen, 4031
    Hungary

    Site Not Available

  • Pecsi Tudomanyegyetem Klinikai Kozpont, I. sz

    Pécs, 7624
    Hungary

    Site Not Available

  • Soroka Medical Center Division of Internal Medicine

    Be'er Sheva, 84101
    Israel

    Site Not Available

  • Carmel Medical Center

    Haifa, 34362
    Israel

    Site Not Available

  • Rambam Medical Center Center for Liver diseases

    Haifa, 3109601
    Israel

    Site Not Available

  • Hadassah Ein Kerem MC

    Jerusalem, 91120
    Israel

    Site Not Available

  • Shaarei Zedek Medical Center

    Jerusalem, 03235
    Israel

    Site Not Available

  • West Galilee Hospital

    Nahariya, 22100
    Israel

    Site Not Available

  • Holy Family Medical Center

    Nazareth, 16100
    Israel

    Site Not Available

  • Rabin Medical Center, Liver Institute

    Petach Tikva, 4941492
    Israel

    Site Not Available

  • Sheba Medical Center

    Ramat Gan, 52621
    Israel

    Site Not Available

  • Sourasky Tel-Aviv Medical Center

    Tel Aviv, 64239
    Israel

    Site Not Available

  • Universita di Bologna - DIMEC

    Bologna, 40138
    Italy

    Site Not Available

  • University di Bologna - Dipartimento di Scienze Mediche e Chirurgiche - DIMEC

    Bologna, 40138
    Italy

    Site Not Available

  • Università degli Studi di Firenze

    Firenze, 20139
    Italy

    Site Not Available

  • Ospedale san Giuseppe - Multimedica

    Milan, 20123
    Italy

    Site Not Available

  • Azienda Socio-Sanitaria Territoriale (ASST) Santi Paolo e Carlo

    Milano, 20142
    Italy

    Site Not Available

  • Fondazione IRCCS Ca Granda Ospedale

    Milano, 20122
    Italy

    Site Not Available

  • Fondazione IRCCS Ca Grande Ospedale

    Milano,
    Italy

    Site Not Available

  • AOU di Modena Ospedale Civile

    Modena, 41126
    Italy

    Site Not Available

  • Azienda Ospedaliero Universitaria Policlinico

    Naples, 80131
    Italy

    Site Not Available

  • Azienda Ospedaliera Universitaria Policlinico

    Napoli, 80131
    Italy

    Site Not Available

  • University of Padova

    Padova, 35128
    Italy

    Site Not Available

  • Policlinico Paolo Giaccone di Palermo

    Palermo, 90127
    Italy

    Site Not Available

  • University of Tor Vergata (Roma)

    Roma, 00133
    Italy

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  • Policlinico University Campus Biomedico

    Rome, 00128
    Italy

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  • Istituto Clinico Humanitas

    Rozzano, 20089
    Italy

    Site Not Available

  • A.O.U. Città della Salute e della Scienza di Torino

    Torino, 10126
    Italy

    Site Not Available

  • University of Amsterdam

    Amsterdam, 1100DD
    Netherlands

    Site Not Available

  • Radboud University Nijmegen Medical Center

    Nijmegen, 6526 GA
    Netherlands

    Site Not Available

  • University Medical Center Utrecht

    Utrecht, 3584 CX
    Netherlands

    Site Not Available

  • NZ Liver Transplant Unit

    Grafton, Auckland 1023
    New Zealand

    Site Not Available

  • Middlemore Hospital

    Auckland, 2025
    New Zealand

    Site Not Available

  • Dunedin Hospital

    Dunedin, 9016
    New Zealand

    Site Not Available

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Bialystok, 15-540
    Poland

    Site Not Available

  • Centrum Badan Klinicznych PI-House Sp. z o.o.

    Gdansk, 80-546
    Poland

    Site Not Available

  • Uniwersyteckie Centrum Kliniczne im. Prof K. Gibinskiego Slaskiego Uniwersytetu Medycznego w Katowicach

    Katowice, 40-752
    Poland

    Site Not Available

  • Wojewodzki Specjalistyczny Szpital im. Dr WI. Bieganskiego

    Lodz, 91-347
    Poland

    Site Not Available

  • Samodzielny Publiczny Szpital Kliniczny Nr 1

    Lublin, 20-081
    Poland

    Site Not Available

  • Centrum Badan Klinicznych Piotr Napora

    Wroclaw, 51-349
    Poland

    Site Not Available

  • Centro Hospitalar do Baixo Vouga, E.P.E.

