Study to Determine the Pharmacokinetics and Pharmacodynamic Effects of Phenylephrine on BP Via IV

Inclusion Criteria:

1. Subject's age is between ≥12 and 16 years, inclusive

2. Subject is scheduled for a procedure that requires general or neuraxial anesthesia

3. Subjects must have normal or clinically acceptable physical exam

4. Subjects with controlled diabetes prior to entry must have a mean systolic/diastolicoffice blood pressure ≤128/78 mmHg (sitting, after 5 minutes of rest)

5. Females must have a urine or serum pregnancy test (Human Chorionic Gonadotropin)that is negative at Screening and Day 1

6. Subject's parent or legal guardian gives informed consent and subject gives assent.

Exclusion Criteria:

1. Subject has a contraindication to vasoconstrictor therapy for control of bloodpressure

2. Subject has participated in other clinical trials for investigational drugs and/ordevices within 30 days prior to enrollment

3. Subject has any serious medical condition which, in the opinion of the investigator,is likely to interfere with study procedures

4. Subjects who have a history of any clinically significant local or systemicinfectious disease within four weeks prior to initial treatment administration

5. Subjects who are positive for hepatitis B surface antigen or hepatitis C antibody

6. Subjects taking antihypertensive medication

7. Subject is moribund (death is likely to occur in less than 48 hours)

8. Females who are pregnant, nursing or unwilling to use/practice adequatecontraception.