A Study of Atezolizumab Versus Observation as Adjuvant Therapy in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (UC) After Surgical Resection

Last updated: May 22, 2023
Sponsor: Hoffmann-La Roche
Overall Status: Terminated

Phase

3

Condition

Carcinoma

Treatment

Atezolizumab

Clinical Study ID

NCT02450331
WO29636
2014-005603-25
  • Ages > 18
  • All Genders

Study Summary

This Phase III, open-label, randomized, multicenter study is to evaluate the efficacy and safety of adjuvant treatment with atezolizumab compared with observation in participants with muscle-invasive UC who are at high risk for recurrence following resection. Eligible participants were randomized by a 1:1 ratio into atezolizumab group or control group.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Histologically confirmed muscle-invasive UC (also termed transitional cell carcinoma)of the bladder or upper urinary tract (i.e., renal pelvis or ureters)
  • For participants treated with prior neoadjuvant chemotherapy: tumor stage of ypT2-4aor ypN+ (ypT2-4 or ypN+ for participants with upper urinary tract UC) and M0
  • For participants who have not received prior neoadjuvant chemotherapy: tumor stage ofpT3-4a or pN+ (pT3-4 or pN+ for participants with upper urinary tract UC) and M0
  • Representative formalin-fixed paraffin-embedded tumor specimens from surgicalresection (i.e., radical cystectomy, nephroureterectomy, or lymph node dissection) inparaffin blocks (blocks preferred) or at least 15 unstained slides, with an associatedpathology report, for central testing and determined to be evaluable for tumorprogrammed death-ligand 1 (PD-L1) expression prior to study enrollment
  • Absence of residual disease and absence of metastasis, as confirmed by a negativebaseline computed tomography (CT) or magnetic resonance imaging scan of the pelvis,abdomen, and chest no more than 4 weeks prior to randomization
  • Full recovery from cystectomy or nephroureterectomy within 14 weeks following surgery
  • Eastern Cooperative Oncology Group performance status of less than or equal to (</=) 2
  • Life expectancy greater than or equal to (>/=) 12 weeks
  • Adequate hematologic and end-organ function
  • For women who are not postmenopausal or surgically sterile: agreement to remainabstinent or use contraceptive methods that result in a failure rate of less than (<) 1 percent (%) per year during the treatment period and for at least 5 months after thelast dose of atezolizumab

Exclusion

Exclusion Criteria:

  • Any approved anti-cancer therapy within 3 weeks prior to initiation of study treatment
  • Adjuvant chemotherapy or radiation therapy for UC following surgical resection
  • Treatment with any other investigational agent or participation in another clinicaltrial with therapeutic intent within 28 days or five half-lives of the drug prior toenrollment
  • Malignancies other than UC within 5 years prior to Cycle 1, Day 1
  • Pregnancy or breastfeeding
  • Significant cardiovascular disease
  • Severe infections within 4 weeks prior to Cycle 1, Day 1
  • Major surgical procedure other than for diagnosis within 28 days prior to Cycle 1, Day 1
  • History of severe allergic, anaphylactic, or other hypersensitivity reactions tochimeric or humanized antibodies or fusion proteins
  • Known hypersensitivity to biopharmaceuticals produced in Chinese hamster ovary cellsor any component of the atezolizumab formulation
  • History of autoimmune disease
  • Prior allogeneic stem cell or solid organ transplant
  • History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-inducedpneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screeningchest CT scan
  • Positive test for human immunodeficiency virus and/or active hepatitis B or hepatitisC or tuberculosis
  • Administration of a live, attenuated vaccine within 4 weeks before Cycle 1 Day 1
  • Prior treatment with cluster of differentiation 137 (CD137) agonists or immunecheckpoint blockade therapies, including anti-CD40, anti-cytotoxicT-lymphocyte-associated protein 4 (anti-CTLA-4), anti-programmed death-1 (anti-PD-1),and anti-PD-L1 therapeutic antibodies

Study Design

Total Participants: 809
Treatment Group(s): 1
Primary Treatment: Atezolizumab
Phase: 3
Study Start date:
October 05, 2015
Estimated Completion Date:
June 14, 2022

