Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata

Last updated: November 29, 2015
Sponsor: Postgraduate Institute of Medical Education and Research
Overall Status: Completed

Phase

4

Condition

Hair Loss

Alopecia

Treatment

N/A

Clinical Study ID

NCT02350023
9121/PG-2Trg/12/8073
  • Ages < 99
  • All Genders

Study Summary

Alopecia areata (AA) is an autoimmune disease that involves the hair follicles. Topical corticosteroids are the established agents for treating this disorder. There are several case reports and case series which have demonstrated the efficacy of topical prostaglandins. The two agents have not been compared head-to-head in the published literature. The investigators attempt to compare the efficacy and safety of topical betamethasone and topical latanoprost in the treatment of localised alopecia areata.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • • Cases of AA involving scalp and beard area, having 5 or less patches in all,involving less than 40% area

  • Stable disease without appearance of new patch or increase in size of existingpatch for at least 15 days

Exclusion

Exclusion Criteria:

  • • Pregnant and lactating women

  • Patients on topical treatment for alopecia in the past fifteen days or onsystemic treatment for alopecia in the past one month

  • Presence of any contraindication for topical corticosteroids (local skininfections, skin atrophy) or latanoprost (pregnancy, lactation and dermatitis)

  • Any other coexisting hair disorder (viz., trichotillomania, androgeneticalopecia, telogen effluvium)

  • Extensive disease i.e. >5 patches of AA or area involving >40% area / alopeciatotalis/ alopecia universalis/ ophiasis

Study Design

Total Participants: 50
Study Start date:
September 01, 2014
Estimated Completion Date:
March 31, 2015

Study Description

Alopecia areata (AA) is an autoimmune disease that involves the hair follicles. Topical corticosteroids are the established agents for treating this disorder. Topical prostaglandins like latanoprost have also been used for this disorder. There are several case reports and case series which have demonstrated the efficacy of topical prostaglandins. However, the two agents i.e. topical corticosteroids and topical latanoprost have not been compared head-to-head in the published literature. The investigators attempt to compare the efficacy and safety of topical betamethasone and topical latanoprost in the treatment of localised alopecia areata.

Connect with a study center

  • Dept of Dermatology, PGIMER

    Chandigarh, 160012
    India

    Site Not Available

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