Renal Sympathetic Denervation by Iberis System in Patients With Uncontrolled Hypertension - Iberis-HTN Registry

Inclusion Criteria:

• Age ≥18 years or minimum age as required by local regulations.

• Patient has been thoroughly informed about this registry and signed Informed ConsentForm.

• Patient with true resistant hypertension defined as:

• Office systolic BP higher than 160 or 150mmHg in case of type 2 diabetes

• Ambulatory BP with average BP>130mmHg or mean daytime>135mmHg in more than 70% ofthe measurements.

• Patients should be on stable hypertension therapy for at least 8 weeks beforeprocedure, including spironolactone if they are supposed to be respondent as indicatedby the specialized center/excellence unit on hypertension.

Exclusion Criteria:

• Previous renal artery intervention (balloon angioplasty or stenting).

• Evidence of renal artery atherosclerosis (defined as a renal artery stenosis >50%).

• Main renal arteries of less than 4mm diameter or less than 20mm in length.

• Presence of multiple main renal arteries in either kidney.

• Estimated glomerular filtration rate <45ml/min per 1,73m2

• Recent myocardial infarction, unstable angina pectoris or cerebrovascular accidentwithin the past 3-6 months.

• False resistant hypertension (pseudo resistance) by using 24h ambulatory BP monitoring (ABPM).

• Secondary arterial hypertension.

• Pregnancy.

• There is another pathological process with well-known life expectancy of less than 5years.

• Patient unable to do correct FU.

• Unable to take correct ambulatory BP.

• Primary hyperaldosteronism.

• Known lack of adherence to medical treatment.