Connect with a study center

  • Macquarie University Hospital

    Macquarie Park, New South Wales 2109
    Australia

    Site Not Available

  • Macquarie University Hospital

    Macquarie University, New South Wales 2109
    Australia

    Site Not Available

  • Macquarie University Hospital

    Sydney, New South Wales 2109
    Australia

    Site Not Available

  • Royal Brisbane & Women's Hosp; Cancer Care Serv

    Herston, Queensland 4029
    Australia

    Site Not Available

  • Monash Medical Centre; Oncology

    Clayton, Victoria 3168
    Australia

    Site Not Available

  • Monash Medical Centre; Oncology

    East Bentleigh, Victoria VIC 3165
    Australia

    Site Not Available

  • Austin and Repatriation Medical Centre; Cancer Services

    Melbourne, Victoria 3084
    Australia

    Site Not Available

  • Healthcare Institution "Gomel Regional Clinical Oncologic Dispensary"

    Gomel, 246012
    Belarus

    Site Not Available

  • Minsk City Clinical Oncologic Dispensary

    Minsk, BU-220013
    Belarus

    Site Not Available

  • N.N. Alexandrov National Cancer Centre of Belarus

    Minsk District, 223040
    Belarus

    Site Not Available

  • Vitebsk Regional Clinical Oncology Dispensary

    Vitebsk, BU-210603
    Belarus

    Site Not Available

  • Institut Jules Bordet

    Anderlecht, 1070
    Belgium

    Site Not Available

  • ZNA Middelheim

    Antwerpen, 2020
    Belgium

    Site Not Available

  • empty

    Brussels, 1200
    Belgium

    Site Not Available

  • Cliniques Universitaires St-Luc

    Bruxelles, 1200
    Belgium

    Site Not Available

  • UZ Gent

    Gent, 9000
    Belgium

    Site Not Available

  • UZ Leuven Gasthuisberg

    Leuven, 3000
    Belgium

    Site Not Available

  • Sint Augustinus Wilrijk

    Wilrijk, 2610
    Belgium

    Site Not Available

  • Cross Cancer Institute ; Dept of Medical Oncology

    Edmonton, Alberta T6G 1Z2
    Canada

    Site Not Available

  • BCCA-Vancouver Cancer Centre

    Vancouver, British Columbia V5Z 4E6
    Canada

    Site Not Available

  • Queen Elizabeth II Health Sciences Centre; Oncology

    Halifax, Nova Scotia B3H 2Y9
    Canada

    Site Not Available

  • Royal Victoria Hospital

    Barrie, Ontario L4M 6M2
    Canada

    Site Not Available

  • London Regional Cancer Centre

    London, Ontario N6A 4L6
    Canada

    Site Not Available

  • Lakeridge Health Oshawa; Oncology

    Oshawa, Ontario L1G 2B9
    Canada

    Site Not Available

  • The Ottawa Hospital Cancer Centre; Oncology

    Ottawa, Ontario K1H 8L6
    Canada

    Site Not Available

  • North York General Hospital

    Toronto, Ontario M2J 1V1
    Canada

    Site Not Available

  • Sunnybrook Odette Cancer Centre

    Toronto, Ontario M4N 3M5
    Canada

    Site Not Available

  • McGill University; Glen Site; Oncology

    Montreal, Quebec H4A 3J1
    Canada

    Site Not Available

  • CHU de Quebec Hotel-Dieu de Quebec

    Quebec City, Quebec G1R 2J6
    Canada

    Site Not Available

  • Centre Hospitalier universitaire de Québec/ Hotel Dieu de Québec

    Quebec, G1R 3S1
    Canada

    Site Not Available

  • Beijing Cancer Hospital

    Beijing, 100142
    China

    Site Not Available

  • Friendship Hospital, Capital Medical University

    Beijing, 100050
    China

    Site Not Available

  • Peking University First Hospital

    Beijing City, 100034
    China

    Site Not Available

  • the First Hospital of Jilin University

    Changchun, 130021
    China

    Site Not Available

  • Hu Nan Provincial Cancer Hospital

    Changsha, 410006
    China

    Site Not Available

  • Sun Yet-sen University Cancer Center

    Guangzhou, 510060
    China

    Site Not Available

  • The Second Affiliated Hospital, Sun Yat-sen University

    Guangzhou City, 510120
    China

    Site Not Available

  • Jiangsu Province Hospital

    Nanjing, 210008
    China

    Site Not Available

  • Jiangsu Cancer Hospital

    Nanjing City, 211100
    China

    Site Not Available

  • Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

    Shanghai, 200092
    China

    Site Not Available

  • Zhongshan Hospital Fudan University

    Shanghai, 200032
    China

    Site Not Available

  • Fudan University Shanghai Cancer Center

    Shanghai City, 200120
    China

    Site Not Available

  • Huashan Hospital Affiliated to Fudan University

    Shanghai City, 200040
    China

    Site Not Available

  • The 2nd Hospital of Tianjin Medical University

    Tianjin, 201203
    China

    Site Not Available

  • Tianjin Cancer Hospital; urologic tumor

    Tianjin City, 300060
    China

    Site Not Available

  • Masarykuv onkologicky ustav

    Brno, 656 53
    Czechia

    Site Not Available

  • Fakultni nemocnice Olomouc; Onkologicka klinika

    Olomouc, 779 00
    Czechia

    Site Not Available

  • Multiscan s.r.o.

    Pardubice, 532 03
    Czechia

    Site Not Available

  • University Hospital Motol; Department of Urology

    Praha 5, 15006
    Czechia

    Site Not Available

  • Helsinki University Central Hospital; Urology Clinics

    Helsinki, 00029
    Finland

    Site Not Available

  • Tampere University Hospital; Dept Of Urology

    Tampere, 33520
    Finland

    Site Not Available

  • Turku University Central Hospital; Urology clinic

    Turku, 20520
    Finland

    Site Not Available

  • ICO Paul Papin; Oncologie Medicale.

    Angers, 49055
    France

    Site Not Available

  • Institut Sainte Catherine;Recherche Clinique

    Avignon, 84918
    France

    Site Not Available

  • Hopital Saint Andre

    Bordeaux, 33075
    France

    Site Not Available

  • Centre Francois Baclesse; Recherche Clinique

    Caen, 14076
    France

    Site Not Available

  • Centre Jean Perrin

    Clermont Ferrand, 63011
    France

    Site Not Available

  • Centre Leon Berard; Departement Oncologie Medicale

    Lyon, 69373
    France

    Site Not Available

  • Centre D'Oncologie de Gentilly; Oncology

    Nancy, 54100
    France

    Site Not Available

  • Centre Antoine Lacassagne

    Nice, 06189
    France

    Site Not Available

  • Hopital Cochin; Unite Fonctionnelle D Oncologie

    Paris, 75014
    France

    Site Not Available

  • Hopital Europeen Georges Pompidou; Service D'Oncologie Medicale

    Paris, 75908
    France

    Site Not Available

  • Hopital Saint Louis; Oncologie Medicale

    Paris, 75475
    France

    Site Not Available

  • Institut Mutualiste Montsouris; Oncologie

    Paris, 75674
    France

    Site Not Available

  • ICO - Site René Gauducheau

    Saint Herblain, 44805
    France

    Site Not Available

  • Institut Claudius Regaud; Departement Oncologie Medicale

    Toulouse, 31059
    France

    Site Not Available

  • Institut Gustave Roussy; Departement Oncologie Medicale

    Villejuif, 94805
    France

    Site Not Available

  • Uniklinik RWTH Aachen; Klinik für Urologie

    Aachen, 52074
    Germany

    Site Not Available

  • Campus Charitè Mitte Charité Centrum 10. Klinik f.Urologie

    Berlin, 10117
    Germany

    Site Not Available

  • Augusta-Kranken-Anstalt gGmbH; Klinik für Hämatologie, Onkologie & Palliativmedizin

    Bochum, 44791
    Germany

    Site Not Available

  • Universitätsklinikum "Carl Gustav Carus"; Klinik und Poliklinik für Urologie

    Dresden, 01307
    Germany

    Site Not Available

  • Universitätsklinikum Düsseldorf; Urologische Klinik

    Düsseldorf, 40225
    Germany

    Site Not Available

  • Uniklinik Essen; Urologische Klinik & Poliklinik

    Essen, 45122
    Germany

    Site Not Available

  • Asklepios Klinik Altona, Abteilung für Urologie

    Hamburg, 22763
    Germany

    Site Not Available

  • Universitätsklinikum der Ruhr-Universität Bochum, Marien-Hospital Herne, Urologische Klinik

    Herne, 44625
    Germany

    Site Not Available

  • Universitätsklinikum des Saarlandes; Klinik für Urologie und Kinderurologie

    Homburg/Saar, 66424
    Germany

    Site Not Available

  • Medizinische Fakultät Mannheim, Universitätsklinikum Mannheim, Klinik für Urologie

