A Multicenter Trial to Assess the MIcrovascular Integrity and Left Ventricular Function Recovery After Clopidogrel or TicagrelOr Administration, in Patients With STEMI Treated With Thrombolysis - The 'MIRTOS' Study

Inclusion Criteria:

1. Provision of informed consent prior to any study specific procedures.

2. Male and female subjects, 18-75 years of age (both inclusive).

3. STEMI eligible for thrombolysis

4. Inability to perform primary PCI, because of transport time in centers carrying outprimary PCI lasting more than two hours

5. Ability of transportation in 3-24 hours after thrombolysis in order to performcoronary angiography and PCI. This period may be extended for reasons of extremeimportance up to 72 hours at the latest.

Exclusion Criteria:

1. Inability to give informed consent.

2. Pre-treatment with any inhibitor of the purinergic receptor P2Y, G-protein coupled, 12 (P2Y12) within the 7-day period prior to randomization.

3. Cardiogenic shock - according to Killip classification - class 4.

4. Suspicion or evidence of mechanical complication, including mitral valve dysfunction,ventricular septal rupture, and rupture of the left ventricle.

5. Current use of warfarin or other anticoagulant drug.

6. Known multivessel coronary artery disease not suitable for revascularization.

7. Any contraindication to thrombolytic therapy -Central nervous system damage orneoplasms or atrioventricular malformation -Recent major trauma/surgery/head injury (within the preceding 3 weeks) -Gastrointestinal bleeding within the past month -Knownbleeding disorder (excluding menses) -Aortic dissection -Non-compressible punctures inthe past 24 hours (e.g. liver biopsy, lumbar puncture).

8. Other bleeding diathesis, or considered by Investigator to be at high risk forbleeding.

9. Any kind of stroke in the past year or haemorrhagic stroke ever.

10. Severe uncontrolled hypertension (>180/110 mmHg) prior to randomisation.

11. Prolonged or traumatic cardiopulmonary resuscitation (> 10 minutes) in the last 2weeks.

12. Known thrombocytopenia defined as platelet count of <100,000/mm3.

13. Known anemia (hemoglobin [Hb] <10 gr/dL).

14. Subjects receiving daily treatment with nonsteroidal anti-inflammatory drugs (NSAIDs)or cyclooxygenase-2 (COX-2) inhibitors that cannot be discontinued for the duration ofthe study.

15. Chronic dialysis or known chronic renal failure (glomerular filtration rate (GFR)<30ml/min/1.73m2).

16. Known moderate or severe hepatic impairment.

17. Severe uncontrolled chronic obstructive pulmonary disease.

18. Concomitant use of potent Cytochrome P450 3A4 (CYP3A4) inhibitors (atazanavir,clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir,ritonavir, saquinavir, telithromycin and voriconazole, grapefruit juice over 1 litredaily), CYP3A substrates with narrow therapeutic indices (cyclosporine, quinidine), orinducers (carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampin, andrifapentine).

19. Concomitant use of drugs that are metabolized through cytochrome P450, family 2,subfamily C, polypeptide 19 (CYP2C19) (omeprazole and esomeprazole, fluvoxamine,fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, ciprofloxacin,cimetidine, carbamazepine, oxcarbazepine and chloramphenicol).

20. Increased risk of bradycardic events (e.g. known sick sinus syndrome or third degreeatrioventricular (AV) block or previous documented syncope suspected to be due tobradycardia unless treated with a pacemaker).

21. Any known contraindication to clopidogrel, Acetylsalicylic Acid (ASA), or ticagrelor.

22. Current pregnancy, active lactation or parturition (childbirth) within the previous 30days; women of childbearing potential must have a negative urine pregnancy test, oruse a medically accepted method of birth control.

23. Treatment with other investigational agents (including placebo) or devices within 30days prior to randomization or planned use of investigational agents or devices priorto the completion of study participation.

24. Any non-cardiac condition with life expectancy less than 1 year.

25. Inability to adhere to the follow-up requirements or any other reason or conditionthat the investigator feels would place the patient at increased risk if theinvestigational therapy is initiated.