    Aveiro, 3814-201
    Portugal

    Site Not Available

  • Ulsba, Epe

    Beja, 7801-849
    Portugal

    Site Not Available

  • Centro Hosipitalar e Universitário de Coimbra

    Coimbra, 3000-075
    Portugal

    Site Not Available

  • Hospital de Santo Antonio

    Douro, 4099-001
    Portugal

    Site Not Available

  • Hospital da Senhora da Oliveira - Guimarães

    Guimarães, 4835-044
    Portugal

    Site Not Available

  • CHLC, EPE - Hospital de Santo Antonio dos Capuchos

    Lisboa, 1169-050
    Portugal

    Site Not Available

  • Centro Hospitalar de Lisboa Norte, EPE - Hosp. de Santa Maria

    Lisboa, 1649-035
    Portugal

    Site Not Available

  • Centro Hospitalar Lisboa Ocidental

    Lisbon, 1349-019
    Portugal

    Site Not Available

  • Centro Hospitalar Trás-os-Montes e Alto Douro, EPE

    Lordelo, 5000-508
    Portugal

    Site Not Available

  • Centro Hospitalar São João, EPE -Hospital de São João

    Porto, 4200-319
    Portugal

    Site Not Available

  • Centro Hospitalar do Tras-os-Montes e Alto Douro, EPE

    Villa Real, 5000-508
    Portugal

    Site Not Available

  • University of Puerto Rico

    Ponce, 00716
    Puerto Rico

    Site Not Available

  • Ave Ponce De Leon #715

    San Juan, 00918
    Puerto Rico

    Site Not Available

  • Fundacion de Investigacion

    San Juan, 00927
    Puerto Rico

    Site Not Available

  • Klinical Investigations Group, LLC

    San Juan, 00909
    Puerto Rico

    Site Not Available

  • Clinical Center of Serbia

    Belgrade, 11000
    Serbia

    Site Not Available

  • Clinical Hospital Center Bezanijska Kosa

    Belgrade, 11080
    Serbia

    Site Not Available

  • University Medical Centar Zvezdara

    Belgrade, 11000
    Serbia

    Site Not Available

  • Kliničko Bolnički Centar Zvezdara

    Beograd, 11000
    Serbia

    Site Not Available

  • Clinical Center Nis

    Nis, 18000
    Serbia

    Site Not Available

  • Hospital Universitari Son Espases

    Palma de Mallorca, Baleares 07120
    Spain

    Site Not Available

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, Madrid 28222
    Spain

    Site Not Available

  • Hospital Universitario Fundación Alcorcon

    Alcorcon, 28291
    Spain

    Site Not Available

  • Hospital Universitario Fundación Alcorcon

    Alcorcón, 28922
    Spain

    Site Not Available

  • Hospital General y Universitario de Alicante

    Alicante, 03010
    Spain

    Site Not Available

  • Hospital Clinic(o) de Barcelona

    Barcelona, 08036
    Spain

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  • Hospital Universitario Vall d'Hebron

    Barcelona, 08035
    Spain

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  • Hospital del Mar Gastroenterology Department

    Barcelona, 08003
    Spain

    Site Not Available

  • Complejo Asistencial Universitario de Leon

    Leon, 24071
    Spain

    Site Not Available

  • Hospital Universitario La Paz

    Madrid, 28046
    Spain

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  • Hospital Universitario Ramón y Cajal

    Madrid, 28034
    Spain

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  • Hospital (Universitario) Virgen de la Victoria

    Malaga, 29010
    Spain

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  • Clinica Universidad de Navarra

    Pamplona,
    Spain

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  • Hospital Universitario Donostia

    San Sebastian, 20014
    Spain

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  • Hospital (Universitario) Marqués de Valdecilla

    Santander, 39008
    Spain

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  • Hospital Clinico Universitario de Santiago

    Santiago de Compostela, 15706
    Spain

    Site Not Available

  • Hospital Universitario Virgen del Rocio

    Sevilla, 41013
    Spain

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  • Consorcio Hospital General Universitario

    Valencia, 46014
    Spain

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  • Hospital Clinico Universitario de Valencia

    Valencia, 46010
    Spain

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  • Hospital Universitario La Fe.