    Mannheim, 68167
    Germany

    Site Not Available

  • Klinikum rechts der Isar der TU München; Urologische Klinik und Poliklinik

    München, 81675
    Germany

    Site Not Available

  • Universitätsmedizin Rostock, Urologische Klinik und Poliklinik

    Rostock, 18057
    Germany

    Site Not Available

  • Diakonie-Klinikum Stuttgart; Urologische Klinik

    Stuttgart, 70176
    Germany

    Site Not Available

  • Universitätsklinikum Tübingen; Klinik für Urologie

    Tübingen, 72076
    Germany

    Site Not Available

  • Universitätsklinikum Ulm; Klinik für Urologie

    Ulm, 89081
    Germany

    Site Not Available

  • Alexandras General Hospital of Athens; Oncology Department

    Athens, 115 28
    Greece

    Site Not Available

  • University Hospital of Patras Medical Oncology

    Patras, 265 04
    Greece

    Site Not Available

  • Rambam Health Care Campus; Oncology - Hafia

    Hafia, 3109601
    Israel

    Site Not Available

  • Hadassah Ein Karem Hospital; Oncology Dept

    Jerusalem, 9112000
    Israel

    Site Not Available

  • Meir Medical Center; Oncology

    Kfar-Saba, 4428164
    Israel

    Site Not Available

  • Rabin Medical Center; Oncology Dept

    Petach Tikva, 49100
    Israel

    Site Not Available

  • Rabin Medical Center; Oncology Dept

    Petah Tikva, 4910000
    Israel

    Site Not Available

  • Chaim Sheba Medical Center; Oncology Dept

    Ramat Gan, 5262100
    Israel

    Site Not Available

  • Tel-Aviv Sourasky Medical Center

    Tel Aviv, 6423906
    Israel

    Site Not Available

  • Assaf Harofeh; Oncology

    Zerifin, 6093000
    Israel

    Site Not Available

  • Az. Osp. Cardarelli; Divisione Di Oncologia

    Napoli, Campania 80131
    Italy

    Site Not Available

  • ISTITUTO NAZIONALE TUMORI IRCCS FONDAZIONE G. PASCALE; Dipartimento Uro-Ginecologico

