A Study Of PF-06410293 (Adalimumab-Pfizer) And Adalimumab (Humira®) In Combination With Methotrexate In Subjects With Active Rheumatoid Arthritis (REFLECTIONS B538-02).

Inclusion Criteria:

• Diagnosis of rheumatoid arthritis based on 2010 ACR/EULAR criteria for at least 4months.

• At least 6 tender (of 68 assessed) and 6 swollen (of 66 assessed) joints at screeningand baseline.

• Hs-CRP equal or greater than 8 mg/L.

• Must have received methotrexate for at least 12 weeks and been on a stable dose for atleast 4 weeks prior to the first study dose.

Exclusion Criteria:

• Evidence of untreated or inadequately treated latent or active TB.

• Evidence of uncontrolled, clinically significant diseases, including moderate orsevere heart failure (NYHA Class III/IV) or malignancy in the previous 5 years.

• History of infection requiring hospitalization or parenteral antimicrobial therapywithin 6 months prior to first dose of study drug.

• May have received no more than 2 doses of one biologic therapy (other than adalimumabor lymphocyte depleting therapy).

• Any second DMARD must be washed out prior to the first study dose.