    Valencia, 46026
    Spain

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  • Hospital Clinico Universitario Zaragoza

    Zaragoza, 50009
    Spain

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  • Hospital Universitario Miguel Servet

    Zaragoza, 50009
    Spain

    Site Not Available

  • Sahlgrenska University Hospital

    Gothenburg, SE-413 45
    Sweden

    Site Not Available

  • Universitetsjukhuset Linkoping

    Linkoping, SE-581 85
    Sweden

    Site Not Available

  • Karolinska University Hospital

    Stockholm, SE-141 86
    Sweden

    Site Not Available

  • UVCM Hepatologie

    Bern, 3010
    Switzerland

    Site Not Available

  • Centre Hospitalier Universitaire Vaudois

    Lausanne,
    Switzerland

    Site Not Available

  • Epatocentro Ticino

    Lugano, 6900
    Switzerland

    Site Not Available

  • Hospital of St. Gallen

    St.Gallen, 9007
    Switzerland

    Site Not Available

  • University Clinic of Gastroenterology & Hepatology

    Zürich, 8091
    Switzerland

    Site Not Available

  • Royal Cornwall Hospital

    Truro, Cornwall TR1 3LJ
    United Kingdom

    Site Not Available

  • Royal Devon & Exeter Hospital

    Exeter, Devon EX2 5DW
    United Kingdom

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  • Royal Bournemouth Hospital

    Bournemouth, Dorset BH7 7DW
    United Kingdom

    Site Not Available

  • Queen Alexandra Hospital

    Portsmouth, Hampshire PO6 3LY
    United Kingdom

    Site Not Available

  • Norfolk and Norwich University Hospitals

    Norwich, Norfolk NR4 7UY
    United Kingdom

    Site Not Available

  • John Radcliffe Hospital

    Headington, Oxford OX3 9DU
    United Kingdom

    Site Not Available

  • Oxford University Hospital NHS Trust

    Headington, Oxford OX3 9DU
    United Kingdom

    Site Not Available

  • Royal Surrey NHS Foundation Trust

    Guildford, Surrey GU27XX
    United Kingdom

    Site Not Available

  • Institute of Biomedical Research

    Birmingham, B15 2TT
    United Kingdom

    Site Not Available

  • Bradford Royal Infirmary

    Bradford, BD9 6RJ
    United Kingdom

    Site Not Available

  • Royal Alexander Children's Hospital (CIRU)

    Brighton,
    United Kingdom

    Site Not Available

  • University Hospital Bristol NHS Foundation Trust

    Bristol, BS2 8HW
    United Kingdom

    Site Not Available

  • Cambridge University Hospital

    Cambridge, CB2 0QQ
    United Kingdom

    Site Not Available

  • University Hospitals Coventry & Warwickshire

    Coventry, CV2 2DX
    United Kingdom

    Site Not Available

  • Glasgow Royal Infirmary, NHS Greater

    Glasgow, G4 0SF
    United Kingdom

    Site Not Available

  • Gastroenterology Department Hull Royal Infirmary

    Hull, HU3 2JZ
    United Kingdom

    Site Not Available

  • University Hospital Aintree

    Liverpool, L9 7AL
    United Kingdom

    Site Not Available

  • Guy's and St. Thomas NHS Foundation Trust

    London, SE1 9RT
    United Kingdom

    Site Not Available

  • Institute for Liver and Digestive Health

    London, NW3 2QG
    United Kingdom

    Site Not Available

  • Royal London Hospital

    London, E1 1FR
    United Kingdom

    Site Not Available

  • St. Mary's Hospital

    London, W2 1NY
    United Kingdom

    Site Not Available

  • Central Manchester University Hospital NHS Foundation Trust Manchester Royal Infirmary