    Napoli, Campania 80131
    Italy

    Site Not Available

  • Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica

    Bologna, Emilia-Romagna 40138
    Italy

    Site Not Available

  • IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica

    Meldola, Emilia-Romagna 47014
    Italy

    Site Not Available

  • Azienda Ospedaliera San Camillo Forlanini; Oncologia Medica

    Roma, Lazio 00152
    Italy

    Site Not Available

  • Irccs Istituto Europeo Di Oncologia (IEO); Cure Mediche

    Milano, Lombardia 20141
    Italy

    Site Not Available

  • Irccs Ospedale San Raffaele;Oncologia Medica

    Milano, Lombardia 20132
    Italy

    Site Not Available

  • A.O. UNIVERSITARIA S. LUIGI GONZAGA; Oncologia Medica

    Orbassano, Piemonte 10043
    Italy

    Site Not Available

  • Azienda USL8 Arezzo-Presidio Ospedaliero 1 San Donato;U.O.C. Oncologia

    Arezzo, Toscana 52100
    Italy

    Site Not Available

  • Azienda Ospedaliera S. Maria - Terni; Oncologia

    Terni, Umbria 05100
    Italy

    Site Not Available

  • Nagoya University Hospital; Urology

    Aichi, 466-8560
    Japan

    Site Not Available

  • Hirosaki University School of Medicine & Hospital; Urology

    Aomori, 036-8563
    Japan

    Site Not Available

  • Shikoku Cancer Center

    Ehime, 791-0280
    Japan

    Site Not Available

  • Hiroshima City Hiroshima Citizens Hospital; Urology

    Hiroshima, 730-8518
    Japan

    Site Not Available

  • National Hospital Organization Hokkaido Cancer Center

    Hokkaido, 003-0804
    Japan

    Site Not Available

  • University of Tsukuba Hospital

    Ibaraki, 305-8576
    Japan

    Site Not Available

  • Iwate Medical University Hospital; Urology

    Iwate, 028-3695
    Japan

    Site Not Available

  • Kyoto University Hospital

    Kyoto, 606-8507
    Japan

    Site Not Available

  • Shikoku Cancer Center

    Matsuyama-shi, 791-0280
    Japan

    Site Not Available

  • Niigata University Medical & Dental Hospital

    Niigata, 951-8520
    Japan

    Site Not Available

  • Okayama University Hospital

    Okayama, 700-8558
    Japan

    Site Not Available

  • Kindai University Hospital; Urology

    Osaka, 589-8511
    Japan

    Site Not Available

  • Osaka University Hospital; Urology

    Osaka, 565-0871
    Japan

    Site Not Available

  • Saitama Medical University International Medical Center

    Saitama, 350-1298
    Japan

    Site Not Available

  • empty

    Shinjuku-ku, 162-8666
    Japan

    Site Not Available

  • Shizuoka Cancer Center; Urology

    Shizuoka, 411-8777
    Japan

    Site Not Available

  • Kyorin University Hospital

    Tokyo, 181-8611
    Japan

    Site Not Available

  • National Cancer Center Hospital; Urology

    Tokyo, 104-0045
    Japan

    Site Not Available

  • The Cancer Institute Hospital, JFCR; Urology

    Tokyo, 135-8550
    Japan

    Site Not Available

  • The University of Tokyo Hospital

    Tokyo, 113-8655
    Japan

    Site Not Available

  • National Cancer Center

    Goyang-si, 10408
    Korea, Republic of

    Site Not Available

  • National Cancer Center; Neurology

    Gyeonggi-do, 10408
    Korea, Republic of

    Site Not Available

  • Asan Medical Center

    Seoul, 05505
    Korea, Republic of

    Site Not Available

  • Samsung Medical Center

    Seoul, 135-710
    Korea, Republic of

    Site Not Available

  • NKI/AvL

    Amsterdam, 1066 CX
    Netherlands

    Site Not Available

  • VU MEDISCH CENTRUM; Dept. of Medical Oncology

    Amsterdam, 1081 HV
    Netherlands

    Site Not Available

  • Academ Ziekenhuis Groningen; Medical Oncology

    Groningen, 9713 GZ
    Netherlands

    Site Not Available

  • empty

    Nieuwegein, 3430 EM
    Netherlands

    Site Not Available

  • UMC Radboud Nijmegen

    Nijmegen, 6500 HB
    Netherlands

    Site Not Available

  • Erasmus Mc - Daniel Den Hoed Kliniek; Interne Oncologie

    Rotterdam, 3015AA
    Netherlands

    Site Not Available

  • St. Antonius locatie Leidsche Rijn

    Utrecht, 3543 AZ
    Netherlands

    Site Not Available

  • KO-MED Centra Kliniczne Lublin II

    Lublin, 20-362
    Poland

    Site Not Available

  • Szpital Kliniczny im. Heliodora ?wi?cickiego UM w Poznaniu; Oddzia? Chemioterapii

    Pozna?, 60-569
    Poland

    Site Not Available

  • Oddzial Chemioterapii Szpitala Klinicznego Nr 1 w Poznaniu

    Poznan, 60-569
    Poland

    Site Not Available

  • Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu; Oddział Chemioterapii

    Poznań, 60-569
    Poland

    Site Not Available

  • SpecjalistycznySzpital Miejski w Toruniu; Oddzia? Urologii Ogólnej i Onkologicznej

    Toru?, 87-100
    Poland

    Site Not Available

  • SpecjalistycznySzpital Miejski w Toruniu; Oddział Urologii Ogólnej i Onkologicznej

    Toruń, 87-100
    Poland

    Site Not Available

  • Szpital Kliniczny Dzieci?tka Jezus; Oddzia? Urologii

    Warszawa, 02-005
    Poland

    Site Not Available

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego; Oddzial Urologii i Onkologii

