5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females

Inclusion Criteria:

• Female gender, ages 18-64 years inclusive

• Current diagnosis of Major Depressive Disorder identified by the SCID-5-CT

• Current HAM-D17 score of > 15

• Adequate adherence to any FDA approved SSRI or SNRI for at least 8 weeks

Exclusion Criteria:

• Diagnosis of bipolar disorder, schizophrenia, or schizoaffective disorder, identifiedby the SCID-5-CT

• History of or current diagnosis of renal disease, such as chronic renal failure, acuterenal failure or end stage renal disease

• Diabetes type I or II

• Colitis or diverticulitis

• History of pulmonary disease

• History of fibromyalgia, lupus, eosinophilia myalgia syndrome, dermatomyositis,polymyositis, rheumatoid arthritis, psoriatic arthritis, mixed connective tissuedisease, ankylosing spondylitis, or other related rheumatological condition

• Seizure disorder

• Current serious suicide risk identified by the Columbia Severity Suicide Rating Scale

• Current treatment with an antipsychotic, mood stabilizer, or non-SSRI antidepressant

• Positive pregnancy test

• Previous diagnosis of serotonin syndrome

• Use of any excluded drugs or medications including serotonergic drugs or medications