Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD): Improving Targeting Precision

Last updated: July 9, 2024
Sponsor: Universitaire Ziekenhuizen KU Leuven
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anxiety Disorders

Obsessive-compulsive Disorder

Panic Disorders

Treatment

Standard technique

Micro-assisted technique

Clinical Study ID

NCT02377375
S57471
  • Ages 20-65
  • All Genders

Study Summary

When comparing targeting precision between DBS in parkinsonian patients and OCD patients, an unexpected deviation from the planned targets was discovered in OCD patients (Nuttin et al., 2013). The objective of this trial is to investigate whether the use of a micro-electrode assisted technique improves targeting precision in DBS at the BNST.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of OCD following the diagnostic and statistical manual of mentaldisorders-fourth edition (DSM-IV) criteria for OCD (300.3).

  • Failure of documented trials of pharmacotherapy, following an appropriate treatmentalgorithm for OCD.

  • Failure of documented trial of cognitive and behavioural therapy

  • Duration of illness: min. 5 year

  • Y-BOCS (Yale-Brown Obsessive Compulsive Scale) at least 30/40.

  • Age: 20-65 year

Exclusion

Exclusion Criteria:

  • DSM-IV diagnosis on axis 2 of severe personality disorder in cluster A or B,especially in the case of heightened risk for acting-out behavior.

  • DSM-IV diagnosis on axis 3 of organic brain pathology or significant abnormalitieson MRI.

  • Present or past history of psychotic symptoms.

  • Present substance abuse, or instable remission of substance abuses (i.e. nosubstance abuse during the last 12 months).

  • Any disorder affecting cognitive functioning, other than motor tics and Gilles de laTourette's Syndrome

  • Mental retardation. A minimum threshold of cognitive skills is needed for adequatereporting on questionnaires and evaluation, and for technical handling of theinstruments in a later faze.

Study Design

Total Participants: 10
Treatment Group(s): 2
Primary Treatment: Standard technique
Phase:
Study Start date:
January 01, 2015
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • UZ Leuven

    Leuven, Vlaams-Brabant 3000
    Belgium

    Active - Recruiting

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