    Wroclaw, 50-556
    Poland

    Site Not Available

  • SBEI of HPE ?Bashkir State Medical University? of MoH RF

    UFA, Baskortostan 450000
    Russian Federation

    Site Not Available

  • P.A. Herzen Oncological Inst. ; Oncology

    Moscow, Moskovskaja Oblast 125248
    Russian Federation

    Site Not Available

  • GBUZ Nizhegorodskay Region: Clinical Diagnostic Center

    Nizhni Novgorod, Niznij Novgorod 603001
    Russian Federation

    Site Not Available

  • Privolzhsk Regional Medical Center

    Nizhny Novgorod, Niznij Novgorod 603001
    Russian Federation

    Site Not Available

  • Sverdlovsk Regional Oncology Dispensary; Chemotherapy

    Ekaterinburg, Sverdlovsk 620905
    Russian Federation

    Site Not Available

  • Ivanovo Regional Oncology Dispensary

    Ivanovo, 153040
    Russian Federation

    Site Not Available

  • City Clinical Oncology Dispensary

    Saint-Petersburg, 197022
    Russian Federation

    Site Not Available

  • MCMC Medical City; Oncology

    Tumen, 625047
    Russian Federation

    Site Not Available

  • SBEI of HPE ?Bashkir State Medical University? of MoH RF

    Ufa, 450000
    Russian Federation

    Site Not Available

  • Clinic for Urology; Clinical Hospital Center "Dragisa Misovic-Dedinje"

    Belgrade, 11000
    Serbia

    Site Not Available

  • Clinical Center of Serbia; Clinic of Urology

    Belgrade, 11000
    Serbia

    Site Not Available

  • Clinical Center of Vojvodina

    Novi Sad, 21000
    Serbia

    Site Not Available

  • Oncology Institute of Vojvodina

    Sremska Kamenica, 21204
    Serbia

    Site Not Available

  • Hospital Univ. Central de Asturias; Servicio de Oncologia

    Oviedo, Asturias 33011
    Spain

    Site Not Available

  • Corporacio Sanitaria Parc Tauli; Servicio de Oncologia

    Sabadell, Barcelona 8208
    Spain

    Site Not Available

  • Hospital Univ Vall d'Hebron; Servicio de Oncologia

    Sant Andreu de La Barca, Barcelona 08740
    Spain

    Site Not Available

  • Hospital de Donostia; Servicio de Oncologia Medica

    San Sebastian, Guipuzcoa 20080
    Spain

    Site Not Available

  • Hospital Clinic de Barcelona. Unidad de Nuevas Terapias;Oncology Department

    Barcelona, 08036
    Spain

    Site Not Available

  • Hospital Univ Vall d'Hebron; Servicio de Oncologia

    Barcelona, 08035
    Spain

    Site Not Available

  • Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia

    Barcelona, 08041
    Spain

    Site Not Available

  • Hospital Clinico San Carlos; Servicio de Oncologia

    Madrid, 28040
    Spain

    Site Not Available

  • Hospital General Universitario Gregorio Marañon; Servicio de Oncologia

    Madrid, 28007
    Spain

    Site Not Available

  • Hospital Ramon y Cajal; Servicio de Oncologia

    Madrid, 28034
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre; Servicio de Oncologia

    Madrid, 28041
    Spain

    Site Not Available

  • Hospital Universitario La Paz; Servicio de Oncologia

    Madrid, 28046
    Spain

    Site Not Available

  • Instituto Valenciano Oncologia; Oncologia Medica

    Valencia, 46009
    Spain

    Site Not Available

  • UniversitätsSpital Zürich; Zentrum für Hämatologie und Onkologie, Klinik für Onkologie

    Zürich, 8091
    Switzerland

    Site Not Available

  • Taichung Veterans General Hospital; Division of Urology

    Taichung, 407
    Taiwan

    Site Not Available

  • National Taiwan University Hospital, Department of Urology

    Taipei, 10048
    Taiwan

    Site Not Available

  • Chang Gung Medical Foundation-Linkou, Urinary Oncology

    Taoyuan, 333
    Taiwan

    Site Not Available

  • Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital; Medical Oncology

    Adana, 01230
    Turkey

    Site Not Available

  • Hacettepe Uni Medical Faculty Hospital; Oncology Dept

    Ankara, 06100
    Turkey

    Site Not Available

  • Trakya University Medical Faculty Research And Practice Hospital Medical Oncology Department

