Why Subfertile Couples Drop Out

Last updated: March 5, 2024
Sponsor: Isala
Overall Status: Completed

Phase

N/A

Condition

Infertility

Treatment

Questionnaires

Clinical Study ID

NCT02302781
NL47393.075.14
  • Ages 18-44
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Dropout rates for fertility treatments are high. This study will examine the rate of patients that drop out during any type of subfertility work up or treatment. Furthermore, we will determine what reasons for discontinuation are and we will identify the demographic characteristics of the couples and the prognostic factors for drop out during assessment or treatment at a Fertility Centre in the Isala (Zwolle), Erasmus University Centre (Rotterdam), Elisabeth Twee Steden Hospital (Tilburg), Reinier de Graaf Group (Voorburg), St Antonius Hospital (Nieuwegein), Maxima Medical Centre (Veldhoven) and Noordwest Hospital Group (Den Helder/Alkmaar) in The Netherlands.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Couples with any type of subfertility referred to one of the four participatingcentres
  • Both partners are willing and able to separately fill out the questionnaires.

Exclusion

Exclusion Criteria:

  • Unable to read or speak the Dutch language
  • Medical contra-indication for pregnancy
  • Previous OFO (initial infertility consultation), non IVF or IVF/ICSI cycles

Study Design

Total Participants: 500
Treatment Group(s): 1
Primary Treatment: Questionnaires
Phase:
Study Start date:
April 01, 2015
Estimated Completion Date:
August 01, 2023

Study Description

Rationale Although fertility success rates are rising due to improved techniques and patients are usually highly motivated at their first visit of the clinic, dropout rates are high. Research has shown that fertility treatment is a cause for physical, psychological and economic burden.

Objective The aim of this study is to examine the rate of patient drop out during any type of subfertility work up or treatment. Furthermore, the investigators want to determine what the reasons for discontinuation are and to identify the demographic characteristics of these couples and the prognostic factors for drop out during assessment or treatment at a fertility clinic.

Study design Prospective cohort study at the fertility centres of Isala (Zwolle - The Netherlands), Erasmus University Centre (Rotterdam- The Netherlands), Elisabeth Twee Steden Hospital (Tilburg - The Netherlands), Reinier de Graaf Group (Voorburg - The Netherlands), St Antonius Hospital (Nieuwegein - The Netherlands), Maxima Medical Centre (Veldhoven - The Netherlands) and Noordwest Hospital Group (Den Helder/Alkmaar - The Netherlands).

Study population Every couple that undergoes any type of work up or treatment for subfertility problems and that has not visited any other clinic yet.

Methods Patient records of included couples will be studied and included patients will be asked to fill in a validated questionnaire after evaluations during work up or treatment. The data from both will be put in a database and analysed.

First visit (Q1) EPQ-RSS, SCREENIVF, MMQ, FertiQoL, demographic questions (128 items)

Evaluation (Q2) FertiQoL, HADS (48 items)

Evaluation (Q3) >4-6 cycles non-IVF (Q3) FertiQoL, HADS (48 items)

Evaluation (Q4) > 3 cycles IVF (Q4) FertiQoL, HADS (48 items)

Dropout (Q5) FertiQol, SCREENIVF, MMQ, PCQ-infertility, reasons for dropout (128 items)

Pregnancy (Q6) PCQ-infertility (53 items)

Connect with a study center

  • Maxima Medisch Centrum

    Veldhoven, Noord Brabant 5504 DB
    Netherlands

    Site Not Available

  • Noordwest Ziekenhuis Groep

    Den Helder, Noord Holland 1782 GZ
    Netherlands

    Site Not Available

  • Elisabeth Twee Stedeb Hospital

    Tilburg, Noord-Brabant 5022 GC
    Netherlands

    Site Not Available

  • Isala

    Zwolle, Overijssel 8000 GK
    Netherlands

    Site Not Available

  • St Antonius Hospital

    Nieuwegein, Utrecht 3435 CM
    Netherlands

    Site Not Available

  • Reinier de Graaf Ziekenhuis Groep

    Voorburg, Zuid Holland 2275 CX
    Netherlands

    Site Not Available

  • Erasmus Medical Centre

    Rotterdam, Zuid-Holland 3000 CA
    Netherlands

    Site Not Available

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