Phase
Condition
Dysfunctional Uterine Bleeding
Thrombosis
White Cell Disorders
Treatment
N/AClinical Study ID
Ages 18-70 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Patients fulfilled the 1997 ACR modified or SLICC classification criteria of SLE;
- New onset thrombocytopenia: platelet count <30X109/L(by both routine test and citricacid anti-coagulated blood count test) within 3 months
Exclusion
Exclusion Criteria:
- Thrombocytopenia caused by other reasons, including drugs;
- Positive for active HAV(hepatitis A virus)/HBV(hepatitis B virus) infection
- Active HIV(human immunodeficiency virus) or HCV(hepatitis C virus) infection;
- Active HP(Helicopter pylori) infection;
- Severe liver and kidney dysfunction;
- Severe neuropsychiatric lupus;
- No response to high dose steroid and/or cyclophosphamide 1 month prior to studyenrollment;
- Uncontrolled diabetes or hypertension before entry
- Active GI bleeding 3 months before entry
- Intolerant to HCQ in the past treatment history;
- Severe bone marrow suppression or liver damage caused by cyclophosphamide in the pasthistory;
- Active infection , including bacteria, virus, fungi, mycobacteria
- Allergy to any of the study medications
- Confirmed TTP(thrombolic thrombocytopenic purpura)or CAPS(catastrophicanti-phosphilipid syndrome)
- Platelet count less than 20X109/L with active bleeding
- Myelodysplastic diseases
- Patients with heart and lung function impairment
- thiopurine S-methyltransferase (TPMT) gene positive -
Study Design
Study Description
Connect with a study center
the Affiliated Hospital to Bangbu Medical University
Bangbu, Anhui 233000
ChinaSite Not Available
Hebei Provincial Hospital
Shijiazhuang, Hebei 050051
ChinaSite Not Available
the First Affiliated Hospital of Xiangya Medical University
Changsha, Hunan 410000
ChinaSite Not Available
the Affiliated Hospital of Inner Mongolia Medical University
Huhehaote, Inner Mongolia 010050
ChinaSite Not Available
Sino-Japanese Friendship Hospital of Jilin University
Changchun, Jilin 410008
ChinaSite Not Available
Xijing Hospital
Xian, Shanxi 710032
ChinaSite Not Available
the Affiliated Hospital of Xian Communication Hospital
Xian, Shanxi 710000
ChinaSite Not Available
Xinjiang Provincial Hospital
Urumqi, Xinjiang 830001
ChinaSite Not Available
the Affiliated Hospital of Kunming Medical University
Kunming, Yunnan 650032
ChinaSite Not Available
Beijing Chaoyang Hospital
Beijing, 100020
ChinaSite Not Available
Beijing Xuanwu Hospital
Beijing, 100053
ChinaSite Not Available
Beijng Hospital
Beijing, 100006
ChinaSite Not Available
China-Japan Friendship Hospital
Beijing, 100029
ChinaSite Not Available
Peking Union Medical College Hospital
Beijing, 100032
ChinaSite Not Available
General Hospital of Tianjing Medical University
Tianjin, 300052
ChinaSite Not Available
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