    Edirne, 22770
    Turkey

    Site Not Available

  • Istanbul Uni Cerrahpasa Medical Faculty Hospital; Medical Oncology

    Istanbul, 34300
    Turkey

    Site Not Available

  • Ege Uni Medical Faculty; Oncology Dept

    Izmir, 35100
    Turkey

    Site Not Available

  • Medikal Park Izmir Hospital

    Kar??yaka, 35575
    Turkey

    Site Not Available

  • Medikal Park Izmir Hospital

    Karşıyaka, 35575
    Turkey

    Site Not Available

  • Hacettepe Uni Medical Faculty Hospital; Oncology Dept

    Sıhhiye, ANKARA, 06100
    Turkey

    Site Not Available

  • Regional Clinical Center of Urology and Nephrology n.a. V.I. Shapoval Department of Urology #4

    Kharkiv, Kharkiv Governorate 61037
    Ukraine

    Site Not Available

  • CI Dnipropetrovsk CMCH #4 MA of MOHU Ch of Oncology and MR

    Dnipropetrovsk, 49102
    Ukraine

    Site Not Available

  • GU "Institution of urology of Academy Medical science of Ukraine"

    Kiev, 04053
    Ukraine

    Site Not Available

  • Lviv State Oncology Regional Treatment and Diagnostic Centre; Department of hemotherapy

    Lviv, 79031
    Ukraine

    Site Not Available

  • empty

    Zaporizhzhya, 69040
    Ukraine

    Site Not Available

  • Zaporozhye Regional Oncology Hospital; Dept of Oncology

    Zaporozhye, 69104
    Ukraine

    Site Not Available

  • University Hospitals Birmingham NHS Foundation Trust

    Birmingham, B15 2TH
    United Kingdom

    Site Not Available

  • University Hospitals Bristol NHS Foundation Trust

    Bristol, BS2 8HW
    United Kingdom

    Site Not Available

  • empty

    Cambridge, CB2 2QQ
    United Kingdom

    Site Not Available

  • Beatson West of Scotland Cancer Centre

    Glasgow, G12 0YN
    United Kingdom

    Site Not Available

  • Barts Health NHS Trust - St Bartholomew's Hospital

    London, EC1A 7BE
    United Kingdom

    Site Not Available

  • Sarah Cannon Research Institute

    London, W1G 6AD
    United Kingdom

    Site Not Available

  • James Cook Uni Hospital

    Middlesborough, TS4 3BW
    United Kingdom

    Site Not Available

  • Churchill Hospital

    Oxford, OX3 7LJ
    United Kingdom

    Site Not Available

  • Royal Preston Hosptial

    Preston, PR2 9HT
    United Kingdom

    Site Not Available

  • Southampton General Hospital

    Southampton, SO16 6YD
    United Kingdom

    Site Not Available

  • Mayo Clinic Arizona

    Phoenix, Arizona 85259
    United States

    Site Not Available

  • HonorHealth Research Institute - Pima - Virginia G. Piper Cancer Care Network

    Scottsdale, Arizona 85258
    United States

    Site Not Available

  • CBCC Global Research Inc., at Comprehensive Blood and Cancer Center

    Bakersfield, California 93309
    United States

    Site Not Available

  • UCLA

    Los Angeles, California 90024
    United States

    Site Not Available

  • USC Norris Cancer Center

    Los Angeles, California 90033
    United States

    Site Not Available

  • Stanford University Medical Center

    Palo Alto, California 94304
    United States

    Site Not Available

  • Torrance Heath Association DBA Torrance Memorial Physican Network / Cancer Care Associate

    Redondo Beach, California 90277
    United States

    Site Not Available

  • Pacific Central Coast Health Centers SLO Oncology and Hematology

    San Luis Obispo, California 93401
    United States

    Site Not Available

  • Stanford University Medical Center

    Stanford, California 94305
    United States

    Site Not Available

  • University Of Colorado

    Aurora, Colorado 80045
    United States

    Site Not Available

  • The Urology Center of Colorado

    Denver, Colorado 80211
    United States

    Site Not Available

  • Yale Cancer Center; Medical Oncology

    New Haven, Connecticut 06520
    United States

    Site Not Available

  • University Of Miami Hospital

    Miami, Florida 33136
    United States

    Site Not Available

  • Northwestern University Feinberg School Of Medicine

    Chicago, Illinois 60611
    United States

    Site Not Available

  • University of Chicago; Hematology/Oncology

    Chicago, Illinois 60637
    United States

    Site Not Available

  • Indiana University

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • University of Iowa Hospital & Clinic; Division of Hematology/Oncology

    Iowa City, Iowa 52242
    United States

    Site Not Available

  • Cancer Center of Kansas

    Wichita, Kansas 67214
    United States

    Site Not Available

  • Albert B. Chandler Medical Center; University of Kentucky

    Lexington, Kentucky 40536
    United States

    Site Not Available

  • Norton Cancer Institute

    Louisville, Kentucky 40202
    United States

    Site Not Available

  • New England Cancer Specialists

    Scarborough, Maine 04074
    United States

    Site Not Available

  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • Chesapeake Urology Research Associates

    Towson, Maryland 21204
    United States

    Site Not Available

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Dana Farber Cancer Inst.

