Tong-Xie-Yao-Fang Granules for Diarrhea-predominant Irritable Bowel Syndrome

Inclusion Criteria:

• Being diagnosed as IBS according to the Rome III criteria;

• Diarrhea was present for at least 75% of the time;

• With a TCM differentiation as "liver stagnation and spleen defficiency"

• Had a colonoscopy within a year to rule out other bowel diseases.

Exclusion Criteria:

• Organic gastrointestinal disease, such as colorectal cancer, inflammatory boweldisease, advanced colonic polyp;

• Had gastrointestinal surgery within a year;

• Used durgs that affect gastrointestinal motility;

• Had psychological disorder;

• Serious disease in other system, which may bias the outcome measures.