The Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry

Last updated: July 8, 2024
Sponsor: Abramson Cancer Center at Penn Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Renal Cell Carcinoma

Urothelial Tract Cancer

Urologic Cancer

Treatment

N/A

Clinical Study ID

NCT02346435
17821
NA_00016036
850179
  • Ages 18-100
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Retrospective studies indicate that active surveillance for clinically localized, small renal masses (cT1a, <=4cm) is safe. It is our hypothesis that active surveillance is safe and efficacious when compared prospectively to patients undergoing immediate intervention for their small renal mass.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Must have a solid, enhancing renal mass ≤4cm at its greatest dimension found onincidental scanning in the last 6 months.

  • Age ≥ 18 and able to read, understand and sign informed consent.

  • Must be willing to adhere to the treatment algorithm and time constraints therein.

Exclusion

Exclusion Criteria:

  • Cannot have suspicion of metastases to the kidney if any other malignancy diagnosedwithin two years of study entry.

Study Design

Total Participants: 600
Study Start date:
January 01, 2009
Estimated Completion Date:
January 31, 2026

Study Description

All patients are offered active surveillance or immediate intervention, as applicable, prior to being offered consent for the DISSRM Registry. All patients are enrolled and followed prospectively. Surveillance patients are followed per protocol with serial imaging, blood work and quality of life questionnaires. Intervention patients are followed at the discretion of the attending surgeon with serial QOL appointments/questionnaires.

Connect with a study center

  • Johns Hopkins Hospital

    Baltimore, Maryland 21287
    United States

    Active - Recruiting

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