Neuronal Effects of Exercise in Schizophrenia

Last updated: April 21, 2025
Sponsor: University of Colorado, Denver
Overall Status: Active - Recruiting

Phase

N/A

Condition

Tourette's Syndrome

Schizotypal Personality Disorder (Spd)

Psychosis

Treatment

Exercise

Diet

Clinical Study ID

NCT02455193
14-1282
UL1TR001082
R01MH102224
  • Ages 21-70
  • All Genders

Study Summary

This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of schizophrenia or schizoaffective disorder

  • Between 21 and 70 years of age

  • Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, ORnot currently being treated with any neuroleptic medications

  • Weight stable within 5 percent for the last 6 months

Exclusion

Exclusion Criteria:

  • Pregnancy

  • Substance abuse

  • Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severehypertriglyceridemia)

  • MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)

Study Design

Total Participants: 140
Treatment Group(s): 2
Primary Treatment: Exercise
Phase:
Study Start date:
August 01, 2014
Estimated Completion Date:
September 30, 2025

Connect with a study center

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado 80045
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.