    Manchester, M13 9WL
    United Kingdom

    Site Not Available

  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust

    Newcastle Upon Tyne, NE7 7DN
    United Kingdom

    Site Not Available

  • Nottingham Digestive Diseases and Biomedical Research Unit

    Nottingham, NG7 2UH
    United Kingdom

    Site Not Available

  • Derriford Hospital

    Plymouth, PL6 8DH
    United Kingdom

    Site Not Available

  • The University of Alabama at Birmingham

    Birmingham, Alabama 35294
    United States

    Site Not Available

  • Digestive Health Specialists of the Southeast

    Dothan, Alabama 36305
    United States

    Site Not Available

  • University of South Alabama

    Mobile, Alabama 36688
    United States

    Site Not Available

  • Institute for Liver Health DBA Arizona Liver Health

    Chandler, Arizona 85224
    United States

    Site Not Available

  • Arizona Liver Health - Glendale

    Glendale, Arizona 85306
    United States

    Site Not Available

  • Banner Advanced Liver Disease and Transplant Institute

    Phoenix, Arizona 85006
    United States

    Site Not Available

  • Mayo Clinic Arizona

    Phoenix, Arizona 85054
    United States

    Site Not Available

  • St. Joseph's Hospital and Medical Center

    Phoenix, Arizona 85013
    United States

    Site Not Available

  • Arizona Liver Clinic - Tucson

    Tucson, Arizona 85711
    United States

    Site Not Available

  • Liver Wellness Center

    Little Rock, Arkansas 72205
    United States

    Site Not Available

  • Arkansas Gastroenterology

    North Little Rock, Arkansas 72117
    United States

    Site Not Available

  • GW Research Inc.

    Chula Vista, California 91910
    United States

    Site Not Available

  • Precision Research Institute

    Chula Vista, California 91910
    United States

    Site Not Available

  • Southern California Research Center

    Coronado, California 92118
    United States

    Site Not Available

  • Citrus Valley Gastroenterology

    Covina, California 91722
    United States

    Site Not Available

  • TriWest Research Associates, LLC

    El Cajon, California 92020
    United States

    Site Not Available

  • Fresno Clinical Research Center

    Fresno, California 93720
    United States

    Site Not Available

  • UCSF Fresno, Clinical Research Center

    Fresno, California 93701
    United States

    Site Not Available

  • Citrus Valley Gastroenterology

    Glendora, California 91740
    United States

    Site Not Available

  • Scripps Clinic

    La Jolla, California 92037
    United States

    Site Not Available

  • University of California, San Diego

    La Jolla, California 92037
    United States

    Site Not Available

  • VA Loma Linda Healthcare System

    Loma Linda, California 92357
    United States

    Site Not Available

  • Cedars-Sinai Medical Center

    Los Angeles, California 90048
    United States

    Site Not Available

  • Gastrointestinal Biosciences

    Los Angeles, California 90067
    United States

    Site Not Available

  • Keck Medical Center of USC

    Los Angeles, California 90033
    United States

    Site Not Available

  • National Research Institute, Wilshire

    Los Angeles, California 90057
    United States

    Site Not Available

  • Veteran Affairs Great Los Angeles Healthcare System

    Los Angeles, California 90073
    United States

    Site Not Available

  • Surinder Saini, M.D., Inc

    Newport Beach, California 92660
    United States

    Site Not Available

  • Stanford University

    Palo Alto, California 94304
    United States

    Site Not Available

  • Inland Empire Liver Foundation

    Rialto, California 92377
    United States

    Site Not Available

  • University of California Davis Medical Center

    Sacramento, California 95817
    United States

    Site Not Available

  • Kaiser Permanente

    San Diego, California 92154
    United States

    Site Not Available

  • Medical Associates Research Group

    San Diego, California 92123
    United States

    Site Not Available

  • eStudy Site

    San Diego, California 92120
    United States

    Site Not Available

  • California Pacific Medical Center (CPMC)

    San Francisco, California 94109
    United States

    Site Not Available

  • Quest Clinical Research

    San Francisco, California 94115
    United States

    Site Not Available

  • UCSF/ San Francisco General Hospital

    San Francisco, California 94110
    United States

    Site Not Available

  • University of California, San Francisco

    San Francisco, California 94143
    United States

    Site Not Available

  • Silicon Valley Research Institute

    San Jose, California 95128
    United States

    Site Not Available

  • Silicon Valley Research Institute, San Jose Gastroenterology

    San Jose, California 95128
    United States

    Site Not Available

  • University of Colorado Denver and Hospital

    Aurora, Colorado 80045
    United States

    Site Not Available

  • South Denver Gastroenterology, PC

    Englewood, Colorado 80113
    United States

    Site Not Available

  • Western States Clinical Research, Inc.