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • Massachusetts General Hospital.

    Boston, Massachusetts 2114
    United States

    Site Not Available

  • University Of Michigan

    Ann Arbor, Michigan 48109
    United States

    Site Not Available

  • Henry Ford Health System

    Detroit, Michigan 48202
    United States

    Site Not Available

  • Karmanos Cancer Institute

    Detroit, Michigan 48201
    United States

    Site Not Available

  • University of Minnesota

    Minneapolis, Minnesota 55455
    United States

    Site Not Available

  • Southeast Nebraska Cancer Ctr

    Lincoln, Nebraska 68510
    United States

    Site Not Available

  • MSK @Basking Ridge

    Basking Ridge, New Jersey 07920
    United States

    Site Not Available

  • Saint Barnabas Medical Center Cancer Center

    Livingston, New Jersey 07039
    United States

    Site Not Available

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey 08901
    United States

    Site Not Available

  • Memorial Sloan-Kettering Cancer Center

    Commack, New York 11725
    United States

    Site Not Available

  • MSKCC @ West Harrison

    Harrison, New York 10604
    United States

    Site Not Available

  • Monter Cancer Center

    Lake Success, New York 11042
    United States

    Site Not Available

  • empty

    New Hyde Park, New York 11042
    United States

    Site Not Available

  • Columbia University Medical Center

    New York, New York 10032
    United States

    Site Not Available

  • Laura and ISAAC Perlmutter Cancer Center at NYU Langone.

    New York, New York 10016
    United States

    Site Not Available

  • MSKC @ Rockville

    Rockville Centre, New York 11570
    United States

    Site Not Available

  • MSKCC at Sleepy Hollow

    Sleepy Hollow, New York 10591
    United States

    Site Not Available

  • Associated Medical Professionals of NY, PLLC

    Syracuse, New York 13210-1155
    United States

    Site Not Available

  • MSKCC @ West Harrison

    West Harrison, New York 10604
    United States

    Site Not Available

  • Levine Cancer Institute

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • Duke Cancer Center

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Wake Forest University Baptist Medical Center

    Winston Salem, North Carolina 27157
    United States

    Site Not Available

  • Wake Forest University Baptist Medical Center

    Winston-Salem, North Carolina 27157
    United States

    Site Not Available

  • Cleveland Clinic

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • Fairview Hospital; Cleveland Clinic Cancer Center

    Cleveland, Ohio 44111
    United States

    Site Not Available

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio 43212
    United States

    Site Not Available

  • Hillcrest Hospital; Hirsch Cancer Center

    Mayfield Heights, Ohio 44124
    United States

    Site Not Available

  • Cleveland CL N Coast Cancer Cr

    Sandusky, Ohio 44870
    United States

    Site Not Available

  • St. Luke's University Health network

    Bethlehem, Pennsylvania 18015
    United States

    Site Not Available

  • empty

    Easton, Pennsylvania 18045
    United States

    Site Not Available

  • Penn State Milton S. Hershey Medical Center

    Hershey, Pennsylvania 17033
    United States

    Site Not Available

  • Abramson Cancer Center; Univ of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Fox Chase-Temple Cancer Center

    Philadelphia, Pennsylvania 19111
    United States

    Site Not Available

  • Kimmel Cancer Center Thomas Jefferson University

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • Miriam Hospital

    Providence, Rhode Island 02906
    United States

    Site Not Available

  • University of Texas Southwestern

    Dallas, Texas 75390-8897
    United States

    Site Not Available

  • Baylor College of Medicine; Gastroenterology

    Houston, Texas 77030
    United States

    Site Not Available

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas 78229
    United States

    Site Not Available

  • University of Virginia

    Charlottesville, Virginia 22906
    United States

    Site Not Available

  • Seattle Cancer Care Alliance

    Seattle, Washington 98109
    United States

    Site Not Available

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