Niacin Skin Flush Response in Patients With Schizophrenia

Last updated: May 30, 2015
Sponsor: Isfahan University of Medical Sciences
Overall Status: Completed

Phase

2/3

Condition

Tourette's Syndrome

Mood Disorders

Psychosis

Treatment

N/A

Clinical Study ID

NCT02458924
393230
  • Ages 18-65
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Patients with schizophrenia have abnormal skin flush response to niacin, but the niacin skin test accuracy is not well studied in these patients. The study evaluated the niacin skin test accuracy in adult hospitalized schizophrenia patients and their first degree relatives, bipolar disorder patients, and healthy controls.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of schizophrenia patients and bipolar disorder patients diagnosed accordingto the Diagnostic and Statistical Manual of Mental Disorders version IV criteria

  • Normal healthy subjects without a psychiatric history

  • First degree relatives of schizophrenic patients

Exclusion

Exclusion Criteria:

  • Dermatological lesions, asthma or allergic disease, diabetes, chronic hypertension,vasculitis, substance use disorders (except cigarette smoking), or pregnancy

  • Taking any oral medication that could affect the metabolism of prostaglandins such asnonsteroidal anti-inflammatory drugs or corticosteroids

Study Design

Total Participants: 100
Study Start date:
January 01, 2014
Estimated Completion Date:
September 30, 2014