Impairment of Central Coherence in Restrictive Anorexia Nervosa (CoCA)

Last updated: March 28, 2018
Sponsor: Nantes University Hospital
Overall Status: Completed

Phase

N/A

Condition

Anorexia

Vomiting

Treatment

N/A

Clinical Study ID

NCT02381639
RC14_0301
  • Ages > 15
  • Female
  • Accepts Healthy Volunteers

Study Summary

The current etiological pathological model of anorexia nervosa is poly-factorial involving individual genetic and psychological factors, in close interaction with environmental, family and socio-cultural factors.

Among these factors, this study focuses on the central coherence process (cognitive ability to integrate complex information into a comprehensive meaning), in the active phase of the disease. Therefore, patients followed in the addiction service of the Nantes University Hospital will perform neuropsychological tests assessing executive functions involved in the process of central coherence.

Impairment of central coherence process could act as a maintenance factor of the disease, particularly in connection with body dysmorphic disorder. The therapeutic perspectives acting on the central coherence process like cognitive remediation deserve to deepen knowledge on the cognitive profile of patients with anorexia nervosa.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • For the patients :

  • Woman.

  • Aged of more than 15 years and 3 months.

  • Followed in the addiction service of the University Hospital of Nantes (consultations and / or hospitalizations) for Restrictive Anorexia Nervosa (according to the diagnostic criteria of DSM-IV-TR).

  • French language mastered.

  • Having signed the consent if major and if not the legal representatives havesigned the consent (for minors).

  • For the volunteers :

  • Women.

  • Aged of more than 15 years and 3 months.

  • French language mastered.

  • Having signed the consent if major and if not the legal representatives havesigned the consent (for minors).

Exclusion

Exclusion Criteria:

  • For the patients :

  • Man

  • Age under 15 years and 3 months old

  • Current Renutrition by nasogastric tube

  • Personal history of:

  • Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalancedendocrine disorder, mental retardation

  • Support for current or past cognitive remediation

  • Opposition of the patient and / or his legal representatives if minor

  • Subject under legal guardianship

  • Current participation or in the past to pharmacological research protocol (timesince the end of their participation in the protocol less than one year)

  • French language not mastered

  • For the volunteers :

  • Man

  • Age under 15 years and 3 months old

  • Current Renutrition by nasogastric tube

  • Personal history of:

  • Eating disorders

  • Head injury, neurodegenerative diseases, epilepsy unbalanced, unbalancedendocrine disorder, mental retardation

  • Support for current or past cognitive remediation

  • Opposition of the volunteer and / or his legal representatives if minor

  • Subject under legal guardianship

  • Current participation or in the past to pharmacological research protocol (timesince the end of their participation in the protocol less than one year)

  • French language not mastered

Study Design

Total Participants: 122
Study Start date:
June 11, 2015
Estimated Completion Date:
August 16, 2017

Connect with a study center

  • CHU de Nantes, Service d'Addictologie

    Nantes,
    France

    Site Not Available

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