    Wheat Ridge, Colorado 80033
    United States

    Site Not Available

  • Bridgeport Hospital

    Bridgeport, Connecticut 06610
    United States

    Site Not Available

  • Medical Research Center of Connecticut, LLC

    Hamden, Connecticut 06518
    United States

    Site Not Available

  • Yale University School of Medicine

    New Haven, Connecticut 06520
    United States

    Site Not Available

  • Georgetown University Hospital

    Washington, District of Columbia 20007
    United States

    Site Not Available

  • Georgetown University Hospital

    Washington, D.C., District of Columbia 20007
    United States

    Site Not Available

  • Integrity Clinical Research, LLC

    Doral, Florida 33166
    United States

    Site Not Available

  • UF Hepatology Research at CTRB

    Gainesville, Florida 32610
    United States

    Site Not Available

  • Nature Coast Clinical Research

    Inverness, Florida 34452
    United States

    Site Not Available

  • Mayo Clinic

    Jacksonville, Florida 32224
    United States

    Site Not Available

  • UF Health Jacksonville-Gastroenterology Emerson

    Jacksonville, Florida 32207
    United States

    Site Not Available

  • Florida Digestive Health Specialist Research Institute

    Lakewood Ranch, Florida 34211
    United States

    Site Not Available

  • Sunrise Medical Research, Inc.

    Lauderdale Lakes, Florida 33319
    United States

    Site Not Available

  • Meridien Research

    Maitland, Florida 32751
    United States

    Site Not Available

  • Bruce W. Carter Miami VA Medical Center

    Miami, Florida 33125
    United States

    Site Not Available

  • Janus Clinical Research, Inc.

    Miami, Florida 33186
    United States

    Site Not Available

  • ProLive Medical Research

    Miami, Florida 33175
    United States

    Site Not Available

  • Schiff Center for Liver Diseases

    Miami, Florida 33136
    United States

    Site Not Available

  • Sensible Healthcare, LLC

    Ocoee, Florida 34761
    United States

    Site Not Available

  • Florida Hospital Transplant Institute

    Orlando, Florida 32804
    United States

    Site Not Available

  • South Florida Center of Gastroenterology, P.A.

    Wellington, Florida 33414
    United States

    Site Not Available

  • Cleveland Clinic Florida

    Weston, Florida 33331
    United States

    Site Not Available

  • Florida Medical Clinic, P.A.

    Zephyrhills, Florida 33542
    United States

    Site Not Available

  • Summit Clinical Research, LLC

    Athens, Georgia 30607
    United States

    Site Not Available

  • Digestive Healthcare of Georgia

    Atlanta, Georgia 30309
    United States

    Site Not Available

  • Piedmont Atlanta Hospital

    Atlanta, Georgia 30309
    United States

    Site Not Available

  • The Emory Clinic (TEC)

    Atlanta, Georgia 30322
    United States

    Site Not Available

  • Georgia Regents University

    Augusta, Georgia 30912
    United States

    Site Not Available

  • Gastrointestinal Specialists of Georgia

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Gastrointestinal Specialists of Georgia, PC

    Marietta, Georgia 30060
    United States

    Site Not Available

  • Georgia Clinical Research, LLC

    Snellville, Georgia 30078
    United States

    Site Not Available

  • The Queen's Medical Center - Liver Center

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Grand Teton Research Group

    Idaho Falls, Idaho 83404
    United States

    Site Not Available

  • Northwestern University, Feinberg School of Medicine

    Chicago, Illinois 60611
    United States

    Site Not Available

  • The University of Chicago Medical Center

    Chicago, Illinois 60637
    United States

    Site Not Available

  • Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • Indiana University Health University Hospital

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Indianapolis Gastroenterology & Hepatology

