GRID Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumors

Last updated: May 11, 2026
Sponsor: Sir Mortimer B. Davis - Jewish General Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasms

Treatment

spatially fractionated radiation therapy

Clinical Study ID

NCT02333110
14-161
  • Ages > 18
  • All Genders

Study Summary

Palliative radiation therapy represents 40% of the on-going radiation at the Jewish General Hospital. In a traditional palliative radiation treatment to bulky or radioresistant tumors, radiotherapy schema varies from 24 to 30 Gys given in 3 to 10 fractions, depending on the tumor size, tumor location and tumor pathology. However, for many patients this treatment involves considerable toxicity, travel and time spent at the hospital. Spatially fractionated radiation (SFR) is an alternative technique that consists in delivering one single treatment, given through a grid containing holes. The present study is proposing to validate SFR as a safe and effective mean to palliate patients with symptomatic bulky tumors (more than 8 cm) or with tumors known to be resistant to radiation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient with histologically or cytologically confirmed malignancy. All malignanthistologies/cytologies are eligible.

  • Patient with bulky tumor (larger than 8cm), or with a tumor known to be resistant toradiation (eg. Melanoma, hypernephroma, sarcoma), or with a tumor previouslyirradiated with a palliative intent requiring more than 1 fraction of radiation

  • Patient planned to undergo palliative radiation therapy treatments to one of thefollowing 5 sites: extremities, neck, chest, abdomen and pelvis

  • WHO performance status of 0-2

  • Aged 18 years or older

  • Ability to sign and understand an informed consent form

Exclusion

Exclusion Criteria:

  • Potentially curable patient

  • Previous palliative radiation with hypofractionation

  • Tumor located near the spinal cord or in the brain

  • Pregnant or nursing woman

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: spatially fractionated radiation therapy
Phase:
Study Start date:
January 01, 2015
Estimated Completion Date:
December 31, 2027

Connect with a study center

  • Sir Mortimer Jewish General Hospital

    Montreal, Quebec H3T 1E2
    Canada

    Active - Recruiting

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