    Indianapolis, Indiana 46237
    United States

    Site Not Available

  • Indiana University (IU) Health University Hospital

    Indiannapolis, Indiana 46202
    United States

    Site Not Available

  • The University of Kansas Medical Center

    Kansas City, Kansas 66160
    United States

    Site Not Available

  • The Medical Center of Bowling Green

    Bowling Green, Kentucky 42101
    United States

    Site Not Available

  • Gastroenterology Associates of Hazard

    Hazard, Kentucky 41701
    United States

    Site Not Available

  • University of Kentucky Chandler Medical Center

    Lexington, Kentucky 40536
    United States

    Site Not Available

  • University of Louisville Medical, Clinical Trials Unit

    Louisville, Kentucky 40202
    United States

    Site Not Available

  • Ochsner Clinic Foundation

    New Orleans, Louisiana 70121
    United States

    Site Not Available

  • Tulane Medical Center

    New Orleans, Louisiana 70112
    United States

    Site Not Available

  • Louisiana Research Center, LLC

    Shreveport, Louisiana 71105
    United States

    Site Not Available

  • Investigative Clinical Research

    Annapolis, Maryland 21401
    United States

    Site Not Available

  • Johns Hopkins Hospital

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • Mercy Medical Center

    Baltimore, Maryland 21202
    United States

    Site Not Available

  • Walter Reed National Military Medical Center

    Bethesda, Maryland 20889
    United States

    Site Not Available

  • Digestive Disease Associates, PA

    Catonsville, Maryland 21228
    United States

    Site Not Available

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Boston Medical Center

    Boston, Massachusetts 02118
    United States

    Site Not Available

  • Massachusetts General Hospital

    Boston, Massachusetts 02114
    United States

    Site Not Available

  • Commonwealth Clinical Studies

    Brockton, Massachusetts 02302
    United States

    Site Not Available

  • Lahey Hospital & Medical Center

    Burlington, Massachusetts 01805
    United States

    Site Not Available

  • University of Massachusetts Medical School

    Worcester, Massachusetts 01655
    United States

    Site Not Available

  • Henry Ford Health System

    Detroit, Michigan 48202
    United States

    Site Not Available

  • Gastroenterology Associates of Western Michigan, d.b.a West Michigan Clinical Research

    Wyoming, Michigan 49519
    United States

    Site Not Available

  • Huron Gastroenterology Associates/Center for Digestive Care

    Ypsilanti, Michigan 48197
    United States

    Site Not Available

  • Minnesota Gastroenterology

    Minneapolis, Minnesota 55413
    United States

    Site Not Available

  • Mayo Clinic

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Minnesota Gastroenterology

    Saint Paul, Minnesota 55413
    United States

    Site Not Available

  • Minnesota Gastroenterology, P.A.

    St. Paul, Minnesota 55114
    United States

    Site Not Available

  • Southern Therapy and Advanced Research, LLC

    Jackson, Mississippi 39216
    United States

    Site Not Available

  • Kansas City Research Institute

    Kansas City, Missouri 64131
    United States

    Site Not Available

  • Kansas City VA Medical Center

    Kansas City, Missouri 64128
    United States

    Site Not Available

  • Saint Louis University Gastroenterology & Hepatology

    Saint Louis, Missouri 63104
    United States

    Site Not Available

  • Washington University School of Medicine - Gastroenterology

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Washington University School of Medicine

    St. Louis, Missouri 63110
    United States

    Site Not Available

  • CHI Health Alegent Creighton Clinic Gastroenterology

    Omaha, Nebraska 68124
    United States

    Site Not Available

  • AGA Clinical Research Associates, LLC

    Egg Harbor City, New Jersey 08234
    United States

    Site Not Available

  • AGA Clinical Research Associates, LLC

    Egg Harbor Township, New Jersey 08234
    United States

    Site Not Available

  • Amici Clinical Research

    Martinsville, New Jersey 08836
    United States

    Site Not Available

  • Amici GI - LLC

    Martinsville, New Jersey 08836
    United States

    Site Not Available

  • Rutgers University New Jersey Medical School

    Newark, New Jersey 07103
    United States

    Site Not Available

  • Saint Joseph's Regional Medical Center

    Paterson, New Jersey 07503
    United States

    Site Not Available

  • The Gastroenterology Group of South Jersey

    Vineland, New Jersey 08360
    United States

    Site Not Available

  • AccumetRx Clinical research / UGNM

    Albuquerque, New Mexico 87109
    United States

    Site Not Available

  • Montefiore Medical Center

    Bronx, New York 10467
    United States

    Site Not Available

  • University at Buffalo, Clinical and Translational Research Center

    Buffalo, New York 14203
    United States

    Site Not Available

  • North Shore University Hospital

    Manhasset, New York 11030
    United States

    Site Not Available

  • Columbia University Medical Center

    New York, New York 10032
    United States

    Site Not Available

  • Concorde Medical Group PLLC

    New York, New York 10016
    United States

    Site Not Available

  • Icahn School of Medicine at Mt. Sinai

    New York, New York 10029
    United States

    Site Not Available

  • Mount Sinai Beth Israel

    New York, New York 10003
    United States

    Site Not Available

  • New York University (NYU) Langone Medical Center

    New York, New York 10016
    United States

    Site Not Available

  • Weill Cornell Medical College

    New York, New York 10021
    United States

    Site Not Available

  • Premier Medical Group of the Hudson Valley, PC

    Poughkeepsie, New York 12601
    United States

    Site Not Available

  • University of Rochester Medical Center

    Rochester, New York 14642
    United States

    Site Not Available

  • Montefiore Medical Center

    The Bronx, New York 10467
    United States

    Site Not Available

  • Asheville Gastroenterology Associates, PA

    Asheville, North Carolina 28801
    United States

    Site Not Available

  • University of North Carolina at Chapel Hill, School of Medicine

    Chapel Hill, North Carolina 27599-7584
    United States

    Site Not Available

  • Center for Liver Disease

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • Charlotte Gastroenterology & Hepatology

    Charlotte, North Carolina 28207
    United States

    Site Not Available

  • Duke University Medical Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Cumberland Research Associates, LLC

    Fayetteville, North Carolina 28304
    United States

    Site Not Available

  • Carolinas Center for Liver Disease/Carolinas HeatlhCare System

    Huntersville, North Carolina 28078
    United States

    Site Not Available

  • Wake Research Associates, LLC

    Raleigh, North Carolina 27612
    United States

    Site Not Available

  • Piedmont Healthcare, Carolinas Center for Liver Disease

    Statesville, North Carolina 28677
    United States

    Site Not Available

  • Digestive Health Specialists, PA

    Winston-Salem, North Carolina 27103
    United States

    Site Not Available

  • Consultants for Clinical Research

    Cincinnati, Ohio 45249
    United States

    Site Not Available

  • University of Cincinnati

    Cincinnati, Ohio 45267-0595
    United States

    Site Not Available

  • MetroHealth Medical Center

    Cleveland, Ohio 44109
    United States

    Site Not Available

  • University Hospitals Case Medical Center

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio 43203
    United States

    Site Not Available

  • Center for Digestive Health

    Mentor, Ohio 44059
    United States

    Site Not Available

  • Clinical Research Solutions

    Middleburg Heights, Ohio 44130
    United States

    Site Not Available

  • INTEGRIS Baptist Medical Center

    Oklahoma City, Oklahoma 73112
    United States

    Site Not Available

  • Oregon Health & Science University (OHSU)

    Portland, Oregon 97239
    United States

    Site Not Available

  • Doylestown Health Gastroenterology

    Doylestown, Pennsylvania 18901
    United States

    Site Not Available

  • Hillmont GI, pc

    Flourtown, Pennsylvania 19031
    United States

    Site Not Available

  • The Pennsylvania State University and The Milton S. Hershey Medical Center

    Hershey, Pennsylvania 17033
    United States

    Site Not Available

  • Hillmont G.I. - Lansdale Office

    Lansdale, Pennsylvania 19446
    United States

    Site Not Available

  • Main Line Gastroenterology Associates

    Perkasie, Pennsylvania 18944
    United States

    Site Not Available

  • Drexel University

    Philadelphia, Pennsylvania 19102
    United States

    Site Not Available

  • Einstein Healthcare Network

    Philadelphia, Pennsylvania 19141
    United States

    Site Not Available

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Thomas Jefferson University

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • UPMC

    Pittsburgh, Pennsylvania 15213
    United States

    Site Not Available

  • University Gastroenterology

    Providence, Rhode Island 02905
    United States

    Site Not Available

  • University Gastroenterology, Liver Center

    Providence, Rhode Island 02905
    United States

    Site Not Available

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Site Not Available

  • Prisma Health- Upstate Gastroenterology and Liver Center

    Greenville, South Carolina 29605
    United States

    Site Not Available

  • Rapid City Medical Center

    Rapid City, South Dakota 57701
    United States

    Site Not Available

  • WR-Clinsearch, LLC

    Chattanooga, Tennessee 37421
    United States

    Site Not Available

  • Gastro One

    Germantown, Tennessee 38138
    United States

    Site Not Available

  • Associates in Gastroenterology, PLC

    Hermitage, Tennessee 37076
    United States

    Site Not Available

  • Clinical Research Solutions

    Jackson, Tennessee 38305
    United States

    Site Not Available

  • East Tennesse Research Institute

    Johnson City, Tennessee 37604
    United States

    Site Not Available

  • Methodist Healthcare, University Hospital

    Memphis, Tennessee 38104
    United States

    Site Not Available

  • Nashville Gastrointestinal Specialists

    Nashville, Tennessee 37205
    United States

    Site Not Available

  • Quality Medical Research, PLLC

    Nashville, Tennessee 37211
    United States

    Site Not Available

  • Vanderbilt University Medical Center

    Nashville, Tennessee 37232
    United States

    Site Not Available

  • Texas Clinical Research Institute

    Arlington, Texas 76012
    United States

    Site Not Available

  • Austin Center for Clinical Research

    Austin, Texas 78756
    United States

    Site Not Available

  • Liver Center of Texas

    Dallas, Texas 75234
    United States

    Site Not Available

  • Texas Digestive Disease Consultants

    Dallas, Texas 75246
    United States

    Site Not Available

  • The Liver Institute at Methodist Dallas Medical Center

    Dallas, Texas 75203
    United States

    Site Not Available

  • UT Southwestern Medical Center

    Dallas, Texas 75390
    United States

    Site Not Available

  • MedResearch, Inc.

    El Paso, Texas 79935
    United States

    Site Not Available

  • Brooke Army Medical Center

    Fort Sam Houston, Texas 78234
    United States

    Site Not Available

  • Baylor Scott & White All Saints Medical Center

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Texas Digestive Disease Consultants

    Fort Worth, Texas 76104
    United States

    Site Not Available

  • Brooke Army Medical Center (Geneva Foundation)

    Ft. Sam Houston, Texas 78234
    United States

    Site Not Available

  • Baylor College of Medicine

    Houston, Texas 77030
    United States

    Site Not Available

  • Baylor College of Medicine Ben Taub General Hospital

    Houston, Texas 77030
    United States

    Site Not Available

  • Centex Studies, Inc.

    Houston, Texas 77058
    United States

    Site Not Available

  • Houston Methodist Hospital

    Houston, Texas 77030
    United States

    Site Not Available

  • Liver Associates of Texas, P.A.

    Houston, Texas 77030
    United States

    Site Not Available

  • The University of Texas Health Science Center at Houston-Medical School IM-Division of Gastroenterology, Hepatology & Nutrition

    Houston, Texas 77030
    United States

    Site Not Available

  • Gastroenterology Consultants of San Antonio

    Live Oak, Texas 78233
    United States

    Site Not Available

  • Centex Studies, Inc.

    McAllen, Texas 78504
    United States

    Site Not Available

  • American Research Corporation at the Texas Liver Institute

    San Antonio, Texas 78215
    United States

    Site Not Available

  • Gastroenterology Consultants of San Antonio

    San Antonio, Texas 78229
    United States

    Site Not Available

  • Texas Digestive Disease Consultants - San Marcos

    San Marcos, Texas 78666
    United States

    Site Not Available

  • Intermountain Medical Center

    Murray, Utah 84107
    United States

    Site Not Available

  • University of Utah Hospital

    Salt Lake City, Utah 84132
    United States

    Site Not Available

  • The University of Vermont Medical Center - Smith 2

    Burlington, Vermont 05401
    United States

    Site Not Available

  • University of Virginia Health System

    Charlottesville, Virginia 22908
    United States

    Site Not Available

  • Inova Fairfax Medical Campus

    Falls Church, Virginia 22042
    United States

    Site Not Available

  • Digestive and Liver Disease Specialists

    Norfolk, Virginia 23502
    United States

    Site Not Available

  • Bon Secours St. Mary's Hospital

    Richmond, Virginia 23226
    United States

    Site Not Available

  • McGuire DVAMC GI

    Richmond, Virginia 23249
    United States

    Site Not Available

  • Virginia Commonwealth University Clinical Research Services Unit (CRSU)

    Richmond, Virginia 23298
    United States

    Site Not Available

  • Liver Institute Northwest

    Seattle, Washington 98105
    United States

    Site Not Available

  • Swedish Organ Transplant and Liver Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • University of Washington Medical Center

    Seattle, Washington 98195
    United States

    Site Not Available

  • Virginia Mason - Seattle Medical Center

    Seattle, Washington 98101
    United States

    Site Not Available

  • University of Wisconsin Hospital & Clinics

    Madison, Wisconsin 53705
    United States

    Site Not Available

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